411 research outputs found

    Linking teaching and research in disciplines and departments

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    This paper supports the effective links between teaching and discipline-based research in disciplinary communities and in academic departments. It is authored by Alan Jenkins, Mick Healey and Roger Zetter

    Contestation and reconstruction: natural capital and post-conflict development in borderland regions

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    Though often remote and underdeveloped, borderlands are contested territories. The incorporation of borderlands into the post-conflict state highlights many important land-related paradigms, including the conversion of natural resources for economic, political, and civic purposes. This article explores the relationship between the natural resources of borderlands and their post-conflict development, management, and sustainability. Based on case study data and secondary material drawn from Croatia and Cyprus, the paper seeks to establish how the interplay of cross-border, national, and sub-national interests in post-conflict settings may contribute to the creation of new opportunities for economic development and the reconstruction of borderlands. It considers how the exploitation of natural resources may advance the agendas for the political development and incorporation of previous sites of contestation; and equally how their incorporation may constrain policies of sustainability, potentially giving rise to new conflicts. The paper sheds light on issues such as: the conversion of borderland natural capital to political capital as post-conflict states assert sovereignty claims and consolidate territorial identity; the ways in which the non-monetary value of natural capital is reconceived as commercial use value in post-conflict reconstruction; and the involvement of non-state actors and civil society in promoting environmental agendas, often as a counterbalance to state power

    Long-term culture of capillary endothelial cells.

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    Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by β1 integrins

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    The anti-angiogenic effect of thrombospondin-1 has been shown to be mediated through binding of the type-1 repeat (TSR) domain to the CD36 transmembrane receptor. We now report that the TSR domain can inhibit VEGF-induced migration in human umbilical vein endothelial cells (HUVEC), cells that lack CD36. Moreover, we identified β1 integrins as a critical receptor in TSR-mediated inhibition of migration in HUVEC. Using pharmacological inhibitors of downstream VEGF receptor effectors, we found that phosphoinositide 3-kinase (PI3k) was essential for TSR-mediated inhibition of HUVEC migration, but that neither PLCγ nor Akt was necessary for this response. Furthermore, β1 integrins were critical for TSR-mediated inhibition of microvascular endothelial cells, cells that express CD36. Together, our results indicate that β1 integrins mediate the anti-migratory effects of TSR through a PI3k-dependent mechanism

    Correction

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    Accommodating 'others'?: housing dispersed, forced migrants in the UK

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    Utilising insights from a qualitative study in the city of Leeds (UK), this paper considers issues related to the housing of dispersed forced migrants. The term 'dispersed forced migrants' is used here as a general label to include four groups of international migrants (i.e. refugees, asylum seekers, those with humanitarian protection status and failed asylum seekers) who have previously been dispersed, on a no choice basis, to a variety of locations across the UK under the requirements of the Immigration and Asylum Act (1999). The tiering of housing entitlement that exists within the generic population of dispersed forced migrants (a consequence of the particular socio-legal status assigned to individuals), and its role in rendering migrants susceptible to homelessness is outlined. The adequacy/standard of accommodation made available to forced migrants is also discussed. It is concluded that current arrangements fail to meet the basic housing needs of many forced migrants. Any future improvement in this situation will require a significant shift in government policy
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