15 research outputs found
ПРЕДПОСЫЛКИ К ПОНИМАНИЮ МЕХАНИЗМОВ РАЗВИТИЯ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ
The article presents data on the growth and development of breast tissue. A detailed morphogenesis mammary gland, occurring in mammary epithelium during the life of the woman with the changes of the stroma was presented.В статье представлены данные о росте и развитии ткани молочной железы. Приведен подробный морфогенез молочной железы с привязкой процессов, происходящих с эпителием молочной железы в течении жизни женщины, с изменениями стромы.
ЖИРОВАЯ ТКАНЬ, ЕЕ РОЛЬ В РАЗВИТИИ И МЕТАСТАЗИРОВАНИИ РАКА (НА ПРИМЕРЕ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ)
On the basis of world literature data described anatomic features of structure of human breast, demonstrated the processes occurring in the breast tissue in breast cancer, described some of the molecular mechanisms of interaction between cancer cells and adipocytes.В статье на основе данных мировой литературы описаны анатомические особенности строения молочной железы человека, продемонстрированы процессы происходящие в тканях молочной железы при раке молочной железы, описаны некоторые молекулярные механизмы взаимодействия раковых клеток и адипоцитов
Minimally Invasive Treatment of Benign Thyroid Nodules
Background. Nodular goitre is the commonest pathology of thyroid gland. According to published evidence, the endemic prevalence of iodine deficiency varies within 19–76 % population. The high rates and lack of symptoms at progressive nodules growth warrant the development of effective organ-preserving treatments. Imaging techniques for local precision targeting of individual lesions enable maximum-preserving interventions at thyroid tissue. Today’s world experience of percutaneous ethanol sclerotherapy and radiofrequency ablation is adequate. However, there exist no clear indications for sclerotherapy and radiofrequency ablation, and their consecutive use has not been assessed.Materials and methods. We analyse minimally invasive organ-preserving treatments of benign thyroid nodules (ethanol sclerotherapy, RFA) in 63 patients at the outpatient and general surgery units of BSMU Clinic and MEGI Medical Centre, Ufa, during February 2019 — December 2020.Results and discussion. Ethanol sclerotherapy was highly effective in 46.5 % patients, as evident from discontinued nodule’s blood supply in CDI and B-mode ultrasound, which remained stable in 10.5 % and restored after 3–4 weeks in 25 % patients. Sclerotherapy in colloid goitre was efficient only in 37.5 % patients. Ethanol sclerotherapy was RFA-followed in 25.4 % patients. RFA was favoured at a low-effective sclerotherapy providing for a weak positive dynamics of nodule size, local parietal blood flow preservation and intranodular vessels recanalisation at re-examination.Conclusion. Sclerotherapy was high-effective in cystic nodules. Radiofrequency ablation can be considered most adequate for treating solid nodules. RFA-followed sclerotherapy is a rational choice in treatment of large cystic nodules (>5 cm3 )
Мини-инвазивные способы лечения доброкачественных узлов щитовидной железы
Background. Nodular goitre is the commonest pathology of thyroid gland. According to published evidence, the endemic prevalence of iodine deficiency varies within 19–76 % population. The high rates and lack of symptoms at progressive nodules growth warrant the development of effective organ-preserving treatments. Imaging techniques for local precision targeting of individual lesions enable maximum-preserving interventions at thyroid tissue. Today’s world experience of percutaneous ethanol sclerotherapy and radiofrequency ablation is adequate. However, there exist no clear indications for sclerotherapy and radiofrequency ablation, and their consecutive use has not been assessed.Materials and methods. We analyse minimally invasive organ-preserving treatments of benign thyroid nodules (ethanol sclerotherapy, RFA) in 63 patients at the outpatient and general surgery units of BSMU Clinic and MEGI Medical Centre, Ufa, during February 2019 — December 2020.Results and discussion. Ethanol sclerotherapy was highly effective in 46.5 % patients, as evident from discontinued nodule’s blood supply in CDI and B-mode ultrasound, which remained stable in 10.5 % and restored after 3–4 weeks in 25 % patients. Sclerotherapy in colloid goitre was efficient only in 37.5 % patients. Ethanol sclerotherapy was RFA-followed in 25.4 % patients. RFA was favoured at a low-effective sclerotherapy providing for a weak positive dynamics of nodule size, local parietal blood flow preservation and intranodular vessels recanalisation at re-examination.Conclusion. Sclerotherapy was high-effective in cystic nodules. Radiofrequency ablation can be considered most adequate for treating solid nodules. RFA-followed sclerotherapy is a rational choice in treatment