9 research outputs found
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
- Abraham R.
- Adams H.
- Adams P.M.
- Adarmes-GĂłmez A.
- Adarmes-GĂłmez A.D.
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Ahmad S.
- Akinyemi R.O.
- Al-Chalabi A.
- AlarcĂłn-MartĂn Emilio
- Albert M.S.
- Albin R.L.
- Alcolea Daniel
- Alegret Montserrat
- Ali M.
- Allen M.
- Allende I.R.
- Alonso M.D.
- Alonso M.D.
- Alvarez I.
- Alvarez L.
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- Amouyel Philippe
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Get PDFCharacterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
The effect of chemical composition on microstructure and properties of intercritically reheated coarse-grained heat-affected zone in X70 steels
- Author
- Publication venue
- 'Sociological Research Online'
- Publication date
- 01/01/2013
- Field of study
Get PDFThe current study investigates the effect of different levels of Ti, N, and Ti/N ratios on microstructure and properties in the intercritically reheated coarse-grained heat-affected zone (ICCGHAZ) of two-pass submerged arc welds in API 5L grade X70 pipe. Gleeble simulation was employed to reproduce the ICCGHAZ of actual welds. Hardness and Charpy V-notch (CVN) tests were performed on the simulated samples. The microstructure of simulated ICCGHAZ was characterized by optical microscopy and scanning electron microscopy (SEM). LePera color etching technique was employed to identify and quantify the martensitic-austenitic (M-A) constituent. Results show that the simulated ICCGHAZ exhibited extremely low toughness, but in the studied range of Ti and N, there was no correlation with Ti/N ratio. The beneficial effect of near-stoichiometric Ti/N ratio observed in coarse-grained heat-affected zone (CGHAZ) did not translate to ICCGHAZ. This was because of the negative effect of the blocky M-A constituent formed on prior austenite grain boundaries
New perspectives on basic mechanisms in lung disease. 4. Why are the airways so vascular?
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- Alsberge M.
- Alving K.
- Anderson S.D.
- Anggard A.
- Baile E.M.
- Baile E.M.
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- Charan N.B.
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- Hill P.
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- Laitinen A.
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- Persson C.G.
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- Sahin G.
- Sahin G.
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- Salonen R.O.
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- Solway J.
- Syabbalo N.C.
- Uddman R.
- Umeno E.
- Webber S.E.
- Webber S.E.
- Webber S.E.
- Welsh M.J.
- Widdicombe J.G.
- Publication venue
- 'BMJ'
- Publication date
- Field of study
No full textTherapeutic Effect of Gypenoside on Chronic Liver Injury and Fibrosis Induced by CCl
- Author
- Publication venue
- 'World Scientific Pub Co Pte Lt'
- Publication date
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No full textThe Effect of Chemical Composition on Microstructure and Properties of Intercritically Reheated Coarse-Grained Heat-Affected Zone in X70 Steels
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textBusiness failure prediction: A comparison of classification methods
- Author
- A.I. Dimitras
- A.I. Dimitras
- A.I. Dimitras
- A.S. Vranas
- B. Efron
- B. Efron
- C. Zopounidis
- C. Zopounidis
- C. Zopounidis
- C. Zopounidis
- C. Zopounidis
- C. Zopounidis
- C. Zopounidis
- C.V. Zavgren
- Constantin Zopounidis
- E. Jacquet-LagrĂšze
- E.I. Altman
- E.I. Altman
- E.I. Altman
- E.K. Laitinen
- H. Frydman
- J.A. Ohlson
- J.E. Boritz
- K. Keasey
- K. Keasey
- M. Luoma
- Michael Doumpos
- P. Theodossiou
- R. Slowinski
- R.L. Keeney
- R.O. Duda
- R.W. Scapens
- W. Gochet
- W.F. Messier
- W.H. Beaver
- Y.P. Gupta
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
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No full textProgressive myoclonic epilepsy due to Gaucher's disease in an adult.
