116 research outputs found

    Revision of the age of magnetization of the Montmartin red beds, Normandy, France

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    A new roadcut has enabled us to sample the south-dipping limb of the Montmartin syncline for a palaeomagnetic reevaluation of an earlier result published by Jones, Van der Voo & Bonhommet. In combination with the results previously published in 1979 for the north-dipping beds of the syncline, a conclusively negative fold test is obtained. The resulting magnetization (declination/inclination =206°/-3°, Α 95 = 12°, palaeopole at 38°S, 325°E) is interpreted to be of Late Carboniferous age, not Late Devonian as thought earlier. Simultaneously, we have re-evaluated the age of the rocks, previously thought to be Late Devonian on the basis of Acritarchs, Chitinozoans and spores. It has not been possible to reconfirm these fossils, not even in the same samples as studied originally; in contrast, the regional presence of Early Palaeozoic fossils suggests to us an age similar to that of other red beds in the Arrnorican Massif, which have been dated as Early Ordovician. The geodynamic implications of our finding that the Montmartin rocks are completely remagnetized, however, are of no great consequence for the geodynamics of the Hercynian belt. Pre-folding magnetization obtained from Silurian and Devonian rocks in Spain and Germany argue for the same conclusion as reached erroneously in our earlier study, namely that the Armorican Massif and adjacent parts of Hercynian Europe were adjointed to North America, Great Britain, the Baltic Shield and the Russian Platform since at least Late Devonian time. If a Medio-European ocean existed during the Palaeozoic, it was virtually closed before the mid-Devonian and of insignificant width during Culm deposition in Early Carboniferoirs time.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74719/1/j.1365-246X.1985.tb05108.x.pd

    Unique Signature of Dark Matter in Ancient Mica

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    Mica can store (for >1 Gy) etchable tracks caused by atoms recoiling from WIMPs. Because a background from fission neutrons will eventually limit this technique, a unique signature for WIMPs in ancient mica is needed. Our motion around the center of the Galaxy causes WIMPs, unlike neutrons, to enter the mica from a preferred direction on the sky. Mica is a directional detector and despite the complex rotations that natural mica crystals make with respect to this WIMP ``wind,'' there is a substantial dependence of etch pit density on present day mica orientation.Comment: 5 pages, LaTeX, 2 figures. Accepted for publication at Phys. Rev. Let

    Discovering Cooperative Relationships of Chromatin Modifications in Human T Cells Based on a Proposed Closeness Measure

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    BACKGROUND: Eukaryotic transcription is accompanied by combinatorial chromatin modifications that serve as functional epigenetic markers. Composition of chromatin modifications specifies histone codes that regulate the associated gene. Discovering novel chromatin regulatory relationships are of general interest. METHODOLOGY/PRINCIPAL FINDINGS: Based on the premise that the interaction of chromatin modifications is hypothesized to influence CpG methylation, we present a closeness measure to characterize the regulatory interactions of epigenomic features. The closeness measure is applied to genome-wide CpG methylation and histone modification datasets in human CD4+T cells to select a subset of potential features. To uncover epigenomic and genomic patterns, CpG loci are clustered into nine modules associated with distinct chromatin and genomic signatures based on terms of biological function. We then performed Bayesian network inference to uncover inherent regulatory relationships from the feature selected closeness measure profile and all nine module-specific profiles respectively. The global and module-specific network exhibits topological proximity and modularity. We found that the regulatory patterns of chromatin modifications differ significantly across modules and that distinct patterns are related to specific transcriptional levels and biological function. DNA methylation and genomic features are found to have little regulatory function. The regulatory relationships were partly validated by literature reviews. We also used partial correlation analysis in other cells to verify novel regulatory relationships. CONCLUSIONS/SIGNIFICANCE: The interactions among chromatin modifications and genomic elements characterized by a closeness measure help elucidate cooperative patterns of chromatin modification in transcriptional regulation and help decipher complex histone codes

    JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes

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    JHDM1B is an evolutionarily conserved and ubiquitously expressed member of the JHDM (JmjC-domain-containing his- tone demethylase) family1\u20133. Because it contains an F-box motif, this protein is also known as FBXL10 (ref. 4). With the use of a genome-wide RNAi screen, the JHDM1B worm orthologue (T26A5.5) was identified as a gene that regulates growth5. In the mouse, four independent screens have identified JHDM1B as a putative tumour suppressor by retroviral insertion analysis6\u20139. Here we identify human JHDM1B as a nucleolar protein and show that JHDM1B preferentially binds the transcribed region of ribosomal DNA to repress the transcription of ribosomal RNA genes. We also show that repression of ribosomal RNA genes by JHDM1B is dependent on its JmjC domain, which is necessary for the specific demethylation of trimethylated lysine 4 on histone H3 in the nucleolus. In agreement with the notion that ribosomal RNA synthesis and cell growth are coupled processes, we show a JmjC-domain-dependent negative effect of JHDM1B on cell size and cell proliferation. Because aberrant ribosome biogenesis and the disruption of epigenetic control mechanisms contribute to cellular transformation, these results, together with the low levels of JHDM1B expression found in aggressive brain tumours, suggest a role for JHDM1B in cancer development

    Refining Gondwana and Pangea palaeogeography: estimates of Phanerozoic non-dipole (octupole) fields

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    Reliable Phanerozoic paleopoles have been selected from the stable parts of the Gondwana continents and, upon appropriate reconstruction, have been combined in an apparent polar wander (APW) path, which can be compared with a previously compiled path for Laurussia. This comparison once again confirms that Pangea-A reconstructions for Late Palaeozoic and early Mesozoic times cannot be reconciled with the available paleomagnetic data, unless these data are corrected for latitudinal errors caused by non-dipole (octupole) field contributions or by inclination shallowing. Because the discrepancies persist even when only paleopoles from igneous rocks are used, inclination shallowing cannot be the sole cause of the problem. There is an apparent decrease in the percentage of octupole field contributions needed as a function of time; for Mesozoic and younger time, Gondwana–Laurussia comparisons require, on average, lower ratios of octupole/dipole fields than for Palaeozoic time. However, the Gondwana paleopoles for the Palaeozoic include a much greater proportion of results derived from sedimentary rocks than do those for the Mesozoic, so that this apparently diminishing octupole field contribution may be an artefact. We have also examined whether the clustering of coeval Gondwana poles improves with optimal G3 contributions, but found that while there are improvements, they are not systematic and not statistically significant. A combined APW path has been constructed for Pangea for times since the Mid-Carboniferous, which accounts for octupole fields, or equivalently, inclination shallowing. We argue that this ‘global’ path is an improvement over previous constructions as it represents a self-consistent plate tectonic model and does not violate widely accepted Pangea-A reconstructions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75220/1/j.1365-246X.2002.01799.x.pd
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