Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (\u3baw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the Cindex. A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (\u3baw=0.65, IQR 0.53-0.72, p20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72-0.75). Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts

Inflammatory status in older women with and without metabolic syndrome: is there a correlation with risk factors?

Alessandro de Oliveira Silva,1,2 Ramires Alsamir Tibana,1 Margo Gomes Oliveira Karnikowski,3 Silvana Schwerz Funghetto,3 Jonato Prestes1 1Graduation Program in Physical Education and Health, Catholic University of Brasilia, 2Physical Education Department, Universitary Center of Brasilia, 3Ceilandia Faculty, University of Brasilia, Brasilia, Brazil Purpose: To compare the inflammatory status in older women with and without metabolic syndrome (MetS) and to correlate inflammatory parameters, anthropometric measures, metabolic profile, and blood pressure with MetS Z-score. Methods: This cohort transversal study included 129 older women assigned into two groups: with MetS (n = 48; 66.4 ± 4.4 years; 68.1 ± 8.3 kg; 1.51 ± 0.06 m; 29.8 ± 3.9 kg/m2) and without MetS (n = 81; 68.0 ± 5.8 years; 61.0 ± 9.4 kg; 1.53 ± 0.06 m; 26.0 ± 3.9 kg/m2). Body composition was evaluated by dual-energy X-ray absorptiometry (General Electric-GE model 8548 BX1L, year 2005, Lunar DPX type, software Encore 2005; Rommelsdorf, Germany) and cytokines by enzyme-linked immunosorbent assay. Results: There was no difference between the groups regarding age, height, fat mass, glycosylated hemoglobin, total cholesterol, and low-density lipoprotein cholesterol. However, older women with MetS presented higher body mass, body mass index, waist and hip circumference, waist–hip and waist–height ratio, systolic, diastolic, and mean blood pressure, glucose, insulin, homeostasis model assessment of insulin resistance, MetS Z-score, tumor necrosis factor-α, interferon-γ, and lower lean body mass values compared to women without MetS. Moreover, there were correlations between MetS Z-score and body mass (r = 0.20), waist circumference (r = 0.26), waist–hip (r = 0.32) and waist–height ratio (r = 0.24), blood glucose (r = 0.24), insulin (r = 0.24), homeostasis model assessment of insulin resistance (r = 0.32), triglycerides (r = 0.39), tumor necrosis factor-α (r = 0.28), interferon-γ (r = 0.22), and inverse correlation with high-density lipoprotein cholesterol (r = −0.32). MetS Z-score was positively associated with systolic (r = 0.92), diastolic (r = 0.94), and mean blood pressure (r = 0.98). Conclusion: Older women with MetS have higher cytokine levels, anthropometric measures, metabolic profile, and blood pressure. Inflammatory cytokines may help to improve the understanding of the progression status of MetS in older persons. Keywords: metabolic syndrome, cytokines, agin

Frequência de incontinência urinária em mulheres praticantes de crossfit: um estudo transversal

El objetivo de este estudio fue evaluar la frecuencia de incontinencia urinaria (IU) en mujeres que practican crossfit. Se realizó un estudio transversal con mujeres que habían practicado crossfit, como mínimo, durante 6 meses ininterrumpidos, con edades entre 18 y 35 años y una frecuencia de entrenamiento de al menos tres veces por semana. Se aplicaron cuestionarios de evaluación individual que constó de datos sociodemográficos, antropométricos y deportivos, además del International Consultation on Incontinence Questionnaire - Short Form (ICIQ-UI-SF) para identificar la presencia de IU. También se identificaron la frecuencia y cantidad de pérdida de orina y la interferencia de la IU en la calidad de vida (CV) de las mujeres con incontinencia utilizando el ICIQ-IU-SF. Esas mujeres también respondieron a un cuestionario sobre la gravedad de la IU. La muestra total del estudio se compuso de 50 mujeres, de las cuales 10 (20%) tenían IU. La mayoría de las mujeres con incontinencia presentaban IU de gravedad moderada e interferencia mínima en la CV. Además, se observó una asociación entre haber presentado antecedentes de IU y tener IU (RP=5,33; IC95%=1,41 a 20,10). Se concluye que la frecuencia de IU en mujeres que practican crossfit fue del 20%, y que la IU se presentó, en su mayoría, de gravedad moderada y de interferencia mínima en la CV de ellas.The aim of this study was to determine the frequency of urinary incontinence (UI) in women who practice crossfit. This was a cross-sectional study with women aged between 18 and 35 years, who had been practicing crossfit for at least six months without interruption, and at least three times a week. Individual assessment questionnaires were used, composed of sociodemographic, anthropometric and exercise data, as well as the International Consultation on Incontinence Questionnaire - Short Form (ICIQ-UI-SF) to identify the presence of UI. The frequency and amount of urine loss and UI interference in quality of life (QoL) were also identified via ICIQ-IU-SF. These women also responded to a questionnaire about the severity of UI. The total sample of the study was 50 women, of whom 10 (20%) had UI. Most incontinent women had moderate UI and mild interference in QoL. Moreover, we observed an association between having UI history and presenting UI (PR=5.33, 95% CI=1.41 to 20.10). Given the above, we concluded that the frequency of UI in female crossfit athletes was 20%, with UI being mostly of moderate severity and mild interference in QoL.O objetivo deste estudo foi verificar a frequência de Incontinência Urinaria (IU) em mulheres praticantes de Crossfit. Realizou-se um estudo de corte transversal com mulheres que praticavam Crossfit há, pelo menos, 6 meses ininterruptos, com idade entre 18 a 35 anos e frequência de treino de, no mínimo, três vezes por semana. Foram aplicados questionários de avaliação individual compostos por dados sociodemográficas, antropométricos e esportivos, além do International Consultation on Incontinence Questionnaire - Short Form (ICIQ-UI-SF), para identificar a presença de IU. Também por meio do ICIQ-IU-SF foram identificados a frequência e quantidade de perda de urina e interferência da IU na qualidade de vida (QV) das mulheres incontinentes. Essas mulheres também responderam a um questionário acerca da gravidade da IU. A amostra total do estudo foi de 50 mulheres, das quais 10 (20%) apresentaram IU. A maioria das mulheres incontinentes apresentou IU de gravidade moderada e de interferência leve na QV. Ademais, observou-se associação entre ter histórico de IU e apresentar IU (RP=5,33; IC95%=1,41 a 20,10). Diante do exposto, conclui-se que a frequência de IU em mulheres praticantes de Crossfit foi de 20%, sendo a IU, em sua maioria, de gravidade moderada e de leve interferência na QV