CARCINOMA FOLLICOLARE DELLA TIROIDE IN BAMBINI, ADOLESCENTI E GIOVANI ADULTI: ASPETTI CLINICI, DIAGNOSTICI, TERAPIA CHIRURGICA E FOLLOW UP.

Il carcinoma follicolare della tiroide è una neoplasia rara nei bambini e in generale in età pediatrica. Oggetto di studio della nostra tesi è la conoscenza del tumore in tutte le sue caratteristiche, morfologiche e cliniche, e di valutare il miglior approccio terapeutico e di follow-up sulla base dei dati clinici in nostro possesso e della letteratura a nostra disposizione

Surgical management of follicular thyroid carcinoma in children and adolescents: A study of 30 cases

Background/Purpose: The purpose of the study is to describe the anatomoclinical, diagnostic, therapeutic and prognostic aspects of pediatric follicular thyroid carcinoma (FTC) in order to choose the best therapeutic strategy. Methods: Our study includes patients ≤ 18 years old surgically treated for FTC in four Italian Pediatric Surgery Centers from January 2000 to March 2017. The collected data were compared with those of 132 patients matched for age with a histological diagnosis of papillary thyroid carcinoma (PTC) surgically treated in the same institutions during the same period and with the data of patients diagnosed with FTC found in the literature; p-values 4 cm, especially with high after-surgery Tg rate, a completion of thyroidectomy is recommended. In patients with multifocal neoplasia, and/or tumor size ≥ 4 cm, and/or extrathyroid extension, and/or lymph node metastasis, and/or distant metastasis, total thyroidectomy followed by radioiodine therapy is generally indicated. Levels of Evidence: II