Refining analyses of copy number variation identifies specific genes associated with developmental delay.

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Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines

Summary: IgG antibodies are important mediators of vaccine-induced immunity through complement- and Fc receptor-dependent effector functions. Both are influenced by the composition of the conserved N-linked glycan located in the IgG Fc domain. Here, we compared the anti-Spike (S) IgG1 Fc glycosylation profiles in response to mRNA, adenoviral, and protein-based COVID-19 vaccines by mass spectrometry (MS). All vaccines induced a transient increase of antigen-specific IgG1 Fc galactosylation and sialylation. An initial, transient increase of afucosylated IgG was induced by membrane-encoding S protein formulations. A fucose-sensitive ELISA for antigen-specific IgG (FEASI) exploiting FcγRIIIa affinity for afucosylated IgG was used as an orthogonal method to confirm the LC-MS-based afucosylation readout. Our data suggest that vaccine-induced anti-S IgG glycosylation is dynamic, and although variation is seen between different vaccine platforms and individuals, the evolution of glycosylation patterns display marked overlaps

New generation of knowledge: Towards an inter- and transdisciplinary framework for sustainable pathways of palm oil production

The production and expansion of palm oil have emerged as a major and controversial issue in political and public debates in the North and the South on sustainable food and agriculture. Scientific research has played a marginal role in these debates that are characterized by black and white views on palm oil as a good, bad or even ugly crop, and by solutions that are limited in scope. Our first argument is that new conceptualization of the complexity and dynamics of the palm oil sector can revitalize debate on sustainable palm oil and be used to identify sustainable pathways for palm oil production. For this purpose, we develop an interdisciplinary framework, conceptualizing the palm oil sector as consisting of systems, flows and networks. Our second argument is that a transdisciplinary approach is need to identify and develop sustainable pathways. We present six ideas on how to do so. Given the controversy in debates on the production and expansion of palm oil, we consider switchers as critical actors for shaping sustainable pathways, both in the palm oil sector and at the science-policy interface