Bodyweight Perceptions among Texas Women: The Effects of Religion, Race/Ethnicity, and Citizenship Status

Despite previous work exploring linkages between religious participation and health, little research has looked at the role of religion in affecting bodyweight perceptions. Using the theoretical model developed by Levin et al. (Sociol Q 36(1):157–173, 1995) on the multidimensionality of religious participation, we develop several hypotheses and test them by using data from the 2004 Survey of Texas Adults. We estimate multinomial logistic regression models to determine the relative risk of women perceiving themselves as overweight. Results indicate that religious attendance lowers risk of women perceiving themselves as very overweight. Citizenship status was an important factor for Latinas, with noncitizens being less likely to see themselves as overweight. We also test interaction effects between religion and race. Religious attendance and prayer have a moderating effect among Latina non-citizens so that among these women, attendance and prayer intensify perceptions of feeling less overweight when compared to their white counterparts. Among African American women, the effect of increased church attendance leads to perceptions of being overweight. Prayer is also a correlate of overweight perceptions but only among African American women. We close with a discussion that highlights key implications from our findings, note study limitations, and several promising avenues for future research

Biallelic and monoallelic variants in PLXNA1 are implicated in a novel neurodevelopmental disorder with variable cerebral and eye anomalies.

PURPOSE: To investigate the effect of PLXNA1 variants on the phenotype of patients with autosomal dominant and recessive inheritance patterns and to functionally characterize the zebrafish homologs plxna1a and plxna1b during development. METHODS: We assembled ten patients from seven families with biallelic or de novo PLXNA1 variants. We describe genotype-phenotype correlations, investigated the variants by structural modeling, and used Morpholino knockdown experiments in zebrafish to characterize the embryonic role of plxna1a and plxna1b. RESULTS: Shared phenotypic features among patients include global developmental delay (9/10), brain anomalies (6/10), and eye anomalies (7/10). Notably, seizures were predominantly reported in patients with monoallelic variants. Structural modeling of missense variants in PLXNA1 suggests distortion in the native protein. Our zebrafish studies enforce an embryonic role of plxna1a and plxna1b in the development of the central nervous system and the eye. CONCLUSION: We propose that different biallelic and monoallelic variants in PLXNA1 result in a novel neurodevelopmental syndrome mainly comprising developmental delay, brain, and eye anomalies. We hypothesize that biallelic variants in the extracellular Plexin-A1 domains lead to impaired dimerization or lack of receptor molecules, whereas monoallelic variants in the intracellular Plexin-A1 domains might impair downstream signaling through a dominant-negative effect

NUMERICAL INVESTIGATION OF THE ORIGIN OF LOSSES IN THE ROTOR HUB REGION OF A MULTISTAGE AXIAL COMPRESSOR

Endwall losses and secondary air flow are considered to be responsible for a significant part of the flow losses in compressors. Their reduction can be achieved by 3D blade design and non-axisymmetric endwalls. In order to evaluate the potential of both effects, an analysis of secondary air flow and the origin of losses is realized. This paper presents multiple numerical simulations to determine the predominant phenomena at the origin of losses in the hub region of the last rotor of the Rig 250, a 4-stage compressor with cantilevered stators and rotor tip clearances. In a first study (I), an inviscid endwall condition at the hub of rotor 4 has been investigated. This condition strongly reduces the secondary air flow from the pressure side to the suction side and shows a significant reduction of the losses in the hub region. But the typical loss distribution over the blade height with a local maximum between 5 and 15%of the blade height is not changed. Through this study the losses generated by the endwall boundary layer and the resulting secondary air flow are evaluated. Moreover, the potential for endwall contouring and 3D blading in the hub region is estimated, which can be used in future design studies. In the second study (II), ideal radial distributions of the velocity and of the inflow angles at the inlet of the rotor 4 are set. The results show the dependencies between the inflow condition and the loss production in the blade passage near the endwall. These studies sets the theoretical maximal potential for improvement techniques, like endwall contouring or the modification of the upstream stator

Artificial Intelligence und Machine Learning in der Medizin: eine medizinische und rechtliche Würdigung am Beispiel der Radiologie

Gerade in der Radiologie wird der Einsatz von Artificial Intelligence bzw. Machine Learning es ermöglichen, die Arbeitslast der Ärzteschaft zu reduzieren und dadurch z.B. mehr Zeit für komplexere Fälle und für den direkten Patientenkontakt zu ermöglichen. Während sich zumindest die medizinische Forschung bereits intensiv mit dem Machine Learning und dessen Einsatz in der Medizin auseinandersetzt, fehlen weitestgehend äquivalente rechtliche Würdigungen. Es gilt, sich auch aus rechtlicher Perspektive frühzeitig und intensiver mit den damit einhergehenden rechtlichen Herausforderungen auseinanderzusetzen, um den daraus resultierenden Chancen und Gefahren gerecht zu werden

Molecular characterization of HOXA13 polyalanine expansion proteins in hand–foot–genital syndrome How to cite this article: Utsch B, McCabe CD, Galbraith K, Gonzalez R, Born M, DÖtsch J, Ludwig M, Reutter H, Innis JW. 2007. Molecular characterization of HOXA13 polyalanine expansion proteins in hand–foot–genital Syndrome. Am J Med Genet Part A 143A:3161–3168. Boris Utsch and Colleen D. McCabe contributed equally to this work.

We report on a father and daughter with hand–foot–genital syndrome (HFGS) with typical skeletal and genitourinary anomalies due to a 14-residue polyalanine expansion in HOXA13. This is the largest (32 residues) polyalanine tract so far described for any polyalanine mutant protein. Polyalanine expansion results in protein misfolding, cytoplasmic aggregation and degradation; however, HOXA13 polyalanine expansions appear to act as loss of function mutations in contrast to gain of function for HOXD13 polyalanine expansions. To address this paradox we examined the cellular consequences of polyalanine expansions on HOXA13 protein using COS cell transfection and immunocytochemistry. HOXA13 polyalanine expansion proteins form cytoplasmic aggregates, and distribution between cytoplasmic aggregates or the nucleus is polyalanine tract size-dependent. Geldanamycin, an Hsp90 inhibitor, reduces the steady-state abundance of all polyalanine-expanded proteins in transfected cells. We also found that wild-type HOXA13 or HOXD13 proteins are sequestered in HOXA13 polyalanine expansion cytoplasmic aggregates. Thus, the difference between HOXA13 polyalanine expansion loss-of-function and HOXD13 polyalanine expansion dominant-negative effect is not the ability to aggregate wild-type group 13 paralogs but perhaps to variation in activities associated with refolding, aggregation or degradation of the proteins. © 2007 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/57541/1/31967_ftp.pd