Space-time Trends in U.S. Meteorological Droughts

Understanding droughts in a climate context remains a major challenge. Over the United States, different choices of observations and metrics have often produced diametrically opposite insights. This paper focuses on understanding and characterizing meteorological droughts from station measurements of precipitation. The Standardized Precipitation Index is computed and analyzed to obtain drought severity, duration and frequency. Average drought severity trends are found to be uncertain and data-dependent. Furthermore, the mean and spatial variance do not show any discernible non-stationary behavior. However, the spatial coverage of extreme meteorological droughts in the United States exhibits an increasing trend over nearly all of the last century. Furthermore, the coverage over the last half decade exceeds that of the dust bowl era. Previous literature suggests that climate extremes do not necessarily follow the trends or uncertainties exhibited by the averages. While this possibility has been suggested for droughts, this paper for the first time clearly delineates and differentiates the trends in the mean, variability and extremes of meteorological droughts in the United States, and uncovers the trends in the spatial coverage of extremes. Multiple data sets, as well as years exhibiting large, and possibly anomalous, droughts are carefully examined to characterize trends and uncertainties. Nonlinear dependence among meteorological drought attributes necessitates the use of copula-based tools from probability theory. Severity-duration-frequency curves are generated to demonstrate how these insights may be translated to design and policy

Polycystic ovary syndrome, blood group & diet: A correlative study in South Indian females

Aim: To find out the co-relation between polycystic ovary syndrome (PCOS) with blood group & diet in South Indian females, between the age-group of (20-30) years. Objectives: Correlative analysis of ABO & Rh system, dietary habits & alcohol consumption with PCOS. Materials & Methods: 100 patients between (20-30) years, diagnosed with PCOS were selected. A standard PCOS questionnaire was given. Blood group & dietary status data were collected. Patients were grouped according to ABO & Rh system considering their diet & alcohol intake (p≤0.05 significant). Result: Our data revealed that the highest risk of PCOS was observed in females with blood group ‘O’ positive followed by ‘B’ positive who were on mixed diet & used to consume alcohol. Our study also suggests that Rh negative individuals didn’t show any association with PCOS. Conclusion: The results of our study suggest that ‘O’ positive females, are more prone to PCOS. Though the relative frequency of B positive individuals are more in India, females with blood group O positive are more susceptible to PCOS, contributing factors being mixed diet & alcohol intake. So, early screening of ‘O’ positive &‘B’ positive females of reproductive age-group in South-India, could be used as a measure for timely diagnosis of PCOS, better management &also prevention of complications. However, further research should be done to investigate the multifaceted mechanisms triggering these effects

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration

Although microglial activation is widely found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the underlying mechanism(s) are poorly understood. Here, using human-induced pluripotent stem cell-derived microglia-like cells (hiPSC-MG) harboring the most common ALS/FTD mutation (C9orf72, mC9-MG), gene-corrected isogenic controls (isoC9-MG), and C9orf72 knockout hiPSC-MG (C9KO-MG), we show that reduced C9ORF72 protein is associated with impaired phagocytosis and an exaggerated immune response upon stimulation with lipopolysaccharide. Analysis of the C9ORF72 interactome revealed that C9ORF72 interacts with regulators of autophagy and functional studies showed impaired initiation of autophagy in mC9-MG and C9KO-MG. Coculture studies with motor neurons (MNs) demonstrated that the autophagy deficit in mC9-MG drives increased vulnerability of mC9-MNs to excitotoxic stimulus. Pharmacological activation of autophagy ameliorated both cell-autonomous functional deficits in hiPSC-MG and MN death in MG-MN coculture. Together, these findings reveal an important role for C9ORF72 in regulating immune homeostasis and identify dysregulation in myeloid cells as a contributor to neurodegeneration in ALS/FTD.</p

Polyphosphates as a source of enhanced P fluxes in marine sediments overlain by anoxic waters: Evidence from (31)P NMR