- Author
- Bird A.
- Brady R.O.
- Chang-lo M.
- Davison C.
- de Vries E.
- Diezel P.B.
- Diezel P.B.
- Frederickson D.S.
- Glasgow D.G.
- Haddenbrock S.
- Halliday A.M.
- Halliday A.M.
- Harriman D.G.F.
- Herrlin K. M.
- Hillborg P. 0
- Hodskins M.B.
- Hunt J.R.
- J O King
- Klinken-Rasmussen L.
- Lafora G.R.
- Laitinen L.
- Liebers M.
- Lundborg H.
- Lundborg H.
- Maloney A.F.J.
- Marchand L.
- Marinesco G.
- Matthews W.B.
- Meyer A.
- Miller J.D.
- Morgans M.F.
- Morrison A.N.
- Okada S.
- Pallis C.A.
- Seitelberger F.
- Sjogren T.
- Teilum G.
- Unverricht H.
- Unverricht H.
- van Bogaert L.
- Yokoi S.
- Zeman W.
- Publication venue
- 'BMJ'
- Publication date
- Field of study
No full textPreclinical Data of Eluting Stents
- Author
- A. Carter
- A. Farb
- A. Farb
- A. Farb
- A. Farb
- A. Hartmann
- A. Lafont
- A.F. Wahl
- A.J. Carter
- A.K. Khanna
- A.M. Lincoff
- A.W. Clowes
- A.W. Heldman
- B. Chandrasekar
- B. Chandrasekar
- B. Kantor
- B. Scheller
- B. Scheller
- B.D. Klugherz
- B.E. Bierer
- C. Bauters
- C. Herdeg
- C.D. Rogers
- C.E. Lin
- C.M. Dollery
- D.E. Drachman
- D.H. Walter
- D.I. Axel
- D.M. Whelan
- D.P. Faxon
- D.P. Faxon
- D.R. Holmes Jr
- D.W. Muller
- D.W. Muller
- E. Belle Van
- E. Grube
- E. Grube
- F. Alfonso
- F.J. Dumont
- G. New
- G. Sangiorgi
- G.D. Curfman
- G.I. Kirchner
- H.C. Lowe
- H.S. Kim
- I. Ott
- I. Scheerder De
- I.K. Scheerder De
- J. Aoki
- J. Fajader
- J.E. Kay
- J.E. Mogford
- J.E. Rectenwald
- J.E. Sousa
- J.H. OâKeefe Jr
- J.J. Wentzel
- J.J. Wentzel
- J.J. Wentzel
- J.M. Isner
- K.L. Donaldson
- K.M. Southgate
- L. Buellesfeld
- L. Digue
- M. Kuzuya
- M. Laitinen
- M. Lee
- M. Poon
- M. Poon
- M. Wani
- M.C. Morice
- M.D. Denton
- M.H. Cooper
- M.N. Babapulle
- M.N. Babapulle
- M.P. Bendeck
- M.P. Bendeck
- N.N. Kipshidze
- P. Cirillo
- P. Giannakakou
- P.B. Schiff
- P.B. Schiff
- P.M. Kimball
- R. Fox
- R. Hoffmann
- R. Komatsu
- R. Kornowski
- R. Virmani
- R. Virmani
- R.A. Costa
- R.C. Braun-Dullaeus
- R.O. Hynes
- R.S. Schwartz
- R.S. Schwartz
- S. Oparil
- S.G. Carlier
- S.J. Sollott
- S.O. Marx
- S.P. Karas
- T. Asahara
- T. Decker
- T. Honda
- T. Kakuta
- T. Schachner
- T. Shirota
- T. Shirota
- T. Suzuki
- V. Lindner
- W.G. Morice
- W.J. Giessen van der
- W.Y. Almawi
- Y. Shi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study
No full textNew insights into the genetic etiology of Alzheimerâs disease and related dementias
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
No full textCharacterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele. © 2022, The Author(s)
