8,011 research outputs found
Nebraska Oil and Gas Update
The following is an update on Nebraska\u27s legislative activity and case law relating to oil and gas and mineral law from August 1, 2011, to July 31, 2012
The Use of Macro-Level Safety Performance Functions for Province-Wide Road Safety Management
Safety Performance Functions (SPFs) play a key role in identifying hotspots. Most SPFs were built at the micro-level, such as for road intersections or segments. On the other hand, in case of regional transportation planning, it may be useful to estimate SPFs at the macro-level (e.g., counties, cities, or towns) to determine ad hoc intervention prioritizations. Hence, the final aim of this study is to develop a predictive framework, supported by macro-level SPFs, to estimate crash frequencies, and consequently possible priority areas for interventions. At a province-wide level. The applicability of macro-level SPFs is investigated and tested thanks to the database retrieved in the context of a province-wide Sustainable Urban Mobility Plan (Bari, Italy). Starting from this database, the macro-areas of analysis were carved out by clustering cities and towns into census macro-zones, highlighting the potential need for safety interventions, according to different safety performance indicators (fatal + injury, fatal, pedestrian and bicycle crashes) and using basic predictors divided into geographic variables and road network-related factors. Safety performance indicators were differentiated into rural and urban, thus obtaining a set of 4 Ă 2 dependent variables. Then they were linked to the dependent variables by means of Negative Binomial (NB) count data models. The results show different trends for the urban and rural contexts. In the urban environment, where crashes are more frequent but less severe according to the available dataset, the increase in both population and area width leads to increasing crashes, while the increase in both road length and mean elevation are generally related to a decrease in crash occurrence. In the rural environment, the increase in population density, which was not considered in the urban context, strongly influences crash occurrence, especially leading to an increase in pedestrian and bicyclist fatal + injury crashes. The increase in the rural network length (excluding freeways) is generally related to a greater number of crashes as well. The application of this framework aims to reveal useful implications for planners and administrators who must select areas of intervention for safety purposes. Two examples of practical applications of this framework, related to safety-based infrastructural planning, are provided in this study
Is idiopathic intracranial hypertension without papilledema a risk factor for migraine progression?
The association of chronic migraine (CM) with an idiopathic intracranial hypertension without papilledema (IIHWOP), although much more prevalent than expected in clinical series of CM sufferers, is not included among the risk factors for migraine progression. We discuss the available evidence supporting the existence of a pathogenetic link between CM and idiopathic intracranial hypertensive disorders and suggest a causative role for IIHWOP in migraine progression
Lithographically and electrically controlled strain effects on anisotropic magnetoresistance in (Ga,Mn)As
It has been demonstrated that magnetocrystalline anisotropies in (Ga,Mn)As
are sensitive to lattice strains as small as 10^-4 and that strain can be
controlled by lattice parameter engineering during growth, through post growth
lithography, and electrically by bonding the (Ga,Mn)As sample to a
piezoelectric transducer. In this work we show that analogous effects are
observed in crystalline components of the anisotropic magnetoresistance (AMR).
Lithographically or electrically induced strain variations can produce
crystalline AMR components which are larger than the crystalline AMR and a
significant fraction of the total AMR of the unprocessed (Ga,Mn)As material. In
these experiments we also observe new higher order terms in the
phenomenological AMR expressions and find that strain variation effects can
play important role in the micromagnetic and magnetotransport characteristics
of (Ga,Mn)As lateral nanoconstrictions.Comment: 11 pages, 4 figures, references fixe
Platelet lysate maintains chondrogenic potential and promotes cartilage regeneration
cartilage.
We
report
the
biological
effect
of
the
platelet
lysate
(PL),
a
PRP
derivative,
on
primary
human
articular
chondrocytes
(HAC)
cultured
under
both
physiological
and
inflammatory
condition.
Added
to
the
culture
medium,
PL
induced
a
strong
mitogenic
response
in
the
chondrocytes.
The
in
vitro
expanded
cell
population
maintained
a
chondrogenic
re-Ââdifferentiation
potential
as
revealed
by
micromass
culture
in
vitro
as
well
as
in
vivo
as
demonstrated
by
ectopic
cartilage
formation
in
nude
mice.
