5 research outputs found
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
- Abraham R.
- Adams H.
- Adams P.M.
- Adarmes-GĂłmez A.
- Adarmes-GĂłmez A.D.
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Ahmad S.
- Akinyemi R.O.
- Al-Chalabi A.
- AlarcĂłn-MartĂn Emilio
- Albert M.S.
- Albin R.L.
- Alcolea Daniel
- Alegret Montserrat
- Ali M.
- Allen M.
- Allende I.R.
- Alonso M.D.
- Alonso M.D.
- Alvarez I.
- Alvarez L.
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- Amouyel Philippe
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Get PDFCharacterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
Synthesis and Evaluation of Herbal Based Hair Dye
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- Yogendra Pal
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No full textCardiac and Pericardial Tumors
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- Field of study
No full textAbstracts of National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020
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- A Chakraborty
- A K Bandhyopadhyay
- A K Halder
- A L S Brahma Reddy
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- Abhishek Kumar Jha
- Abhishek Upadhyay
- Adil Wazeer
- Adirae Dinesh
- Adithya Garimella
- Adithyan Annamalai
- Aditi Manikpuri
- Advaita Ghosh
- Ajay Kumar MST
- Ajit Behera
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- Akash Satla
- Akshit Samadhiya
- Akshit Samadhiya
- Alok kumar Ansu
- Aman kumar
- Amaresh Kumar
- Ambar Choubey
- Ambrish Singh
- Ambuj Kumar
- Amit Kr. Singh
- Amit Kumar Kundu
- Amit Kumar Kundu
- Amit Malakar
- Amitava Mandal
- Amitesh Kumar
- Anil Govekar
- Anil Kumar Patra
- Anirban Das
- Anjana Deva
- Ankit Jain
- Ankit Jain
- Ankita Mitra
- Ankita Singh
- Antarjyami Giri
- Anup Kumar
- Anup Kumar
- Apeksha Sharma
- APV Appa Rao
- Arati Lale
- Arindam Dhar
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- Avanish Chandan
- Avanish K Chandana
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- Shashi B. Prasad
- Shashi Bhushan Prasad
- Shashikant Rajpal
- Shashikant Rajpal
- Shazee Rahmani
- Shitanshu Shekhar Chakraborty
- Shiv B Singh
- Shrikant Vidya
- Shrikrushna Bhosale
- Shubham Sharma
- Shubhayan Mukherjee
- Shujaul Hasan
- ShwatiSudha
- Shyam Sunder Sharma
- Siddharth Jeet
- Sikta Panda
- Siuli Dutta
- Siva Prasad racharla
- Sivasankara Reddy
- Smanyu Sawhney
- Snehangshu Roy
- Soma Vivekananda
- Somnath Kumar
- Somnath Kumar
- Sonal Rattan
- Soubhik Kumar Bhaumik
- Soumitra Tarafder
- Soumya
- Soumyajit Das
- Srikanth Salyan
- Srilali Siragam
- Srinivasarao Nathani
- Sriparna Das
- Subhakanta Nayak
- Subhash jadhav
- Subodh Patel
- Subrata Chatterjee
- Subrata Kumar Ghosh
- Sudarsan Ghosh
- Sudhanshu Shekhar pati
- Sudhir Kumar Ghosh
- Sufian Raja
- Sujith Bobba
- Sukhomay Pal
- Suman Mukhopadhyay
- Suman Sadhu
- Sumanta Mukherjee
- Surajit Sinha
- Surendra Kumar Lader
- Suresh Babu G
- Suresh Kumar
- Suresh Kumar
- Surjya K Pal
- Surya Narayan Panda
- Susanta Kumar Sahoo
- Sushant Kumar Pradhan
- Sushant Patil
- Swagataa Dutta
- Swarup Bag
- Swarup Bag
- Swedha N
- Swetha N
- T Venugopal
- T. Anand
- T. Muthumanickam
- T. Raghavendra
- T. Ram Prabhu
- T. Sheela
- Tapas Kumar Bandyopadhyay
- Tavneet Kaur
- Tej Pratap
- Trilok Chauhan
- Tushar Banerjee
- U K Mondal
- UC Jha
- Uday Shanker Dixit
- Udit Kumar
- V C Srivastava
- V Ranjith Kumar
- V. Rajinikanth
- V. Tejaswini
- V.C. Srivastava
- V.Venkatesh
- Vaibhav Gaur
- Vaishnavi Lakheri
- Vandana B. Parmar
- Vandana Kumari Jha
- Vikas Kumar Choubey
- Vikash Kumar
- VikashKumar
- Vikram Kumar S. Jain
- Vinod Kumar
- Vinod Kumar
- Viranshu Kumar
- Vishaldatt Kohir
- Vivek Kumar
- Vrushali P. Hingane
- VSM Ramakrishna R
- Y. Harold Robinson
- Y.N.V. Sai Ram
- Yash Khandelwal
- Yash Khaturia
- Yelamarthy Sai Nishanth
- YNV Sai Ram
- Publication venue
- AIJR Books
- Publication date
- 06/02/2021
- Field of study
No full textThis book presents the abstracts of the papers presented to the Online National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020 (RDMPMC-2020) held on 26th and 27th August 2020 organized by the Department of Metallurgical and Materials Science in Association with the Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, India.
Conference Title: National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020Conference Acronym: RDMPMC-2020Conference Date: 26â27 August 2020Conference Location:Â Online (Virtual Mode)Conference Organizer: Department of Metallurgical and Materials Engineering, National Institute of Technology JamshedpurCo-organizer: Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, IndiaConference Sponsor: TEQIP-
New insights into the genetic etiology of Alzheimerâs disease and related dementias
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
No full textCharacterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele. © 2022, The Author(s)
