A RETROSPECTIVE STUDY TO EVALUATE THE EFFICACY OF INJECTION AUGMENTIN IN COVID-19 PATIENTS WITH PNEUMONIA AT A TERTIARY CARE TEACHING HOSPITAL, TELANGANA

Objective: Coronavirus is a single-stranded, enveloped, positive-sense RNA virus. It is responsible for the acute respiratory syndrome (SARS) and the disease is named COVID-19 by WHO. It is also called SARS-CoV-2. Pneumonia is one of the complications of COVID-19 disease. Patients with pneumonia admitted to General Hospital were treated with Augmentin. Augmentin is a broad-spectrum antibacterial that has been available for clinical use in a wide range of indications for over 20 y and is now used primarily in the treatment of respiratory tract infections. The main objective of our study is to evaluate the efficacy of Augmentin in COVID-19 patients with pneumonia in terms of beneficial effects after treatment. Methods: The present study was a retrospective, observational, record-based study of the case sheets of COVID-19 patients with pneumonia. The statistical analysis was done using paired t-test. Results: In our institution COVID-19 patients with pneumonia were treated with Tablet FAVIRAPIR and Injection AUGMENTIN. The results were calculated using paired t-test and the P-value was<0.0001, which is significant as it is less than 0.05. Therefore, the post-treatment outcome results showed a significant improvement in disease reduction. Conclusion: The study concludes that the empirical treatment of COVID-19 patients with pneumonia using an appropriate antibiotic reduces further deterioration of patients with pneumonia due to complications and also protects the patients from acquired infections during the hospital stay

A cross-sectional, questionnaire-based study on knowledge, attitude, and practice of pharmacovigilance among post-graduates at a tertiary care teaching hospital, Telangana

Background: Pharmacovigilance is the process of drug safety monitoring that improves patients' quality of life through the collection and analysis of Adverse Drug Reactions (ADRs). In our state, most of the ADRs are reported by a spontaneous reporting system of individual cases from health care professionals to Adverse Drug Reaction Monitoring Centre (AMC) under the Pharmacovigilance Programme of India (PvPI). Post-graduates (PGs) play a vital role in reporting ADRs as they are in personal evidence with all events after drug administration. The main objective of our study is to evaluate the Knowledge, Attitude, and Practice of Pharmacovigilance among post-graduates.Methods: The present study was a cross-sectional questionnaire-based study on knowledge, attitude, and practice (KAP) of Pharmacovigilance among 150 post-graduates at a tertiary care teaching hospital, Telangana. The statistical analysis was done using Statistical Package for Social Sciences (SPSS) version 25 software.Results: The results showed that there is relatively less knowledge among postgraduates. Attitude and practice-based questions evidenced a paradigm shift towards the construction of an organized Pharmacovigilance system. This study also highlights the under-reporting and the interventions needed to improve spontaneous reporting of ADRs.Conclusions: The knowledge of Pharmacovigilance with a positive attitude and practice among post-graduates is essential for reporting ADRs and reducing under-reporting.ng

BIG DATA ANALYTICS IN PHARMACOVIGILANCE - A GLOBAL TREND

Big data analysis has enhanced its demand nowadays in various sectors of health-care including pharmacovigilance. The exact definition of big data is not known to many people though it is routinely used by them. Big data refer to immense and voluminous computerized medical information which are obtained from electronic health records, administrative data, registries related to disease, drug monitoring, etc. This data are usually collected from doctors and pharmacists in a health-care facility. Analysis of big data in pharmacovigilance is useful for early raising of safety alerts, line listing them for signal detection of drugs and vaccines, and also for their validation. The present paper is intended to discuss big data analytics in pharmacovigilance focusing on global prospect and domestic country-India

ASSESSMENT OF KNOWLEDGE, ATTITUDE, AND PRACTICE OF HAEMOVIGILANCE AMONG POST-GRADUATES AT A TERTIARY CARE TEACHING HOSPITAL IN HYDERABAD–A CROSS-SECTIONAL STUDY

Objective: Transfusion of blood and blood products is a life-saving intervention but has the potential to cause adverse events. Haemovigilance is an organized system that includes monitoring, identification, reporting, investigating, and analyzing adverse events related to transfusion and the manufacture of blood products. However, reporting of adverse reactions is markedly less in our country. This study is intended to assess knowledge, attitude, and practice of Haemovigilance among post-graduates (PGs) and to scrutinize various causes of Underreporting. Methods: A cross-sectional pre-validated questionnaire-based study was carried out in Osmania medical college and hospital, Hyderabad over 4 months among 150 PGs. Results: Only120 PGs out of 150, provided their responses. Only 20% of the PGs knew about the Haemovigilance program. 41.6% knew how to report and who can report. 2% knew about Hemo-vigil and Donor vigil software. 100% of PGs show a positive attitude towards transfusion reaction reporting and agreed that Haemovigilance activities should include in the undergraduate curriculum. Medicolegal liability issues, lack of knowledge, and lack of time were the main factors that forbade them from reporting. Conclusion: A positive attitude towards Haemovigilance exists among PGs but knowledge regarding the Haemovigilance program was poor and the practice of transfusion reactions reporting was significantly reduced. Hence, our study suggests the inclusion of the procedure of transfusion reactions reporting in the Undergraduate curriculum and augmentation of CMEs/workshops/seminars to PGs