SUPPLY CHAINS MAY DELIVER SAFER TOMATOES AND STRAWBERRIES

Food Consumption/Nutrition/Food Safety,

FLORIDA DAIRY MARKETING COOPERATIVES' TRANSFER COST ASSOCIATED WITH NON-UNIFORM DELIVERY SCHEDULES

The economic basis for alternative delivery schedules between Florida Dairy Marketing Cooperatives (FDMCs) and fluid milk processors are analyzed, and the costs and benefits of improved coordination between these two market stages are highlighted. The additional costs incurred by FDMCs were they to switch from a uniform delivery schedule to various non-uniform delivery schedules are discussed. The seven-day uniform delivery schedule with the $0.25 discount scheme on total volume decreases FDMCs'Â’ net revenues by$0.1433 per hundredweight (cwt), compared to a five-day delivery schedule with no price discounts.Agribusiness,

Small Molecule Tyrosine Kinase Inhibitors of ErbB2/HER2/Neu in the Treatment of Aggressive Breast Cancer.

he human epidermal growth factor receptor 2 (HER2) is a member of the erbB class of tyrosine kinase receptors. These proteins are normally expressed at the surface of healthy cells and play critical roles in the signal transduction cascade in a myriad of biochemical pathways responsible for cell growth and differentiation. However, it is widely known that amplification and subsequent overexpression of the HER2 encoding oncogene results in unregulated cell proliferation in an aggressive form of breast cancer known as HER2-positive breast cancer. Existing therapies such as trastuzumab (Herceptin®) and lapatinib (Tyverb/Tykerb®), a monoclonal antibody inhibitor and a dual EGFR/HER2 kinase inhibitor, respectively, are currently used in the treatment of HER2-positive cancers, although issues with high recurrence and acquired resistance still remain. Small molecule tyrosine kinase inhibitors provide attractive therapeutic targets, as they are able to block cell signaling associated with many of the proposed mechanisms for HER2 resistance. In this regard we aim to present a review on the available HER2 tyrosine kinase inhibitors, as well as those currently in development. The use of tyrosine kinase inhibitors as sequential or combinatorial therapeutic strategies with other HER family inhibitors is also discussed

Nature does not rely on long-lived electronic quantum coherence for photosynthetic energy transfer

During the first steps of photosynthesis, the energy of impinging solar photons is transformed into electronic excitation energy of the light-harvesting biomolecular complexes. The subsequent energy transfer to the reaction center is commonly rationalized in terms of excitons moving on a grid of biomolecular chromophores on typical timescales [Formula: see text]100 fs. Today's understanding of the energy transfer includes the fact that the excitons are delocalized over a few neighboring sites, but the role of quantum coherence is considered as irrelevant for the transfer dynamics because it typically decays within a few tens of femtoseconds. This orthodox picture of incoherent energy transfer between clusters of a few pigments sharing delocalized excitons has been challenged by ultrafast optical spectroscopy experiments with the Fenna-Matthews-Olson protein, in which interference oscillatory signals up to 1.5 ps were reported and interpreted as direct evidence of exceptionally long-lived electronic quantum coherence. Here, we show that the optical 2D photon echo spectra of this complex at ambient temperature in aqueous solution do not provide evidence of any long-lived electronic quantum coherence, but confirm the orthodox view of rapidly decaying electronic quantum coherence on a timescale of 60 fs. Our results can be considered as generic and give no hint that electronic quantum coherence plays any biofunctional role in real photoactive biomolecular complexes. Because in this structurally well-defined protein the distances between bacteriochlorophylls are comparable to those of other light-harvesting complexes, we anticipate that this finding is general and directly applies to even larger photoactive biomolecular complexes

Boundary layer structure in turbulent thermal convection and its consequences for the required numerical resolution

