281 research outputs found
Self-organized current transport through low angle grain boundaries in YBaCuO thin films, studied magnetometrically
The critical current density flowing across low angle grain boundaries in
YBaCuO thin films has been studied magnetometrically.
Films (200 nm thickness) were deposited on SrTiO bicrystal substrates
containing a single [001] tilt boundary, with angles of 2, 3, 5, and 7 degrees,
and the films were patterned into rings. Their magnetic moments were measured
in applied magnetic fields up to 30 kOe at temperatures of 5 - 95 K; current
densities of rings with or without grain boundaries were obtained from a
modified critical state model. For rings containing 5 and 7 degree boundaries,
the magnetic response depends strongly on the field history, which arises in
large part from self-field effects acting on the grain boundary.Comment: 8 pages, including 7 figure
Phase I and pharmacokinetic study of XR11576, an oral topoisomerase I and II inhibitor, administered on days 1–5 of a 3-weekly cycle in patients with advanced solid tumours
XR11576 is an oral topoisomerase I and II inhibitor. The objectives of this phase I study were to assess the dose-limiting toxicities (DLTs), to determine the maximum tolerated dose (MTD) and to describe the pharmacokinetics (PKs) of XR11576 when administered orally on days 1-5 every 3 weeks to patients with advanced solid tumours. Patients were treated with escalating doses of XR11576 at doses ranging from 30
Metabolomic Analysis in Severe Childhood Pneumonia in The Gambia, West Africa: Findings from a Pilot Study
Pneumonia remains the leading cause of death in young children globally and improved diagnostics are needed to better identify cases and reduce case fatality. Metabolomics, a rapidly evolving field aimed at characterizing metabolites in biofluids, has the potential to improve diagnostics in a range of diseases. The objective of this pilot study is to apply metabolomic analysis to childhood pneumonia to explore its potential to improve pneumonia diagnosis in a high-burden setting. and Random Forests (RF). ‘Unsupervised’ (blinded) data were analyzed by Principal Component Analysis (PCA), while ‘supervised’ (unblinded) analysis was by Partial Least Squares-Discriminant Analysis (PLS-DA) and Orthogonal Projection to Latent Structures (OPLS). Potential markers were extracted from S-plots constructed following analysis with OPLS, and markers were chosen based on their contribution to the variation and correlation within the data set. The dataset was additionally analyzed with the machine-learning algorithm RF in order to address issues of model overfitting and markers were selected based on their variable importance ranking. Unsupervised PCA analysis revealed good separation of pneumonia and control groups, with even clearer separation of the groups with PLS-DA and OPLS analysis. Statistically significant differences (p<0.05) between groups were seen with the following metabolites: uric acid, hypoxanthine and glutamic acid were higher in plasma from cases, while L-tryptophan and adenosine-5′-diphosphate (ADP) were lower; uric acid and L-histidine were lower in urine from cases. The key limitation of this study is its small size.Metabolomic analysis clearly distinguished severe pneumonia patients from community controls. The metabolites identified are important for the host response to infection through antioxidant, inflammatory and antimicrobial pathways, and energy metabolism. Larger studies are needed to determine whether these findings are pneumonia-specific and to distinguish organism-specific responses. Metabolomics has considerable potential to improve diagnostics for childhood pneumonia
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Public-private entanglements: consultant use by local planning authorities in England
Despite intermittent recognition of the input of private planning consultants in the UK planning system, there remains a paucity of empirical studies into their roles and influence in contemporary practice. Drawing on interviews with both public and private planners in England, this paper explores the nature of the public-private entanglements that increasingly define local planning practice. These in-clude the heterogeneity of the consultant market, the rationales employed to justify consultant use, the nature of the expertise being deployed, and the asymmetrical nature of public/private relationships. The paper argues that the demands made on the public planning system and the planners that operate it are driving teleological explanations of the use of private expertise, displaying an ambivalence to the fact that Local Planning Authorities are in a position of critical dependency with private sector consultants. In concluding, it is argued that the knowledges that underpin planning practices are increasingly shaped by the market, with the potential to un-dermine planning’s public interest purpose
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