Renal fornix rupture following diagnostic coronarography

A 31-year-old man with an uneventful medical history presented at the emergency department with complaints of exercise-related chest pain for 3 weeks. ECG showed ST-elevations in the inferior leads. A diagnostic coronarography was performed and showed multivessel coronary stenosis. During this procedure 200 ml of a nonionic, low-osmolality monomeric contrast agent (Iomeron 350®) and 1250 ml of isotonic saline solution was administered intravenously. After this procedure, the patient suffered from a sudden onset and progressive severe pain in the back and the right lumbar region. A plain CT of the abdomen performed 8 hours post coronarography showed contrast enhanced fluid in the renal sinus and the perinephric/peri-ureteral space (Fig. A (scout view), B (coronal) and C (sagittal) reformatted scans). There was a bladder overdistenstion with a CT-based volumetric estimation of 995 ml. No mechanical cause of upper urinary tract obstruction was present. Subsequent urological work-up included insertion of a bladder catheter (24 hours) and administration of peroral antibiotics. Ultrasound follow-up on the next day revealed no abnormalities and the patient was discharged

Adaptations in the Temporalis Muscles of Rabbits after Masseter Muscle Removal

Masseter muscles were surgically removed in six young female rabbits so that we could study adaptations of the superficial temporalis muscles (ST) to increased functional requirements. Eight weeks following surgery, we used morphological measurements, histochemistry, contractile properties in situ, and occlusal force in vivo to compare the muscles in the experimental animals and six control rabbits. Analysis of the results demonstrated a decrease in fatigability of ST after masseter myectomy. Incisal occlusal force decreased by 65% during the first two weeks, and no recovery was observed during the following six weeks. At eight weeks post-surgery, the mass, twitch tensions, and tetanic tensions of ST were not significantly different from those of the controls. An increase in the percent of the cross-sectional area composed of fast fatigue-resistant fibers, a slower time-to-peak twitch tension, and a decrease in fatigability suggest an increase in oxidative metabolism. Analysis of these results suggests that muscles used for highly repetitious activities with submaximal loadings adapt to increased functional requirements by increasing fatigue-resistant properties.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68261/2/10.1177_00220345860650110201.pd

Why teachers are (less) academic optimistic : attributions and the impact of student population and school culture

Abstract: Teacher academic optimism (TAO) is a teacher characteristic influencing student achievement, even after controlling for SES and migration background. Academically optimistic teachers believe they can make a difference, build trusting relationships with students and parents, and focus on learning. This study examines how teachers attribute causes for high or low levels of TAO (RQ1) and what role student population and school academic optimism (SAO) play in this (RQ2). Data were collected through semi-structured interviews with 16 teachers from eight secondary schools differing by student population and SAO. Analyses show that teachers attribute high degrees of TAO using various causes. In contrast, a low degree is attributed only to causes outside themselves and outside their control. Moreover, it appears that the composition of student population does not, but the degree of SAO does play a role. Teachers in academically optimistic schools speak differently about their students, their school, and their job. This implies that through the attributions teachers make, work can be done to create AO

Organ-specific genome diversity of replication-competent SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not always confined to the respiratory system, as it impacts people on a broad clinical spectrum from asymptomatic to severe systemic manifestations resulting in death. Further, accumulation of intra-host single nucleotide variants during prolonged SARS-CoV-2 infection may lead to emergence of variants of concern (VOCs). Still, information on virus infectivity and intra-host evolution across organs is sparse. We report a detailed virological analysis of thirteen postmortem coronavirus disease 2019 (COVID-19) cases that provides proof of viremia and presence of replication-competent SARS-CoV-2 in extrapulmonary organs of immunocompromised patients, including heart, kidney, liver, and spleen (NCT04366882). In parallel, we identify organ-specific SARS-CoV-2 genome diversity and mutations of concern N501Y, T1027I, and Y453F, while the patient had died long before reported emergence of VOCs. These mutations appear in multiple organs and replicate in Vero E6 cells, highlighting their infectivity. Finally, we show two stages of fatal disease evolution based on disease duration and viral loads in lungs and plasma. Our results provide insights about the pathogenesis and intra-host evolution of SARS-CoV-2 and show that COVID-19 treatment and hygiene measures need to be tailored to specific needs of immunocompromised patients, even when respiratory symptoms cease. Here the authors provide a detailed virological analysis of thirteen postmortem COVID-19 cases, including presence of replication-competent SARS-CoV-2 in extrapulmonary organs and tissue-specific patterns of SARS-CoV-2 genome diversity of an immunocompromised patient