Clozapine's functional mesolimbic selectivity is not duplicated by the addition of anticholinergic action to haloperidol: a brain stimulation study in the rat

This study examined whether the anticholinergic potency of the clinically superior antipsychotic drug clozapine contributes to clozapine's anatomically-selective functional inhibition of the mesolimbic dopamine (DA) system, using an electrical brain-stimulation reward (BSR) paradigm in rats that has been previously shown to be highly sensitive to clozapine's mesolimbic functional selectivity. Rats were chronically administered saline, clozapine, haloperidol, or haloperidol plus the anticholinergic compound trihexyphenidyl, and threshold sensitivity of the mesolimbic and nigrostriatal DA systems was assessed using the BSR paradigm, to infer degree of functional DA blockade produced by the chronic drug regimens. Chronic saline produced no change in either DA system. Congruent with previous findings, chronic clozapine powerfully inhibited the mesolimbic DA system but spared the nigrostriatal DA system. Also congruent with previous findings, chronic haloperidol powerfully inhibited both DA systems. Compared to chronic haloperidol alone, chronic haloperidol plus chronic trihexyphenidyl exerted diminished anti-DA action in both the mesolimbic and nigrostriatal DA systems. These results suggest that clozapine's anticholinergic potency is not an adequate explanation for its functional mesolimbic selectivity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46341/1/213_2005_Article_BF02246960.pd

Imagining violent criminals: an experimental investigation of music stereotypes and character judgments

Objectives: In criminal cases, prosecutors treat defendant-authored rap lyrics as an admission of guilt rather than as art or entertainment. Do negative stereotypes about rap music shape jurors’ attitudes about the defendant, unfairly influencing outcomes? Replicating and extending previous research (Fischoff Journal of Applied Social Psychology, 29(4), 795–805, 1999; Fried Journal of Applied Social Psychology, 26(23), 2135–2146, 1996; Dunbar et al. Public Policy, and Law, 22(3), 280–292, 2016), the current study begins to address these questions. Methods: Using an experimental approach, participants were presented with music lyrics and asked to make judgments about the person who wrote the lyrics. All participants read the same lyrics but were told they were from a country, heavy metal, or rap song, depending upon the condition into which they were randomly assigned. Again using random assignment, participants were provided with information about the race of the songwriter in a photo of a young man. Finally, participants were tasked with judging the character of the songwriter, including traits such as his violent nature and criminal disposition. Results: We find that writers of violent “rap” lyrics are perceived more negatively than writers who pen identical country and heavy metal lyrics. We also find that songwriter race matters; no differences in judgments were detected between the White and Black songwriters; however, when race information was not provided, participants who inferred the songwriter was Black judged him more negatively than participants who inferred he was White. Conclusions: These findings have implications for racial disparities in the criminal justice system