56 research outputs found
Extraction of the coupling constant from NN scattering data
We reexamine Chew's method for extracting the coupling constant from
np differential cross section measurements. Values for this coupling are
extracted below 350 MeV, in the potential model region, and up to 1 GeV. The
analyses to 1~GeV have utilized 55 data sets. We compare these results to those
obtained via mapping techniques. We find that these two methods give
consistent results which are in agreement with previous Nijmegen
determinations.Comment: 12 pages of text plus 2 figures. Revtex file and postscript figures
available via anonymous FTP at ftp://clsaid.phys.vt.edu/pub/n
On the SigmaN cusp in the pp -> pK+Lambda reaction
Measurements of the reaction at = 2.28 GeV have
been carried out at COSY-TOF. In addition to the FSI and
resonance excitation effects a pronounced narrow structure is observed in the
Dalitz plot and in its projection on the -invariant mass. The
structure appears at the N threshold and is interpreted as
N cusp effect. The observed width of 20 MeV/ is substantially
broader than anticipated from previous inclusive measurements. Angular
distributions of this cusp structure are shown to be dissimilar to those in the
residual channel, but similar to those observed in the
channel
Genetic predisposition to ductal carcinoma in situ of the breast
Background: Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to what extent these two forms of cancer share low-risk susceptibility loci, or whether there are differences in the strength of association for shared loci. Methods: To identify genetic polymorphisms that predispose to DCIS, we pooled data from 38 studies comprising 5,067 cases of DCIS, 24,584 cases of IDC and 37,467 controls, all genotyped using the iCOGS chip. Results: Most (67 %) of the 76 known breast cancer predisposition loci showed an association with DCIS in the same direction as previously reported for invasive breast cancer. Case-only analysis showed no evidence for differences between associations for IDC and DCIS after considering multiple testing. Analysis by estrogen receptor (ER) status confirmed that loci associated with ER positive IDC were also associated with ER positive DCIS. Analysis of DCIS by grade suggested that two independent SNPs at 11q13.3 near CCND1 were specific to low/intermediate grade DCIS (rs75915166, rs554219). These associations with grade remained after adjusting for ER status and were also found in IDC. We found no novel DCIS-specific loci at a genome wide significance level of P < 5.0x10-8. Conclusion: In conclusion, this study provides the strongest evidence to date of a shared genetic susceptibility for IDC and DCIS. Studies with larger numbers of DCIS are needed to determine if IDC or DCIS specific loci exist
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