2 research outputs found
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse
pressure) among UK Biobank participants of European ancestry with independent replication
in other cohorts, leading to discovery and validation of 107 novel loci. We also identify new
independent variants at 11 previously reported blood pressure loci. Combined with results
from a range of in-silico functional analyses and wet bench experiments, our findings highlight
new biological pathways for blood pressure regulation enriched for genes expressed in
vascular tissues and identify potential therapeutic targets for hypertension. Results from
genetic risk score models raise the possibility of a precision medicine approach through early
lifestyle intervention to offset the impact of blood pressure raising variants on future
cardiovascular disease risk
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
The arcOGEN Consortium should be listed as an author of this article. They contributed to the genome-wide association study results presented in this work. They should be listed in the author byline at position 292 and affiliated with The Arthritis Research UK Osteoarthritis Genetics Consortium. They should also be included in the footnote designating consortia which is underneath the author affiliation list in the PDF version of the article, and in the S2 Text. Please view the correct S2 Text below, containing correct consortia members. S2 Text. Consortia members and extended acknowledgments.
https://doi.org/10.1371/journal.pgen.1006166.s001
(DOCX) [This corrects the article DOI: 10.1371/journal.pgen.1005378.]