FORMULATION AND IN VITRO EVALUATION OF RAMELTEON TABLETS FOR COLON DRUG DELIVERY SYSTEM BY COMPRESSION COATING

Objective: Ramelteon, is a sleep agent that selectively binds to the MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN), instead of binding to GABAA receptors. In the present research work, the formulation of ramelteon targeted to colon by using various polymers developed. Methods: Colon-targeted tablets were prepared in two steps. Initially, core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethylcellulose, Eudragit RLPO and L100 were used as enteric coating polymers. The precompression blend of all formulations was subjected to various flow property tests and all the formulations were passed the tests. The tablets were coated by using polymers and the coated tablets were subjected to physical characterization, drug content, in vitro drug release and kinetics of drug release. Results: Among all the formulations, F4 formulation was found to be optimized as it was retarded the drug release up to 18 h and showed maximum of 99.25% drug release. It followed the first-order kinetics mechanism. All the formulations having Korsmeyer-Peppas ‘n’ values are in the range of 0.540 to 0.818. Hence, it was concluded that the prepared formulations followed non-Fickian diffusion. Conclusion: An effective and stable remelteon colon targeted formulation developed for treating insomnia

HYDROGELS THE THREE DIMENSIONAL NETWORKS: A REVIEW

Hydrogel products constitute polymeric materials as a group, the hydrophilic structure which renders them the capability of holding large amounts of water in their 3-dimensional networks. Extensive employment of those products during a number of commercial and environmental areas of application is taken into account to be of prime importance. Needless to say, natural hydrogels were gradually replaced by synthetic types thanks to their higher water absorption capacity, long service life, and wide sorts of raw chemical resources. Literature on this subject was found to be expanding, especially within the scientific areas of research. However, variety of technical reports publications and handling hydrogel products from the points of view of engineering were examined to overview technological aspects covering this growing the field of research. the first objective of this text is to review the literature concerning classification of hydrogels on different bases, chemical characteristics and physical characteristics of those products, and technical feasibility of their best utilization. It also involved the technologies adopted for hydrogel production along-side process and design implications, optimized conditions, and the block diagrams of the preparation process. Recent forms of hydrogel material generations are also presented in some details that are innovative in nature

ALKAPTONURIA SYNDROME-A REVIEW

Alkaptonuria, also called endogenous ochronosis, and also called as Black Urine Disease, is a rare metabolic autosomal recessive disorder. It occurs by complete inhibition of homogentisic acid oxidase enzyme having its deposition in various tissues. Alkaptonuria is caused due to deficiency of homogentisic acid oxidase involved in the metabolism of tyrosine. Dark discolouration of urine, ochronosis at cartilage and connective tissues, arthritis at the third of fourth decade of life, renal stone disease, spontaneous tendon rupture etc. May be seen in alkaptonuria. Disease severity varies among individual patients, even between siblings, and increase with age because of homogentisic acid accumulation. Usually, life span is not shortened in AKU, but the quality of life is severely effected. Several studies have suggested that Nitisinone may be effective in the treatment of alkaptonuria. Characteristically, the excess HGA means sufferers pass dark urine, which upon standing turns black. This is a feature present from birth. Over time patients develop other manifestations of AKU, due to the deposition of HGA in collagenous tissues, namely ochronosis and ochronotic osteoarthropathy. Although this condition does not reduce life expectancy, it significantly affects the quality of life. The natural history of this condition is becoming better understood, despite gaps in knowledge. Clinical assessment of the condition has also improved along with the development of potentially disease-modifying therapy. Furthermore, recent developments in AKU research have to lead to new understanding of the disease, and further study of the AKU arthropathy has the potential to influence therapy in the management of osteoarthritis

Issues related to implementation of the forest rights act in Andhra Pradesh

The Scheduled Tribes and Other Traditional Forest Dwellers (Recognition of Forest Rights) Act 2006 has been passed by Parliament to address the injustice done to tribal and adivasi communities and other forest dwellers. It confers legal entitlements on the lands they were cultivating for centuries. This paper looks at various issues with regard to implementation of the Act in the state of Andhra Pradesh. It investigates why the Act emerged in relation to AP. It also reviews the range of forest rights deprivations and how they came about. The authors consider the likely livelihood impact of such a pro-poor institutional reform on the people of the state

Transcriptional changes are tightly coupled to chromatin reorganization during cellular aging

Human life expectancy is constantly increasing and aging has become a major risk factor for many diseases, although the underlying gene regulatory mechanisms are still unclear. Using transcriptomic and chromosomal conformation capture (Hi-C) data from human skin fibroblasts from individuals across different age groups, we identified a tight coupling between the changes in co-regulation and co-localization of genes. We obtained transcription factors, cofactors, and chromatin regulators that could drive the cellular aging process by developing a time-course prize-collecting Steiner tree algorithm. In particular, by combining RNA-Seq data from different age groups and protein-protein interaction data we determined the key transcription regulators and gene regulatory changes at different life stage transitions. We then mapped these transcription regulators to the 3D reorganization of chromatin in young and old skin fibroblasts. Collectively, we identified key transcription regulators whose target genes are spatially rearranged and correlate with changes in their expression, thereby providing potential targets for reverting cellular aging.ISSN:1474-9718ISSN:1474-9728ISSN:1474-972

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Not AvailableTo properly plan loss reduction strategies, information on the magnitude of losses is important. The up-to-date data on harvest and post harvest losses in inland fisheries from different sources are not available in Indian context. The need of such estimates has become all the more important. Hence, a pilot study was undertaken with the objective of assessing the harvest losses at various inland fishery resources in East Godavari, West Godavari and Khammam districts in Andhra Pradesh, India and Hirakud reservoir in Orissa, India. The extent of losses were found to be 2.40 % in freshwater aquaculture, 1.86 % in brackishwater aquaculture, 6.52 to 8.89 % in reservoir fisheries, 3.69 to 4.48 % at landing centres of lake, 8.56 to 13.94 %, in riverine fisheries and 6.32 % in estuarine fisheries. An effort has also been made to identify the causes for these losses, which have been discussed in detail in this paper.Not Availabl