A SAURON study of dwarf elliptical galaxies in the Virgo Cluster: kinematics and stellar populations

Dwarf elliptical galaxies (dEs) are the most common galaxy type in nearby galaxy clusters; even so, many of their basic properties have yet to be quantified. Here we present the results of our study of 4 Virgo dwarf ellipticals obtained with the SAURON integral field unit on the William Herschel Telescope (La Palma, Spain). While traditional long-slit observations are likely to miss more complicated kinematic features, with SAURON we are able to study both kinematics and stellar populations in two dimensions, obtaining a much more detailed view of the mass distribution and star formation histories. What is visible even in such a small sample is that dEs are not a uniform group, not only morphologically, but also as far as their kinematic and stellar population properties are concerned. We find the presence of substructures, varying degrees of flattening and of rotation, as well as differences in age and metallicity gradients. We confirm that two of our galaxies are significantly flattened, yet non-rotating objects, which makes them likely triaxial systems. The comparison between the dwarf and the giant groups shows that dEs could be a low-mass extension of Es in the sense that they do seem to follow the same trends with mass. However, dEs as progenitors of Es seem less likely as we have seen that dEs have much lower abundance ratios.Comment: 8 pages, 6 figures; to appear in the proceedings of the JENAM 2010 Symposium on Dwarf Galaxies (Lisbon, September 9-10, 2010); minor edits and references adde

Omalizumab may decrease IgE synthesis by targeting membrane IgE+ human B cells

Omalizumab, is a humanized anti-IgE monoclonal antibody used to treat allergic asthma. Decreased serum IgE levels, lower eosinophil and B cell counts have been noted as a result of treatment. In vitro studies and animal models support the hypothesis that omalizumab inhibits IgE synthesis by B cells and causes elimination of IgE-expressing cells either by induction of apoptosis or induction of anergy or tolerance. METHODS: We examined the influence of omalizumab on human tonsillar B cell survival and on the genes involved in IgE synthesis. Tonsillar B cells were stimulated with IL-4 plus anti-CD40 antibody to induce class switch recombination to IgE production in the presence or absence of omalizumab. Cell viability was assessed and RNA extracted to examine specific genes involved in IgE synthesis. CONCLUSIONS: We found that omalizumab reduced viable cell numbers but this was not through induction of apoptosis. IL-4R and germline Cϵ mRNA levels were decreased as well as the number of membrane IgE+ cells in B cells treated with omalizumab. These data suggest that omalizumab may decrease IgE synthesis by human B cells by specifically targeting membrane IgE-bearing B cells and inducing a state of anergy

A review of elliptical and disc galaxy structure, and modern scaling laws

A century ago, in 1911 and 1913, Plummer and then Reynolds introduced their models to describe the radial distribution of stars in `nebulae'. This article reviews the progress since then, providing both an historical perspective and a contemporary review of the stellar structure of bulges, discs and elliptical galaxies. The quantification of galaxy nuclei, such as central mass deficits and excess nuclear light, plus the structure of dark matter halos and cD galaxy envelopes, are discussed. Issues pertaining to spiral galaxies including dust, bulge-to-disc ratios, bulgeless galaxies, bars and the identification of pseudobulges are also reviewed. An array of modern scaling relations involving sizes, luminosities, surface brightnesses and stellar concentrations are presented, many of which are shown to be curved. These 'redshift zero' relations not only quantify the behavior and nature of galaxies in the Universe today, but are the modern benchmark for evolutionary studies of galaxies, whether based on observations, N-body-simulations or semi-analytical modelling. For example, it is shown that some of the recently discovered compact elliptical galaxies at 1.5 < z < 2.5 may be the bulges of modern disc galaxies.Comment: Condensed version (due to Contract) of an invited review article to appear in "Planets, Stars and Stellar Systems"(www.springer.com/astronomy/book/978-90-481-8818-5). 500+ references incl. many somewhat forgotten, pioneer papers. Original submission to Springer: 07-June-201

The clinical utility of molecular diagnostic testing for primary immune deficiency disorders: a case based review

Primary immune deficiency disorders (PIDs) are a group of diseases associated with a genetic predisposition to recurrent infections, malignancy, autoimmunity and allergy. The molecular basis of many of these disorders has been identified in the last two decades. Most are inherited as single gene defects. Identifying the underlying genetic defect plays a critical role in patient management including diagnosis, family studies, prognostic information, prenatal diagnosis and is useful in defining new diseases. In this review we outline the clinical utility of molecular testing for these disorders using clinical cases referred to Auckland Hospital. It is written from the perspective of a laboratory offering a wide range of tests for a small developed country

