44 research outputs found

    АвтоматичСская оптимизация тСхнологичСского комплСкса обогащСния ΠΆΠ΅Π»Π΅Π·Π½Ρ‹Ρ… Ρ€ΡƒΠ΄ ΠΏΠΎ сигналам ΠΌΠ°Π³Π½ΠΈΡ‚Π½ΠΎΠΉ ΠΈΠ½Π΄ΡƒΠΊΡ†ΠΈΠΈ сСпаратора

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    Recombinant antibodies can be used to diagnose, treat and prevent disease by exploiting their specific antigen-binding activities. A large number of drugs currently in development are recombinant antibodies and most of these are produced in cultured rodent cells. Although such cells produce authentic functional products, they are expensive, difficult to scale-up and may contain human pathogens. Plants represent a cost-effective, convenient and safe alternative production system and are slowly gaining acceptance. Five plant-derived therapeutic recombinant antibodies (plantibodies) are undergoing clinical evaluation, three of which can be used as prophylactics

    Π‘ΠΎΠ·Π΄Π°Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠ΅Ρ€Π½Ρ‹Ρ… ΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡ†ΠΈΠΎΠ½Π½Ρ‹Ρ… ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»ΠΎΠ² с Π½Π΅ΠΏΡ€Π΅Ρ€Ρ‹Π²Π½Ρ‹ΠΌ Π°Ρ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π°Ρ€Π°ΠΌΠΈΠ΄Π½Ρ‹ΠΌ Π²ΠΎΠ»ΠΎΠΊΠ½ΠΎΠΌ для примСнСния Π² Π°Π΄Π΄ΠΈΡ‚ΠΈΠ²Π½Ρ‹Ρ… тСхнологиях

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    Π’ Π΄Π°Π½Π½ΠΎΠΉ Ρ€Π°Π±ΠΎΡ‚Π΅ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΎ исслСдованиС создания ΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡ†ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Π° Π½Π° ΠΏΠΎΠ»ΠΈΠΌΠ΅Ρ€Π½ΠΎΠΉ основС с Π½Π΅ΠΏΡ€Π΅Ρ€Ρ‹Π²Π½Ρ‹ΠΌ Π°Ρ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π°Ρ€Π°ΠΌΠΈΠ΄Π½ΠΎΠ³ΠΎ Π²ΠΎΠ»ΠΎΠΊΠ½Π° для примСнСния Π² Π°Π΄Π΄ΠΈΡ‚ΠΈΠ²Π½Ρ‹Ρ… тСхнологиях. ΠžΠΏΠΈΡΠ°Π½Ρ‹ тСхнологичСскиС особСнности процСсса ΠΌΠΎΠ΄ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ повСрхности Π°Ρ€Π°ΠΌΠΈΠ΄Π½ΠΎΠ³ΠΎ Π²ΠΎΠ»ΠΎΠΊΠ½Π°. ИсслСдовано влияниС ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Π° ΠΌΠΎΠ΄ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ повСрхности Π½Π° Π°Π΄Π³Π΅Π·ΠΈΠΎΠ½Π½Ρ‹Π΅ свойства ΠΏΠΎΠ»ΡƒΡ‡Π°Π΅ΠΌΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡ†ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Π°

    Π†Π½Ρ„ΠΎΡ€ΠΌΠ°Ρ†Ρ–ΠΉΠ½Π΅ законодавство. ΠžΡΠ½ΠΎΠ²Π½Ρ– Π½ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠ²Π½Ρ– Π°ΠΊΡ‚ΠΈ

