10 research outputs found
Corporate Entrepreneurship:From Structures to Mindset
Corporate entrepreneurship dispersed throughout an organization and leveraging the entrepreneurial potential of all its employees bears significant benefits for those organizations that embrace it. However, it appears more difficult to instill and requires strong investment in the development of human capital and entrepreneurial mindset among the employees and across the organization. In this chapter, we discuss the essence of corporate entrepreneurship mindset and show that across an organization, there might be different entrepreneurial mindsets that correspond to different people, opportunities, and contexts. Although different, they all lead to enactment of entrepreneurial projects. This chapter, thus, contributes to the discussion regarding the nature of corporate entrepreneurial mindsets, and their development and stimulation within an organization, from both academic and practical view
Deflazacort vs prednisone treatment for Duchenne muscular dystrophy: A metaâanalysis of disease progression rates in recent multicenter clinical trials
Introduction: In this study we characterized disease progression over 48âweeks among boys receiving deflazacort vs prednisone/prednisolone placebo arm treatment in two recent Duchenne muscular dystrophy (DMD) clinical trials. /
Methods: Ambulatory boys with DMD receiving placebo in the phase 3 ataluren (N = 115) and tadalafil (N = 116) trials were included. The trials required at least 6âmonths of prior corticosteroid use and stable baseline dosing. Associations between corticosteroid use and 48âweek changes in ambulatory function were estimated using mixed models. Adjusted differences between corticosteroid groups were pooled in a metaâanalysis. /
Results: In the metaâanalysis, deflazacortâtreated patients vs prednisone/prednisoloneâtreated patients experienced, on average, lower declines of 28.3 meters on 6âminute walk distance (95% confidence interval [CI], 5.7, 50.9; 2.9âseconds on rise from supine [95% CI, 0.9, 4.9âseconds]; 2.3âseconds on 4âstair climb [95% CI, 0.5, 4.1âseconds]; and 2.9 [95% CI, 0.1, 5.8] points on the North Star Ambulatory Assessment linearized score). /
Discussion: Deflazacortâtreated patients experienced significantly lower functional decline over 48âweeks