82 research outputs found
Anti-inflammatory activity of Lychnophora passerina, Asteraceae (Brazilian “Arnica”)
AbstractEthnopharmacological relevanceLychnophora passerina (Asteraceae), popularly known as “arnica,” is used to treat inflammation, pain, rheumatism, contusions, bruises and insect bites in Brazilian traditional medicine.Materials and methodsThe anti-inflammatory activity of crude ethanolic extract of aerial parts of L. passerina and its ethyl acetate and methanolic fractions had their abilities to modulate the production of NO, TNF-α and IL-10 inflammatory mediators in LPS/IFN-γ-stimulated J774.A1 macrophages evaluated. Moreover, the crude ethanolic extract and derived fractions were also in vivo assayed by carrageenan-induced paw oedema in mice.ResultsIn vitro assays showed remarkable anti-inflammatory activity of L. passerina crude ethanolic extract (EE) and its ethyl acetate (A) and methanolic (M) fractions, through the inhibition of production of NO and TNF-α inflammatory mediators and induction of production of IL-10 anti-inflammatory cytokine. In vivo assays showed anti-inflammatory activity for EE 10% ointment, similar to the standard drug diclofenac gel. The A and M fraction ointments 20% presented anti-inflammatory activity.ConclusionThe results obtained showed that possible anti-inflammatory effects of EE and its A and M fractions may be attributed to inhibition pro-inflammatory cytokines production, TNF-α and NO and to increased IL-10 production. EE, A and M ointments showed topical in vivo anti-inflammatory activity. The in vivo anti-inflammatory activity of EE of L. passerina may be related to synergistic effects of different substances in the crude extract. Therefore, traditional use of aerial parts of L. passerina in the inflammatory conditions could be beneficial to treat topical inflammatory conditions, as evidenced by the present study
Desempenho dos diferentes modelos institucionais de prestação dos serviços públicos de abastecimento de água: uma avaliação comparativa no conjunto dos municípios brasileiros
Aspectos morfológicos macro e microscópicos do estômago de tamanduá-mirim (Tamandua tetradactyla)
Production and body composition traits of broilers in relation to breast weight evaluated by path analysis
Calcium levels and calcium: available phosphorus ratios in diets for white egg layers from 42 to 58 weeks of age
Teste de marcadores bioquímicos na identificação de prováveis indivíduos homozigotos dominantes para o gene tobiano em cavalos Pampa
Consumo e desempenho de ovinos alimentados com silagens de cana-de-açúcar tratadas com óxido de cálcio e cloreto de sódio
Aspectos florísticos e fitossociológicos de um trecho de Floresta Estacional Perenifólia na Fazenda Trairão, Bacia do rio das Pacas, Querência-MT
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