Sexuality, disability, and reproductive issues through the lifespan

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45558/1/11195_2005_Article_BF01102578.pd

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers

A silicon diverging beam modulator fabricated by part of metal-oxide-silicon process modules

We hereby report a silicon diverging beam modulator fabricated by part of metal-oxide-silicon process modules. The particular feature of the fabrication is that a mode modulation technique is utilized. This technique changes intensity confinement of the propagation modes of a silicon partial waveguide such that an intensity modulation is achieved. Modulation indices of greater than 15% have been observed with a forward-bias current of 24 mA and a modulation length of 3 mm. By reducing the core width of the modulator, the modulation index can be further increased

Stigma and Help-Seeking among Arab Muslim College Students in the U.S.

Stigma is a primary barrier to mental health services. Arab Muslim college students report a disproportional negative association between stigma and help-seeking. This poster will examine the impact of instructor support on Arab Muslim students’ perceptions of stigma and treatment-seeking behaviors. Implications for counseling psychologists will be reviewed

Career decision making among gifted students: The mediation of teachers

There is international concern about falling enrollments in higher education, particularly the sciences, by gifted students. In this mixed method study, the top performing 200 students (approximately 1%) within a particular education jurisdiction at the beginning of their first year at university were surveyed and 20 interviewed about their school experiences using a biographical interpretive design. This study focussed on identifying those characteristics of teachers which supported students’ interests. Participants identified seven characteristics of teachers that students identified as supportive of their potential career pathways. These included connecting pedagogical practices with student interests, being passionate about their subject matter, having good content knowledge, making learning experiences relevant, setting high expectations of students, being a good explainer of complex ideas, and being a good classroom manager. This study extends our knowledge of how teachers influence gifted students and has implications for both pre-service and in-service teacher education and career counselling