36 research outputs found

    History of clinical transplantation

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    How transplantation came to be a clinical discipline can be pieced together by perusing two volumes of reminiscences collected by Paul I. Terasaki in 1991-1992 from many of the persons who were directly involved. One volume was devoted to the discovery of the major histocompatibility complex (MHC), with particular reference to the human leukocyte antigens (HLAs) that are widely used today for tissue matching.1 The other focused on milestones in the development of clinical transplantation.2 All the contributions described in both volumes can be traced back in one way or other to the demonstration in the mid-1940s by Peter Brian Medawar that the rejection of allografts is an immunological phenomenon.3,4 © 2008 Springer New York

    Prevalence of antibodies to bovine paratuberculosis detected by a LAM-ELISA in Costa Rica

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    In Costa Rica the diagnosis of Johne's disease has been based on clinical, histopathological and bacteriological evidence and cutaneous testing; however, the prevalence of the disease at the national level is unknown. Since serum ELISA is a well accepted method of testing for antibody response to Mparatuberculosis (Collins and others 1991, Sockett and others 1992), a bovine serum bank collected in 1990 and a lipoarabinomannan antigen ELISA (LAM-ELISA) which included a preabsorption step with Mycobacteriumphlei (Sudgen and others 1987, 1989) was used.En Costa Rica el diagnóstico de la enfermedad de Johne se ha basado en pruebas clínicas, histopatológicas, bacteriológicas y pruebas cutáneas; sin embargo, se desconoce la prevalencia de la enfermedad a nivel nacional es desconocida. Dado que el ELISA en suero es un método bien aceptado de anticuerpos contra la Mparatuberculosis (Collins y otros, 1991). (Collins y otros 1991, Sockett y otros 1992), un banco de suero bovino suero bovino recogido en 1990 y un antígeno lipoarabinomanano ELISA (LAM-ELISA) que incluía un paso de preabsorción con Mycobacteriumphlei (Sudgen y otros 1987, 1989).Universidad Nacional, Costa RicaEscuela de Medicina Veterinari
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