2 research outputs found
Antiproliferative Compounds from <i>Cleistanthus boivinianus</i> from the Madagascar Dry Forest
The two new lignans 3α-<i>O</i>-(β-d-glucopyranosyl)desoxypodophyllotoxin
(<b>1</b>) and
4-<i>O</i>-(β-d-glucopyranosyl)dehydropodophyllotoxin
(<b>2</b>) were isolated from <i>Cleistanthus boivinianus</i>, together with the known lignans deoxypicropodophyllotoxin (<b>3</b>), (±)-β-apopicropodophyllin (<b>4</b>),
(−)-desoxypodophyllotoxin (<b>5</b>), (−)-yatein
(<b>6</b>), and β-peltatin-5-<i>O</i>-β-d-glucopyranoside (<b>7</b>). The structures of all compounds
were characterized by spectroscopic techniques. Compounds <b>1</b>, <b>4</b>, and <b>5</b> showed potent antiproliferative
activities against the A2780 ovarian cancer cell line, with IC<sub>50</sub> values of 33.0 ± 3.6, 63.1 ± 6.7, and 230 ±
1 nM, respectively. Compounds <b>2</b> and <b>7</b> showed
only modest A2780 activities, with IC<sub>50</sub> values of 2.1 ±
0.3 and 4.9 ± 0.1 μM, respectively, while compounds <b>3</b> and <b>6</b> had IC<sub>50</sub> values of >10
μM.
Compound <b>1</b> also had potent antiproliferative activity
against the HCT-116 human colon carcinoma cell line, with an IC<sub>50</sub> value of 20.5 nM, and compound <b>4</b> exhibited
modest antiproliferative activity against the A2058 human caucasian
metastatic melanoma and MES-SA human uterine sarcoma cell lines, with
IC<sub>50</sub> values of 4.6 and 4.0 μM, respectively