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    НавСдСно основні Π½ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠ²Π½Ρ– Π°ΠΊΡ‚ΠΈ Π· Ρ€Π΅Π³ΡƒΠ»ΡŽΠ²Π°Π½Π½Ρ Ρ–Π½Ρ„ΠΎΡ€ΠΌΠ°Ρ†Ρ–ΠΉΠ½ΠΈΡ… відносин, Π·ΠΎΠΊΡ€Π΅ΠΌΠ°, Ρƒ сфСрі Ρ–Π½Ρ„ΠΎΡ€ΠΌΠ°Ρ†Ρ–Ρ—, Ρ–Π½Ρ„ΠΎΡ€ΠΌΠ°Ρ†Ρ–ΠΉΠ½ΠΈΡ… агСнтств, Ρ‚Π΅Π»Π΅ΠΊΠΎΠΌΡƒΠ½Ρ–ΠΊΠ°Ρ†Ρ–Ρ—, радіочастотного рСсурсу Π£ΠΊΡ€Π°Ρ—Π½ΠΈ, Ρ–Π½Ρ„ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠ·Π°Ρ†Ρ–Ρ—, тСлСбачСння Ρ‚ΠΎΡ‰ΠΎ. Π ΠΎΠ·Ρ€Π°Ρ…ΠΎΠ²Π°Π½ΠΎ Π½Π° студСнтів, які Π·Π΄ΠΎΠ±ΡƒΠ²Π°ΡŽΡ‚ΡŒ Π²ΠΈΡ‰Ρƒ освіту Π² галузях знань "ΠŸΡ€Π°Π²ΠΎ", "Π†Π½Ρ„ΠΎΡ€ΠΌΠ°Ρ†Ρ–ΠΉΠ½Π° Π±Π΅Π·ΠΏΠ΅ΠΊΠ°", "Комп'ΡŽΡ‚Π΅Ρ€Π½Ρ– Π½Π°ΡƒΠΊΠΈ", "Π’Π΅Π»Π΅ΠΊΠΎΠΌΡƒΠ½Ρ–ΠΊΠ°Ρ†Ρ–Ρ—"

    Π Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° матСматичСской ΠΌΠΎΠ΄Π΅Π»ΠΈ процСсса гидроочистки Π²Π°ΠΊΡƒΡƒΠΌΠ½ΠΎΠ³ΠΎ дистиллята

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    Plants are now gaining widespread acceptance as a general platform for the large-scale production of recombinant proteins. The first plant-derived recombinant pharmaceutical proteins are reaching the final stages of clinical evaluation, and many more are in the development pipeline. Over the past two years, there have been some notable technological advances in this flourishing area of applied biotechnology, as shown by the continuing commercial development of novel plant-based expression platforms. There has also been significant success in tackling some of the limitations of plant bioreactors, such as low yields and inconsistent product quality, that have limited the approval of plant-derived pharmaceuticals

    Formation classification based on the well logs data with the use of machine learning

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    Plant-derived pharmaceuticals are poised to become the next major commercial development in biotechnology. The advantages they offer in terms of production scale and economy, product safety, ease of storage and distribution cannot be matched by any current commercial system; they also provide the most promising opportunity to supply low-cost drugs and vaccines to the developing world. However, despite the promised benefits, the commercialization of plant-derived pharmaceutical products is overshadowed by the uncertain regulatory terrain, particularly with regard to the adaptation of good manufacturing practice regulations to field-grown plants. The success of such products also depends on careful negotiation of the intellectual property landscape, particularly the achievement of freedom-to-operate licenses for use in developing countries

    A mechanism for morphogen-controlled domain growth

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    Many developmental systems are organised via the action of graded distributions of morphogens. In the Drosophila wing disc, for example, recent experimental evidence has shown that graded expression of the morphogen Dpp controls cell proliferation and hence disc growth. Our goal is to explore a simple model for regulation of wing growth via the Dpp gradient: we use a system of reaction-diffusion equations to model the dynamics of Dpp and its receptor Tkv, with advection arising as a result of the flow generated by cell proliferation. We analyse the model both numerically and analytically, showing that uniform domain growth across the disc produces an exponentially growing wing disc

    Expression and regulation of neuron-specific enolase

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    SIGLEAvailable from British Library Document Supply Centre-DSC:DXN005871 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

    Control of Gene Expression, Regulation of Transcripion

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    The utility of any transgenic plant is ultimately dependent upon the robust control of transgene expression. In this chapter we examine how various endogenous systems that control gene expression in the host genome can lead to transgene silencing. We then explore approaches to mitigate these effects and particularly focus on the benefits offered by chloroplast transformation
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