Hemispheric Asymmetry in White Matter Connectivity of the Temporoparietal Junction with the Insula and Prefrontal Cortex

The temporoparietal junction (TPJ) is a key node in the brain's ventral attention network (VAN) that is involved in spatial awareness and detection of salient sensory stimuli, including pain. The anatomical basis of this network's right-lateralized organization is poorly understood. Here we used diffusion-weighted MRI and probabilistic tractography to compare the strength of white matter connections emanating from the right versus left TPJ to target regions in both hemispheres. Symmetry of structural connectivity was evaluated for connections between TPJ and target regions that are key cortical nodes in the right VAN (insula and inferior frontal gyrus) as well as target regions that are involved in salience and/or pain (putamen, cingulate cortex, thalamus). We found a rightward asymmetry in connectivity strength between the TPJ and insula in healthy human subjects who were scanned with two different sets of diffusion-weighted MRI acquisition parameters. This rightward asymmetry in TPJ-insula connectivity was stronger in females than in males. There was also a leftward asymmetry in connectivity strength between the TPJ and inferior frontal gyrus, consistent with previously described lateralization of language pathways. The rightward lateralization of the pathway between the TPJ and insula supports previous findings on the roles of these regions in stimulus-driven attention, sensory awareness, interoception and pain. The findings also have implications for our understanding of acute and chronic pains and stroke-induced spatial hemineglect

Astro2020 Science White Paper: Construction of an L* Galaxy: the Transformative Power of Wide Fields for Revealing the Past, Present and Future of the Great Andromeda System

The Great Andromeda Galaxy (M31) is the nexus of the near-far galaxy evolution connection and a principal data point for near-field cosmology. Due to its proximity (780 kpc), M31 can be resolved into individual stars like the Milky Way (MW). Unlike the MW, we have the advantage of a global view of M31, enabling M31 to be observed with techniques that also apply to more distant galaxies. Moreover, recent evidence suggests that M31 may have survived a major merger within the last several Gyr, shaping the morphology of its stellar halo and triggering a starburst, while leaving the stellar disk largely intact. The MW and M31 thus provide complementary opportunities for in-depth studies of the disks, halos, and satellites of L* galaxies. Our understanding of the M31 system will be transformed in the 2020s if they include wide field facilities for both photometry (HST-like sensitivity and resolution) and spectroscopy (10-m class telescope, >1 sq. deg. field, highly multiplexed, R~ 3000 to 6000). We focus here on the power of these facilities to constrain the past, present, and future merger history of M31, via chemo-dynamical analyses and star formation histories of phase-mixed stars accreted at early times, as well as stars in surviving tidal debris features, M31's extended disk, and intact satellite galaxies that will eventually be tidally incorporated into the halo. This will yield an unprecedented view of the hierarchical formation of the M31 system and the subhalos that built it into the L* galaxy we observe today

Menopausal hot flushes and night sweats: where are we now?

Objective An overview of the current knowledge on the etiology and treatment of vasomotor symptoms in postmenopausal women. Materials and methods Acknowledged experts in the field contributed a brief assessment of their areas of interest which were combined and edited into the final manuscript. Results Women around the world experience vasomotor symptoms as they enter and complete the menopause transition. Vasomotor symptoms, specifically hot flushes, are caused by a narrowing of the thermoneutral zone in the brain. This effect, although related to estrogen withdrawal, is most likely related to changes in central nervous system neurotransmitters. Peripheral vascular reactivity is also altered in symptomatic women. Estrogen replacement therapy is the most effective treatment for hot flushes. Of the other interventions investigated, selective serotonin and selective norepinephrine reuptake inhibitors and gabapentin show efficacy greater than placebo. Objective monitoring of hot flushes indicates a robust improvement with hormone replacement therapy but little to no change with placebo. These data suggest that the subjective assessment of responses to therapy for vasomotor symptom results in inaccurate data. Hot flushes have recently been associated with increased cardiovascular risks and a lower incidence of breast cancer, but these data require confirmation. Conclusions Vasomotor symptoms are experienced by women of all ethnic groups. They are caused by changes in the central nervous system associated with estrogen withdrawal and are best treated with estrogen replacement therapy. Objective monitoring of hot flushes indicates that placebo has little to no effect on their improvement. Subjective assessments of hot flushes in clinical trials may be inaccurate based on objective measurement of the frequency of hot flushes. Based on preliminary reports, women experiencing hot flushes have an increased risk of cardiovascular disease and a reduced incidence of breast cance