16 research outputs found
Time dependence of triplet-singlet excitation transfer from compact poly rA to bound dye at 77 K
Influence of the architecture of light-harvesting antennae on the energy transfer efficiency and rate: Probability analysis
The efficacy of antidepressant medication and interpersonal psychotherapy for adult acute-phase depression: Study protocol of a systematic review and meta-analysis of individual participant data
Background: Antidepressant medication and interpersonal psychotherapy (IPT) are both recommended interventions in depression treatment guidelines based on literature reviews and meta-analyses. However, 'conventional' meta-analyses comparing their efficacy are limited by their reliance on reported study-level information and a narrow focus on depression outcome measures assessed at treatment completion. Individual participant data (IPD) meta-analysis, considered the gold standard in evidence synthesis, can improve the quality of the analyses when compared with conventional meta-analysis. Aims: We describe the protocol for a systematic review and IPD meta-analysis comparing the efficacy of antidepressants and IPT for adult acute-phase depression across a range of outcome measures, including depressive symptom severity as well as functioning and well-being, at both post-treatment and follow-up (PROSPERO: CRD42020219891). Method: We will conduct a systematic literature search in PubMed, PsycINFO, Embase and the Cochrane Library to identify randomised clinical trials comparing antidepressants and IPT in the acute-phase treatment of adults with depression. We will invite the authors of these studies to share the participant-level data of their trials. One-stage IPD meta-analyses will be conducted using mixed-effects models to assess treatment effects at post-treatment and follow-up for all outcome measures that are assessed in at least two studies. Conclusions: This will be the first IPD meta-analysis examining antidepressants versus IPT efficacy. This study has the potential to enhance our knowledge of depression treatment by comparing the short- and long-term effects of two widely used interventions across a range of outcome measures using state-of-the-art statistical techniques
The efficacy of antidepressant medication and interpersonal psychotherapy for adult acute-phase depression: Study protocol of a systematic review and meta-analysis of individual participant data
Contains fulltext :
230571.pdf (publisher's version ) (Open Access)Background: Antidepressant medication and interpersonal psychotherapy (IPT) are both recommended interventions in depression treatment guidelines based on literature reviews and meta-analyses. However, 'conventional' meta-analyses comparing their efficacy are limited by their reliance on reported study-level information and a narrow focus on depression outcome measures assessed at treatment completion. Individual participant data (IPD) meta-analysis, considered the gold standard in evidence synthesis, can improve the quality of the analyses when compared with conventional meta-analysis. Aims: We describe the protocol for a systematic review and IPD meta-analysis comparing the efficacy of antidepressants and IPT for adult acute-phase depression across a range of outcome measures, including depressive symptom severity as well as functioning and well-being, at both post-treatment and follow-up (PROSPERO: CRD42020219891). Method: We will conduct a systematic literature search in PubMed, PsycINFO, Embase and the Cochrane Library to identify randomised clinical trials comparing antidepressants and IPT in the acute-phase treatment of adults with depression. We will invite the authors of these studies to share the participant-level data of their trials. One-stage IPD meta-analyses will be conducted using mixed-effects models to assess treatment effects at post-treatment and follow-up for all outcome measures that are assessed in at least two studies. Conclusions: This will be the first IPD meta-analysis examining antidepressants versus IPT efficacy. This study has the potential to enhance our knowledge of depression treatment by comparing the short- and long-term effects of two widely used interventions across a range of outcome measures using state-of-the-art statistical techniques.6 p
Saccharomyces cerevisiae strains AWRI 838, Lalvin EC1118 and Maurivin PDM do not produce excessive sulfur dioxide in white wine fermentations
Enhanced Binding and Degradation of the C1q Subcomponent of Complement by Thioglycollate-Stimulated Guinea Pig Peritoneal Macrophages
An Overall Aspect of Electroless Ni-P Depositions—A Review Article
Literature on electroless Ni-P deposition, in recent decades, has dwelled primarily on surface
engineering and corrosion-resistant applications. By contrast, we have many research articles devoted
to the engineering aspects of the electroless Ni-P depositions and their technology. The present article
deals with the development of electroless Ni-P bath, advantages and mechanisms of deposition, and
applications of the Ni-P deposits. We also present a comparison of the properties of electroless Ni-P
and Ni-B as well as the recent developments in nickel-phosphorous research. We attempt to review
these in a detailed manner. We also briefly discuss the future developments of electroless Ni-P