Management and treatment of sinonasal inverted papilloma

Aims: The aim of this paper is to describe the surgical experience of 35 patients with Inverted Papilloma (IP) of paranasal sinuses and its recurrence rate after a year of follow-up. Materials: A retrospective chart review was performed on patients presenting with IP of paranasal sinuses. Thirty-five patients comprised the focus of this study. For all patients was performed a pre-surgery TC, and for more 5 patients it was necessary to perform a Magnetic Resonance (MR) with gadolinium. Results: Among 35 patients selected, 18 patients underwent to open surgery, 4 patients had a combined approach with endoscopy and open surgery, while 13 patients were managed only with an endoscopic approach, with a minimum of 1 year of follow-up. Our results highlighted that the global percentage of success 12 months after the treatment was 93% and it not vary according to the tipology of the approach used if a radical excision of the lesion is achieved. More in depth, among 35 cases, only 2 patients were found to have recurrences and were treated with coronal and endoscopic approach. Conclusion: It is fundamental to underline that surgery must be carried on in a radical manner to treat these tend to recur. A complete removal of the lesion and bone peripheral border filing are essential to perform a correct and definitive treatment. Also, endoscopic approach can be taken into account when tumors are localized median to a sagittal plan crossing the orbit median wall and when they did not massively compromised paranasal sinus walls

Aesthetic restoration in maxillo-mandibular malformations: the role of genioplasty

Aim: The aim of this study was to determinate how orthognatic surgery aids to cure many skull and face abnormalities and to help re-establishing the correct occlusive relation thanks to the repositioning of the maxillo-mandibular skeleton basis. Methods: The study included 183 male patients and 338 female patients, with an average age of 23 years. The sample series was divided according to specific pathologies. All patients underwent surgical procedures and the therapeutic strategy was determined based on the anomalies presented. Results: 113 patients had a II class dental skeletal occlusion, 180 patients had a III class dental-skeletal occlusion and 222 patients had skull-facial abnormalities. 5 patients underwent only a genioplasty, 82 patients underwent a genioplasty associated with BSSO, 175 patients underwent a genioplasty associated with Le Fort I osteotomy and the remaining 253 patients underwent a genioplasty associated with BSSO and Le Fort I osteotomy. Conclusion: The experience shows that genioplasty has been successfully introduced in orthognathic surgical therapeutic procedures, for dental-skeleton abnormalities and mandibular asymmetries treatment. In recent years, the evolution of computer systems has allowed an accurate assessment and programming, by means of the three-dimensional display, which are of great help in the course of diagnosis and evaluation of the displacements to be carried out, in order to obtain optimal aesthetic results

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein

Prion diseases are rare neurodegenerative conditions associated with the conformational conversion of the cellular prion protein (PrPC) into PrPSc, a self-replicating isoform (prion) that accumulates in the central nervous system of affected individuals. The structure of PrPSc is poorly defined, and likely to be heterogeneous, as suggested by the existence of different prion strains. The latter represents a relevant problem for therapy in prion diseases, as some potent anti-prion compounds have shown strain-specificity. Designing therapeutics that target PrPC may provide an opportunity to overcome these problems. PrPC ligands may theoretically inhibit the replication of multiple prion strains, by acting on the common substrate of any prion replication reaction. Here, we characterized the properties of a cationic tetrapyrrole [Fe(III)-TMPyP], which was previously shown to bind PrPC, and inhibit the replication of a mouse prion strain. We report that the compound is active against multiple prion strains in vitro and in cells. Interestingly, we also find that Fe(III)-TMPyP inhibits several PrPC-related toxic activities, including the channel-forming ability of a PrP mutant, and the PrPC-dependent synaptotoxicity of amyloid-beta (A beta) oligomers, which are associated with Alzheimer's Disease. These results demonstrate that molecules binding to PrPC may produce a dual effect of blocking prion replication and inhibiting PrPC-mediated toxicity

