16 research outputs found
Longitudinal analysis of peripheral blood T cell receptor diversity in patients with systemic lupus erythematosus by next-generation sequencing
Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase
Potential of Environmental DNA to Evaluate Northern Pike (Esox lucius) Eradication Efforts: An Experimental Test and Case Study
Lower Circulating Androgens Are Associated with Overall Cancer Risk and Prostate Cancer Risk in Men Aged 25–84 Years from the Busselton Health Study
Opinions of Speech-Language Pathologists Regarding Speech Management for Children With Cleft Lip and Palate
The association of diabetes and obesity with prostate cancer aggressiveness among Black Americans and White Americans in a population-based study
PURPOSE: Few studies have investigated the role of race in the association of diabetes and obesity with prostate cancer aggressiveness. Here we evaluate the independent association between diabetes and obesity with prostate cancer aggressiveness in White Americans and Black Americans. METHODS: Our cross-sectional, case-only study consisted of 1058 White Americans and 991 Black Americans from the North Carolina-Louisiana Prostate Cancer (PCaP) project. Diabetes status was determined by self-report. Obesity was determined using body mass index and calculated based on anthropometric measurements. High aggressive prostate cancer was defined as Gleason sum ≥8, or prostate specific antigen >20 ng/ml, or Gleason sum =7 and clinical stage cT3-cT4. The association between diabetes and obesity with high aggressive prostate cancer at diagnosis was evaluated using multivariable logistic regression and adjusted for potential confounders. RESULTS: Diabetes was not associated with high aggressive prostate cancer in the overall sample (OR: 1.04; 95% CI: 0.79, 1.37), White Americans (OR: 1.00; 95% CI: 0.65, 1.57), or Black Americans (OR: 1.07; 95% CI: 0.75, 1.53). Obesity, independent of diabetes, was positively associated with high aggressive prostate cancer in White Americans (OR: 1.98; 95% CI: 1.14, 3.43), but not in the overall sample (OR: 1.37; 95% CI: 0.99, 1.92) or Black Americans (OR: 1.09; 95% CI: 0.71, 1.67). CONCLUSIONS: Diabetes was not associated with prostate cancer aggressiveness, overall, or in either race-group. Obesity, independent of diabetes, was associated with high aggressive prostate cancer only in White Americans