“Till at last there remain nothing”

In A Treatise of Human Nature, David Hume presents an argument according to which all knowledge reduces to probability, and all probability reduces to nothing. Many have criticized this argument, while others find nothing wrong with it. In this paper we explain that the argument is invalid as it stands, but for different reasons than have been hitherto acknowledged. Once the argument is repaired, it becomes clear that there is indeed something that reduces to nothing, but it is something other than what, according to many, Hume had in mind. Thus two views emerge of what exactly it is that reduces. We surmise that Hume failed to distinguish the two, because he lacked the formal means to differentiate between a rendering of his argument that is in accordance with the probability calculus, and one that is not

The structure of idealization in biological theories: the case of the Wright-Fisher model.

In this paper we present a new framework of idealization in biology. We characterize idealizations as a network of counterfactual and hypothetical conditionals that can exhibit different “degrees of contingency”. We use this idea to say that, in departing more or less from the actual world, idealizations can serve numerous epistemic, methodological or heuristic purposes within scientific research. We defend that, in part, this structure explains why idealizations, despite being deformations of reality, are so successful in scientific practice. For illustrative purposes, we provide an example from population genetics, the Wright-Fisher Mode