Design and status of the NGS WFS of MAORY

MAORY is the first-light multi-conjugate AO facility of the E-ELT, providing a >30% Strehl ratio (evaluated inK band, median seeing conditions) over the MICADO 53 ×53 arcsec FoV and ensuring an overall sky coverageof 50%. MAORY will implement 3 NGS WFS having a double functionality: sensing the atmospheric low-ordermodes (LO-WFS) and de-trending the LGS WFS measurements (Ref-WFS).To maximize the AO sky-coverage the preliminary design of the LO-WFS foresees a 2×2 subapertures Shack-Hartmann sensor working in the H band, where the partial AO-correction regime and the low-noise detectorsbased on APD technology will enhance the WFS sensitivity. The Reference WFS will measure at slow rate(1÷10 s) the first ∼100 modes of the atmospheric aberration and it will correct the LGS measurements that areaffected by the Sodium layer drifts. The Ref-WFS will be a 10×10 SH making use of a CCD220-based detector.Hence it will work at visibile wavelenghts, using the same NGS of the LO-WFS.We present here the results of a study aimed to find the best design solutions for the MAORY NGS WFSin preparation of the project preliminary design review of scheduled in February 2018. We describe first theoutput of numerical simulations to find the best compromise between the working bandwidth and sampling of theLO-WFS and the sky-coverage corresponding to the expected performance. Then we describe the arrangementfor the NGS WFS module, hosted on top of the MICADO cryostat, analyzing the static and dynamic propertiesof the NGS module structure. Finally we present the opto-mechanical layout for the NGS WFS and its degreesof freedom

T-REX Operating Unit 3

OU3 is one of the six Operating Units of the Progetto Premiale T-REX. It is focused on the development of adaptive optics instrumentation for the European Extremely Large Telescope. The main activities of OU3 are the MAORY adaptive optics module, the MICADO infrared camera, the characterisation and forecast of atmospheric parameters for the E-ELT site and general developments for future adaptive optics systems. <P /

The MAORY first-light adaptive optics module for E-ELT

The MAORY adaptive optics module is part of the first light instrumentation suite for the E-ELT. The MAORY project phase B is going to start soon. This paper contains a system-level overview of the current instrument design

MAORY: adaptive optics module for the E-ELT

MAORY is one of the four instruments for the E-ELT approved for construction. It is an adaptive optics module offering two compensation modes: multi-conjugate and single-conjugate adaptive optics. The project has recently entered its phase B. A system-level overview of the current status of the project is given in this paper

Proceedings of the Fifth Italian Conference on Computational Linguistics CLiC-it 2018

On behalf of the Program Committee, a very warm welcome to the Fifth Italian Conference on Computational Linguistics (CLiC-­‐it 2018). This edition of the conference is held in Torino. The conference is locally organised by the University of Torino and hosted into its prestigious main lecture hall “Cavallerizza Reale”. The CLiC-­‐it conference series is an initiative of the Italian Association for Computational Linguistics (AILC) which, after five years of activity, has clearly established itself as the premier national forum for research and development in the fields of Computational Linguistics and Natural Language Processing, where leading researchers and practitioners from academia and industry meet to share their research results, experiences, and challenges

Our experience in complications of orthognathic surgery: a retrospective study on 3236 patients

From 1989 to 2009, at the Department of Cranio-Maxillo-Facial Surgery, Umberto I Polyclinic, "Sapienza" University of Rome, 3236 patients affected by maxillo-mandibular malformations were submitted to orthognathic surgery, by means of rigid internal fixation. Follow-up highlighted the surgical complications and the possible functional and/or esthetical disorders in the treatment of those pathologies. The data collected have been compared with the ones reported in the literature

Endoscopic approach to maxillo-facial trauma

AIM: This article reviews the application of endoscope-assisted techniques to the treatment of maxillofacial trauma and discusses some aspects of these techniques and reporting our experience INTRODUCTION: In the last decades, diagnostical imaging, surgical techniques and surgical instrument development allowed a great progress in management of facial fractures. In recent years, to some Authors, endoscopic approach to maxillofacial trauma has become common for reducing zygomatic arch, orbital blow-out, medial orbital wall, frontal sinus and subcondylar mandibular fractures. The endoscopic reduction of facial fractures as an alternative to open reduction allowed to manage patients with less unwanted complications. In fact, endoscopic approach permit to dicrease perisurgical morbidity and offers to surgeons to reach good results. DISCUSSION: Indications, to endoscopic reduction are represented by dimension, extension and site of the fracture and to the surgeon's experience. CONCLUSIONS: The use of endoscopy in maxillo-facial surgery represents one of the main realities of modern medicine together with advanced sectors of biomedical engineering research. In this way, not only time of hospitalization will be reduced but also morbidity in maxillofacial surgery