Results on the Prandtl-Blasius type kinetic and thermal boundary layer thicknesses in turbulent Rayleigh-B\'enard convection in a broad range of Prandtl numbers are presented. By solving the laminar Prandtl-Blasius boundary layer equations, we calculate the ratio of the thermal and kinetic boundary layer thicknesses, which depends on the Prandtl number Pr only. It is approximated as $0.588Pr^{-1/2}$ for $Pr\ll Pr^*$ and as $0.982 Pr^{-1/3}$ for $Pr^*\ll\Pr$, with $Pr^*= 0.046$. Comparison of the Prandtl--Blasius velocity boundary layer thickness with that evaluated in the direct numerical simulations by Stevens, Verzicco, and Lohse (J. Fluid Mech. 643, 495 (2010)) gives very good agreement. Based on the Prandtl--Blasius type considerations, we derive a lower-bound estimate for the minimum number of the computational mesh nodes, required to conduct accurate numerical simulations of moderately high (boundary layer dominated) turbulent Rayleigh-B\'enard convection, in the thermal and kinetic boundary layers close to bottom and top plates. It is shown that the number of required nodes within each boundary layer depends on Nu and Pr and grows with the Rayleigh number Ra not slower than \sim\Ra^{0.15}. This estimate agrees excellently with empirical results, which were based on the convergence of the Nusselt number in numerical simulations

Comparison of computational codes for direct numerical simulations of turbulent Rayleigh-B\'enard convection

Computational codes for direct numerical simulations of Rayleigh-B\'enard (RB) convection are compared in terms of computational cost and quality of the solution. As a benchmark case, RB convection at $Ra=10^8$ and $Pr=1$ in a periodic domain, in cubic and cylindrical containers is considered. A dedicated second-order finite-difference code (AFID/RBflow) and a specialized fourth-order finite-volume code (Goldfish) are compared with a general purpose finite-volume approach (OpenFOAM) and a general purpose spectral-element code (Nek5000). Reassuringly, all codes provide predictions of the average heat transfer that converge to the same values. The computational costs, however, are found to differ considerably. The specialized codes AFID/RBflow and Goldfish are found to excel in efficiency, outperforming the general purpose flow solvers Nek5000 and OpenFOAM by an order of magnitude with an error on the Nusselt number $Nu$ below $5\%$. However, we find that $Nu$ alone is not sufficient to assess the quality of the numerical results: in fact, instantaneous snapshots of the temperature field from a near wall region obtained for deliberately under-resolved simulations using Nek5000 clearly indicate inadequate flow resolution even when $Nu$ is converged. Overall, dedicated special purpose codes for RB convection are found to be more efficient than general purpose codes.Comment: 12 pages, 5 figure

Impact of Changes to National Hypertension Guidelines on Hypertension Management and Outcomes in the United Kingdom.

In recent years, national and international guidelines have recommended the use of out-of-office blood pressure monitoring for diagnosing hypertension. Despite evidence of cost-effectiveness, critics expressed concerns this would increase cardiovascular morbidity. We assessed the impact of these changes on the incidence of hypertension, out-of-office monitoring and cardiovascular morbidity using routine clinical data from English general practices, linked to inpatient hospital, mortality, and socio-economic status data. We studied 3 937 191 adults with median follow-up of 4.2 years (49% men, mean age=39.7 years) between April 1, 2006 and March 31, 2017. Interrupted time series analysis was used to examine the impact of changes to English hypertension guidelines in 2011 on incidence of hypertension (primary outcome). Secondary outcomes included rate of out-of-office monitoring and cardiovascular events. Across the study period, incidence of hypertension fell from 2.1 to 1.4 per 100 person-years. The change in guidance in 2011 was not associated with an immediate change in incidence (change in rate=0.01 [95% CI, -0.18-0.20]) but did result in a leveling out of the downward trend (change in yearly trend =0.09 [95% CI, 0.04-0.15]). Ambulatory monitoring increased significantly in 2011/2012 (change in rate =0.52 [95% CI, 0.43-0.60]). The rate of cardiovascular events remained unchanged (change in rate =-0.02 [95% CI, -0.05-0.02]). In summary, changes to hypertension guidelines in 2011 were associated with a stabilisation in incidence and no increase in cardiovascular events. Guidelines should continue to recommend out-of-office monitoring for diagnosis of hypertension