Furthermore,
in
chondrocytes
cultured
in
the
presence
of
the
pro-Ââinflammatory
cytokine
IL-Ââ1α,
the
PL
induced
a
drastic
enhancement
of
the
synthesis
of
the
cytokines
IL-Ââ6
and
IL-Ââ8
and
of
NGAL,
a
lipocalin
expressed
in
cells
of
the
chondrogenic
lineage.
These
events
were
controlled
by
the
p38
MAP
kinase
and
NF-ÂâÎșÎ
pathways.
The
pro-Ââinflammatory
effect
of
the
PL
was
a
transient
phenomenon.
In
fact,
after
an
initial
up
regulation,
we
observed
a
significant
reduction
of
the
NF-ÂâÎșÎ
activity
together
with
the
repression
of
the
inflammatory
enzyme
ciclooxygenase-Ââ2
(COX-Ââ2).
Moreover,
the
medium
of
chondrocytes
cultured
in
the
contemporary
presence
of
PL
and
IL-Ââ1α,
showed
a
significant
enhancement
of
the
chemoattractant
activity
versus
untreated
chondrocytes.
On
the
whole,
our
findings
support
the
concept
that
the
platelet
products
have
a
direct
beneficial
effect
on
articular
chondrocytes
and
at
the
same
time
could
drive
in
sequence
a
trans
The aberrant expression in epithelial cells of the mesenchymal isoform of FGFR2 controls the negative crosstalk between EMT and autophagy
Signalling of the epithelial splicing variant of fibroblast growth factor receptor 2 (FGFR2b) triggers both differentiation and autophagy, while the aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells induces impaired differentiation, inhibition of autophagy as well as the induction of the epithelial-mesenchymal transition (EMT). In light of the widely proposed negative loop linking autophagy and EMT in the early steps of carcinogenesis, here we investigated the possible involvement of FGFR2c aberrant expression and signalling in orchestrating this crosstalk in human keratinocytes. Biochemical, molecular, quantitative immunofluorescence analysis and in vitro invasion assays, coupled to the use of specific substrate inhibitors and transient or stable silencing approaches, showed that AKT/MTOR and PKCΔ are the two hub signalling pathways, downstream FGFR2c, intersecting with each other in the control of both the inhibition of autophagy and the induction of EMT and invasive behaviour. These results indicate that the expression of FGFR2c, possibly resulting from FGFR2 isoform switch, could represent a key upstream event responsible for the establishment of a negative interplay between autophagy and EMT, which contributes to the assessment of a pathological oncogenic profile in epithelial cells
Hemp Biomass Pretreatment and Fermentation with non- Saccharomyces Yeasts: Xylose Valorization to Xylitol
Hemp hurds are the main byproduct from hemp fibers supply chain and they could represent valuable feedstock of lignocellulosic biomass for biorefineries. The industrial hemp variety "Carmagnola", is characterized by low amounts of ash and high amount of carbohydrates. Alpha-cellulose (44% w/w), hemicellulose (25%), and lignin (23%) were fractionated using an organosolv pretreatment. The enzymatic hydrolysis of the cellulose fraction yielded up to 60% of glucose, that can easily find application as substrate for industrial fermentations. On the other hand, the black liquor originating from hemicellulose contains mainly xylose and minor amounts of other sugars. In the perspective of finding an application of black liquor, 50 yeasts belonging to 24 ascomycetous species were screened both in aerobiosis and anaerobiosis for the production of ethanol and the sugar alcohols xylitol and arabitol from xylose. Pichia fermentans WC 1507, Wickerhamomyces anomalus WC 1501, and Kluyveromyces bacillosporus WC 1404 were found to consume xylose, yielding xylitol in aerobic conditions. In particular, aerobic flask cultures of P. fermentans WC 1507 containing 120 g/L xylose showed the highest xylitol production values, yielding 63.5 g/L xylitol with a YP/S of 71.5%. Black liquor, exploited as a carbon source, has been successfully utilized by the three selected yeast strains at a concentration of 20 g/L in the culture medium, resulting in comparable or higher yields of biomass and xylitol compared to the medium containing pure xylose. A higher concentration of black liquor in the culture medium (to reach 120 g/l of xylose) has determined an inhibition of the growth of yeasts indicating the need for treatments for the removal of inhibitors. These preliminary results can be considered promising for the microbial valorization of lignocellulosic hemp feedstock toward the production of xylitol
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