of large cystic nodules (>5 cm3 ). Введение. Самой распространенной патологией щитовидной железы является узловой зоб. Встречаемость йододефицита в эндемических регионах варьирует, по литературным данным, от 19 до 76 % населения. Высокая распространенность, бессимптомное течение с прогрессирующим ростом узлов диктуют необходимость выработки эффективных органосохраняющих методов лечения. Имея визуализирующие способы локального прецизионного воздействия на отдельные патологически измененные структуры, можно выполнять вмешательства с максимальным сохранением неизмененной ткани щитовидной железы. На сегодня в мире уже накоплен достаточный опыт применения чрескожной склеротерапии этанолом и радиочастотной абляции (РЧА). Однако не разработаны четкие показания к применению склеротерапии и радиочастотной абляции и не оценена возможность последовательного их применения.Материалы и методы. В работе представлен анализ лечения доброкачественных узлов щитовидной железы мини-инвазивными органосохраняющими методами (этаноловая склеротерапия, РЧА) у 63 пациентов, проведенными на базе амбулаторного отделения и отделения общей хирургии Клиники Башкирского государственного медицинского института и медицинского центра «МЕГИ», г. Уфа, в период с февраля 2019 до декабря 2020 г.Результаты и обсуждение. Применение этаноловой склеротерапии было высокоэффективным у 46,5 % пациентов, оценку проводили по нарушению питания узла в виде исчезновения кровотока при УЗД исследовании в режиме ЦДК и B-flow, которое отмечалось в 10,5 % случаев — стабильное и в 25 % отмечено восстановление кровотока спустя 3–4 недели. При склеротерапии узлов с признаками организации коллоида эффективность отмечена только у 37,5 % пациентов. У 25,4 % исследуемых после этаноловой склеротерапии была проведена последующая РЧА. Решение в пользу РЧА было принято при малоэффективном курсе склеротерапии в виде слабой положительной динамики размеров узла, сохранения пристеночных локусов кровотока и реканализации внутринодулярных сосудов при повторном осмотре.Заключение. Высокая эффективность склерозирующей терапии отмечалась при кистозном характере узла. В лечении узлов, имеющих солидный характер, лучшим методом следует признать радиочастотную деструкцию. При лечении кистозно-трансформированных узлов больших размеров (более 5 см3 ) рационально проведение сеансов склеротерапии перед РЧА.
Synthesis, optical and electrochemical properties of new thieno[2,3-b]indole-based dyes
Three new push-pull dyes consisting of a thieno[2,3-b]indole ring system as an electron donor, thiophene spacer as a π-bridge, and electron-withdrawing moieties such as 2-methylene malonitrile, 2-methylene-1Hindene- 1,3(2H)-dione, and 2-(2-methylene-3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, have been synthesized and studied for their application in organic electronics devices. Investigation of their optical and electrochemical properties reveal that these compounds possess narrow band gaps (1.7-2 eV) and an effective absorption in the visible spectral range (440-740 nm). Therefore, these chromophores can be regarded as promising light-harvesting materials. © 2018 ARKAT USA, Inc.Russian Science Foundation, RSF: 16-13-10435This research study was financially supported by the Russian Science Foundation (Project No. 16-13-10435)
A global overview on the diet of the dice snake (Natrix tessellata) from a geographical perspective: foraging in atypical habitats and feeding spectrum widening helps colonisation and survival under suboptimal conditions for a piscivorous snake
PREREQUISITE TO UNDERSTANDING THE MECHANISMS OF DEVELOPMENT OF BREAST CANCER
The article presents data on the growth and development of breast tissue. A detailed morphogenesis mammary gland, occurring in mammary epithelium during the life of the woman with the changes of the stroma was presented
ADIPOSE TISSUE, ITS ROLE IN DEVELOPMENT AND CANCER METASTASIS (FOR EXAMPLE BREAST CANCER)
On the basis of world literature data described anatomic features of structure of human breast, demonstrated the processes occurring in the breast tissue in breast cancer, described some of the molecular mechanisms of interaction between cancer cells and adipocytes
Robot-assisted removal of the orbital tumor (from practice)
The implementation of robotic surgery, in particular the da Vinci surgical system, is one of the biggest breakthroughs in surgery since the invention of anesthesia, and represents the most significant achievement in minimally invasive surgery of this decade. If the use of the da Vinchi robotic system in pelvic surgery has long been the gold standard, the use of this system in surgery of the base of the skull and sinuses is quite rare and is currently more experimental. Due to the lack of description in the domestic and foreign literature, it seems interesting to us to demonstrate the clinical observation of a patient with an orbital tumor