‘Devolution and Cultural Catch-Up: Decoupling England and its Literature from English Literature’

Robert McLiam Wilson’s 1989 novel Ripley Bogle uses an unreliable narrator to expose the differences – regional, linguistic and national – between communities Bogle, the protagonist, experiences in Cambridge and Northern Ireland. Bogle is an English Literature student and then drop-out whose rejection of canonical study is the rejection of Arnoldianism and a traditionally organist and imperialist discipline that reanimates the debate about civic values and literary culture. A similar device is used in Sebastian Faulks’s 2007 novel Engleby in which Mike Engleby abandons English Literature at University only to later become a journalist probing the political landscape and personalities of the 1980s and after. Embroiled in disappearance and death, Engleby’s psychological unpredictability enables a reading of Britain’s socio-political death. These interconnected novels stand either side of Britain’s devolutionary divide and, as a pair, are suggestive of England’s need to readdress its own literary culture in the face of devolution. They are also symptomatic of a wider cultural catch-up required within England after 1999. Where the other devolved nations have sought to advance new and challenging national literary concerns and forms distinct from the pan-British literary canon of the past (and its restrictive exclusion based on class, gender and race), England has only recently come to view its literary culture as national. However, this has provided a potential filled moment of redefinition that will help free England and its authors from the pan-British sensibility of imperial dominance. This chapter argues that such redefinition, and resistance to the canon, developed immediately before and dramatically after devolution is evident in Graham Swift’s Last Orders (1996) with its resistive yet civic working class community and in the representations of marginalised, disempowered sections of England’s population offered in Alan Kent’s Proper Job, Charlie Kurnow (2005), Stella Duffy’s The Room of Lost Things (2009) and Jim Crace’s All That Follows (2010). These authors seize the opportunity provided by devolution to re-examine England’s national identity and to probe its relation to political enfranchisement, civic responsibility and literary vitality as England culturally catches up with its own socio-political reality

Health Conditions and Their Impact among Adolescents and Young Adults with Down Syndrome

Objective: To examine the prevalence of medical conditions and use of health services among young adults with Down syndrome and describe the impact of these conditions upon their lives. Methods: Using questionnaire data collected in 2011 from parents of young adults with Down syndrome we investigated the medical conditions experienced by their children in the previous 12 months. Univariate, linear and logistic regression analyses were performed. Results: We found that in addition to the conditions commonly experienced by children with Down syndrome, including eye and vision problems (affecting 73%), ear and hearing problems (affecting 45%), cardiac (affecting 25%) and respiratory problems (affecting 36%), conditions also found to be prevalent within our young adult cohort included musculoskeletal conditions (affecting 61%), body weight (affecting 57%), skin (affecting 56%) and mental health (affecting 32%) conditions and among young women menstrual conditions (affecting 58%). Few parents reported that these conditions had no impact, with common impacts related to restrictions in opportunities to participate in employment and community leisure activities for the young people, as well as safety concerns. Conclusion: There is the need to monitor, screen and provide appropriate strategies such as through the promotion of healthy lifestyles to prevent the development of comorbidities in young people with Down syndrome and, where present, to reduce their impact

The role of the carotenoids, lutein and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence

PURPOSE: A review of the role of the carotenoids, lutein and zeaxanthin, and their function in altering the pathogenesis of age-related macular degeneration (AMD). METHODS: Medline and Embase search. RESULTS: Recent evidence introduces the possibility that lutein and zeaxanthin, carotenoids found in a variety of fruits and vegetables may protect against the common eye disease of macular degeneration. This potential and the lack to slow the progression of macular degeneration, has fueled high public interest in the health benefits of these carotenoids and prompted their inclusion in various supplements. The body of evidence supporting a role in this disease ranges from basic studies in experimental animals to various other clinical and epidemiological studies. Whilst some epidemiological studies suggest a beneficial role for carotenoids in the prevention of AMD, others are found to be unrelated to it. Results of some clinical studies indicate that the risk for AMD is reduced when levels of the carotenoids are elevated in the serum or diet, but this correlation is not observed in other studies. Published data concerning the toxicity of the carotenoids or the optimum dosage of these supplements is lacking. CONCLUSION: An intake of dietary supplied nutrients rich in the carotenoids, lutein and zeaxanthin, appears to be beneficial in protecting retinal tissues, but this is not proven. Until scientifically sound knowledge is available we recommend for patients judged to be at risk for AMD to: alter their diet to more dark green leafy vegetables, wear UV protective lenses and a hat when outdoors. Future investigations on the role of nutrition, light exposure, genetics, and combinations of photodynamic therapy with intravitreal steroid (triamcinolone-acetonide) injections hold potential for future treatment possibilities

The effects of processing and mastication on almond lipid bioaccessibility using novel methods of in vitro digestion modelling and micro-structural analysis.

A number of studies have demonstrated that consuming almonds increases satiety but does not result in weight gain, despite their high energy and lipid content. To understand the mechanism of almond digestion, in the present study, we investigated the bioaccessibility of lipids from masticated almonds during in vitro simulated human digestion, and determined the associated changes in cell-wall composition and cellular microstructure. The influence of processing on lipid release was assessed by using natural raw almonds (NA) and roasted almonds (RA). Masticated samples from four healthy adults (two females, two males) were exposed to a dynamic gastric model of digestion followed by simulated duodenal digestion. Between 7·8 and 11·1 % of the total lipid was released as a result of mastication, with no significant differences between the NA and RA samples. Significant digestion occurred during the in vitro gastric phase (16·4 and 15·9 %) and the in vitro duodenal phase (32·2 and 32·7 %) for the NA and RA samples, respectively. Roasting produced a smaller average particle size distribution post-mastication; however, this was not significant in terms of lipid release. Light microscopy showed major changes that occurred in the distribution of lipid in all cells after the roasting process. Further changes were observed in the surface cells of almond fragments and in fractured cells after exposure to the duodenal environment. Almond cell walls prevented lipid release from intact cells, providing a mechanism for incomplete nutrient absorption in the gut. The composition of almond cell walls was not affected by processing or simulated digestion