Origins of the Ambient Solar Wind: Implications for Space Weather

The Sun's outer atmosphere is heated to temperatures of millions of degrees, and solar plasma flows out into interplanetary space at supersonic speeds. This paper reviews our current understanding of these interrelated problems: coronal heating and the acceleration of the ambient solar wind. We also discuss where the community stands in its ability to forecast how variations in the solar wind (i.e., fast and slow wind streams) impact the Earth. Although the last few decades have seen significant progress in observations and modeling, we still do not have a complete understanding of the relevant physical processes, nor do we have a quantitatively precise census of which coronal structures contribute to specific types of solar wind. Fast streams are known to be connected to the central regions of large coronal holes. Slow streams, however, appear to come from a wide range of sources, including streamers, pseudostreamers, coronal loops, active regions, and coronal hole boundaries. Complicating our understanding even more is the fact that processes such as turbulence, stream-stream interactions, and Coulomb collisions can make it difficult to unambiguously map a parcel measured at 1 AU back down to its coronal source. We also review recent progress -- in theoretical modeling, observational data analysis, and forecasting techniques that sit at the interface between data and theory -- that gives us hope that the above problems are indeed solvable.Comment: Accepted for publication in Space Science Reviews. Special issue connected with a 2016 ISSI workshop on "The Scientific Foundations of Space Weather." 44 pages, 9 figure

Liposomes in the chemotherapy of experimental murine malaria

SCOPUS: le.jinfo:eu-repo/semantics/publishe

Primaquine liposomes in the chemotherapy of experimental murine malaria

Due to a significant reduction of toxicity, 100% curative (causal prophylactic) doses of primaquine diphosphate entrapped in liposomes (60 and 70 mg/kg body weight) can be administered in a single intravenous injection to treat sporozoite-induced Plasmodium bergheiinfections of mice.Although drug activity is not enhanced as compared to free drug, a simplified experimental therapy scheme could be developed, which may facilitate comparative pharmacokinetic studies of various drug delivery systems. © 1980 Liverpool School of Tropical Medicine.SCOPUS: ar.jinfo:eu-repo/semantics/publishe