Salivary Cortisol and Binge Eating Disorder in Obese Women After Surgery for Morbid Obesity

Contains fulltext : 77127.pdf (publisher's version ) (Closed access)Background Binge eating episodes characterized by loss of control are hypothesized to be accompanied by changes in hypothalamic pituitary adrenal (HPA) axis functioning. Cortisol is an end product of this neuroendocrine stress system. Purpose The aim of this study was to examine the cortisol levels and the awakening cortisol response (ACR) in obese persons showing binge eating after surgery for morbid obesity. Method Sixteen obese women with binge eating disorder (BED) and 18 obese women without BED participated in the study. Means±SD: age 43 ± 15, body mass index 40 ± 8. Salivary cortisol, anthropometric assessments, and the eating disorder examination interview were taken. Results Women with BED showed a significantly lower waist-to-hip ratio and cortisol levels during the day than women without BED, whereas the ACR did not differ. Conclusion Our cross-sectional study in a small sample generates the hypothesis that neuroendocrine regulation differs between obese women with and without BED after obesity surgery. This finding needs replication in future studies that should also examine the causal direction of the observed association

Effects of cigarette smoking on endurance performance levels of 16- to 19-year-old males

The purpose of this study was to explore the effects of cigarette smoking on the levels of endurance performance in teenagers. Longitudinal data of physical characteristics, smoking habits, exercise habits, and time records in both 1500-meter run and 10-kilometer run of 202 sixteen-to-nineteen-year-old male students were retrieved and analyzed retrospectively. The results showed that the performance levels of exercise-neversmokers in the 1500-meter run did improve as the subjects grew older, and that over the same period, the exercise-smokers did not improve but were able only to maintain their performance levels. The results of two way analysis of variance(ANOVA) indicated that smoking negatively and independently impacts how eighteen and nineteen-year-olds will perform in a 10-kilometer run. The reduced levels of endurance performance in the non-exercise smokers showed up in their results in the 10-kilometer run, and the diminished performance levels of the exercise-smokers were revealed in their 1500-meter run times. These results suggest that smokers obtain less benefits from training than non-smokers, and that we need to assess endurance performance levels among the young by paying careful attention to their smoking habits

Haploinsufficiency of the SERPINA6 gene is associated with severe muscle fatigue: a de novo mutation in corticosteroid-binding globulin deficiency

Corticosteroid-binding globulin (SERPINA6) deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. Here, we present a patient with severe muscle fatigue, normal blood pressure, and abnormal high saliva cortisol levels following a standardized stress test. This patient was found heterozygous for a de novo 367 asparagine-encoding variant of the corticosteroid-binding globulin gene, previously described as "transcortin Lyon". Both parents were homozygous for the ("wildtype") 367 aspartate-encoding allele. To the best of our knowledge, this case represents the first de novo mutation reported for corticosteroid-binding globulin deficiency, implicating a pathogenic role of variants of SERPINA6 in some cases of muscle fatigue