Biochemical Changes in the Niche Following Tumor Cell Invasion

Metastatic cancer is the leading cause of all cancer related deaths. Prostate cancer (PCa) metastasizes preferentially to the bone marrow, specifically within the endosteal niche. Endosteal cells secrete homing molecules that may recruit PCa cells to the bone marrow. Once there, the biochemical signature of this niche regulates PCa fate including cellular dormancy or cell cycle arrest, reactivation and resistance to chemotherapeutics. Growth factors, interleukins, adhesion molecules, as well as extra‐cellular matrix proteins can collectively change the phenotype of PCa cells. Understanding the biochemical signature of endosteal niche parasitism by PCa is imperative for the establishment of new and innovative therapeutic strategies. This review seeks to summarize these important niche signatures and the potential therapeutic approaches to target metastatic PCa within the bone marrow hematopoietic stem cell (HSC) niche. J. Cell. Biochem. 118: 1956–1964, 2017. © 2016 Wiley Periodicals, Inc.Molecular interactions of PCa cells in the bone marrow microenvironment.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137340/1/jcb25843_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137340/2/jcb25843.pd

The role of hematopoietic stem cell niche in prostate cancer bone metastasis

Approximately 80% of prostate cancers exhibit some degree of bone metastasis. The role of the bone marrow and the hematopoietic stem cell (HSC) niche in attracting metastatic cells and maintaining dormancy of disseminated tumor cells (DTCs) is an increasingly important topic towards the development of novel prostate cancer therapies. This paper reviews aspects of the HSC niche that lead to prostate cancer cell homing and dormancy in the bone marrow. This review also discusses the role of DTCs in the niche environment and discusses the role of erythropoietin in targeting DTCs within the HSC niche

Cells Of The Osteoclast Lineage As Mediators Of The Anabolic Actions Of Parathyroid Hormone In Bone

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Protein Extracts of Dentin Affect Proliferation and Differentiation of Osteoprogenitor Cells In Vitro

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141818/1/jper1247.pd