America's pyramids: Presidents and their libraries

Review of the purpose, history, and debates about the presidential library system, with a recommendation to end the system

Testing the spirit of the information age

Every age has a 'spirit," The Information Age seems to be a more extreme case than most eras, with the constant barrage of messages promising social and individual salvation. Information and information technology are heralded as\ud great, new possibilities not just for reform but perfection, with some even predicting the end of physical death (using information technology. by the end of the next century. The intensity of our current period's fascination with technology is partly due to the technology itself-ideas or sales pitches get out to more people more quickly than ever before in history, and, as a result it\ud is easy to be blinded by all the promises and hype. It is no accident that ideas like "ecommerce" and "knowledge management' are unifying concepts for many in this era, but although there is nothing intrinsically wrong with them, there is something amiss with how they are discussed. This essay comments on the latter issue, the hyperbole of the Information Age, from three perspectives: 1) as a consumer of information technology; 2) as an educator in a field (archives and records management) utilizing information technology; and 3) as an individual convinced about the relevancy of basic Judaic-Christian beliefs as one means to shift critically the many conflicting and confusing messages promulgated by the so-called modern Information\ud Age

Revisiting the archival finding aid

Archivists have been creating finding aids for generations, and in the last three decades they have done this work via a succession of standardized formats. However, like many other disciplines, they have carried out such work in violation of systems analysis. Although purporting to have the users of finding aids systems first and foremost in their mind, archivists have carried out their descriptive work apart from and with little knowledge of how researchers find and use archival sources. In this article, questions are raised about the utility of archival finding aids and how they will stand the test of time. Indeed, archivists, purportedly concerned with considering how records function and will be used over time, ought to apply the same kind of analysis and thinking to their finding aids. In this article, we explore three ways archival finding aids might be examined by outsiders, namely, those concerned with museum exhibitions, design experts, and accountability advocates. Doing this should assist archivists to reevaluate their next wave of experimentation with descriptive standards and the construction of finding aids. Archivists should expand the notion of what we are representing in archival representation. © 2007 by The Haworth Press

Ensembles based on the Rich-Club and how to use them to build soft-communities

16 pages, 5 figures16 pages, 5 figures16 pages, 5 figuresEnsembles of networks are used as null-models to discriminate network structures. We present an efficient algorithm, based on the maximal entropy method to generate network ensembles defined by the degree sequence and the rich-club coefficient. The method is applicable for unweighted, undirected networks. The ensembles are used to generate correlated and uncorrelated null--models of a real networks. These ensembles can be used to define the partition of a network into soft communities

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection

Bioactive matrix fragments (matrikines) have been identified in a myriad of disorders, but their impact on the evolution of airway inflammation has not been demonstrated. We recently described a pathway where the matrikine and neutrophil chemoattractant proline–glycine–proline (PGP) could be degraded by the enzyme leukotriene A4 hydrolase (LTA4H). LTA4H classically functions in the generation of pro-inflammatory leukotriene B4, thus LTA4H exhibits opposing pro- and anti-inflammatory activities. The physiological significance of this secondary anti-inflammatory activity remains unknown. Here we show, using readily resolving pulmonary inflammation models, that loss of this secondary activity leads to more pronounced and sustained inflammation and illness owing to PGP accumulation. PGP elicits an exacerbated neutrophilic inflammation and protease imbalance that further degrades the extracellular matrix, generating fragments that perpetuate inflammation. This highlights a critical role for the secondary anti-inflammatory activity of LTA4H and thus has consequences for the generation of global LTA4H inhibitors currently being developed

Gait analysis methods in rehabilitation

Introduction: Brand's four reasons for clinical tests and his analysis of the characteristics of valid biomechanical tests for use in orthopaedics are taken as a basis for determining what methodologies are required for gait analysis in a clinical rehabilitation context. Measurement methods in clinical gait analysis: The state of the art of optical systems capable of measuring the positions of retro-reflective markers placed on the skin is sufficiently advanced that they are probably no longer a significant source of error in clinical gait analysis. Determining the anthropometry of the subject and compensating for soft tissue movement in relation to the under-lying bones are now the principal problems. Techniques for using functional tests to determine joint centres and axes of rotation are starting to be used successfully. Probably the last great challenge for optical systems is in using computational techniques to compensate for soft tissue measurements. In the long term future it is possible that direct imaging of bones and joints in three dimensions (using MRI or fluoroscopy) may replace marker based systems. Methods for interpreting gait analysis data: There is still not an accepted general theory of why we walk the way we do. In the absence of this, many explanations of walking address the mechanisms by which specific movements are achieved by particular muscles. A whole new methodology is developing to determine the functions of individual muscles. This needs further development and validation. A particular requirement is for subject specific models incorporating 3-dimensional imaging data of the musculo-skeletal anatomy with kinematic and kinetic data. Methods for understanding the effects of intervention: Clinical gait analysis is extremely limited if it does not allow clinicians to choose between alternative possible interventions or to predict outcomes. This can be achieved either by rigorously planned clinical trials or using theoretical models. The evidence base is generally poor partly because of the limited number of prospective clinical trials that have been completed and more such studies are essential. Very recent work has started to show the potential of using models of the mechanisms by which people with pathology walk in order to simulate different potential interventions. The development of these models offers considerable promise for new clinical applications of gait analysis

Public records in Colonial Maryland

Historical analysis of the efforts to create, maintain, and use the records of the administration of the colony of Maryland