Sedimentary phosphorus (P) composition was investigated in Effingham Inlet, a fjord located on the west coast of Vancouver Island in Barkley Sound. Solid-state (31)P nuclear magnetic resonance (NMR) spectroscopy was applied to demineralized sediment samples from sites overlain by oxic and anoxic bottom waters. The two sites were similar in terms of key diagenetic parameters, including the mass accumulation rate, integrated sulfate reduction rate, and bulk sediment organic carbon content. In contrast, P benthic fluxes were much higher at the anoxic site. (31)P NMR results show that P esters and phosphonates are the major organic P species present at the surface and at depth in sediments at both sites. Polyphosphates were only found in the surface sediment of the site overlain by oxic waters. The varying stability of polyphosphates in microorganisms under different redox conditions may, in part, explain their distribution as well as differences in P flux between the two sites

Fitting the Elementary Rate Constants of the P-gp Transporter Network in the hMDR1-MDCK Confluent Cell Monolayer Using a Particle Swarm Algorithm

P-glycoprotein, a human multidrug resistance transporter, has been extensively studied due to its importance to human health and disease. In order to understand transport kinetics via P-gp, confluent cell monolayers overexpressing P-gp are widely used. The purpose of this study is to obtain the mass action elementary rate constants for P-gp's transport and to functionally characterize members of P-gp's network, i.e., other transporters that transport P-gp substrates in hMDR1-MDCKII confluent cell monolayers and are essential to the net substrate flux. Transport of a range of concentrations of amprenavir, loperamide, quinidine and digoxin across the confluent monolayer of cells was measured in both directions, apical to basolateral and basolateral to apical. We developed a global optimization algorithm using the Particle Swarm method that can simultaneously fit all datasets to yield accurate and exhaustive fits of these elementary rate constants. The statistical sensitivity of the fitted values was determined by using 24 identical replicate fits, yielding simple averages and standard deviations for all of the kinetic parameters, including the efflux active P-gp surface density. Digoxin required additional basolateral and apical transporters, while loperamide required just a basolateral tranporter. The data were better fit by assuming bidirectional transporters, rather than active importers, suggesting that they are not MRP or active OATP transporters. The P-gp efflux rate constants for quinidine and digoxin were about 3-fold smaller than reported ATP hydrolysis rate constants from P-gp proteoliposomes. This suggests a roughly 3∶1 stoichiometry between ATP hydrolysis and P-gp transport for these two drugs. The fitted values of the elementary rate constants for these P-gp substrates support the hypotheses that the selective pressures on P-gp are to maintain a broad substrate range and to keep xenobiotics out of the cytosol, but not out of the apical membrane

Understanding Successful Transfers of Rapid-Composting Technology Using Qualitative Content Analysis for Interpretation

956-965This study focuses on the transfer of technology of rapid composting of bio-waste from a Public-funded Mission-oriented Research Organization (PMRO) in India. The PMRO is engaged in developing nuclear power technologies, and applications of nuclear technologies to non-power areas such as agriculture, bioscience, health care, and industry. It also develops technologies for applications in many areas including electronics, computers, LASERs, and accelerators. The organisation encourages the transfer of spin-off technologies for commercialization as well as for scaling up under incubation on a non-exclusive basis. The technology under study has attracted a large clientele of over 50 transferee firms in 5 years. This paper explores motivations behind a large clientele. While academic literature substantially covers the technology transfers from universities, the PMROs, especially those in emerging economies have not received much attention from academics. This paper inter alia addresses this gap. Semi-structured interviews were conducted with the actors namely scientists, tech-transfer managers, and executives of transferee firms. Qualitative content analysis was carried out to arrive at the success-enabling factors, success-inhibiting factors, unique processes, and special roles of actors. Also, the paper brings out the strength of qualitative content analysis as a concept interpretation method in case study research. The paper highlights the synergistic interactions between the industry and the laboratory and provides useful tips for scientists, Tech-transfer Managers, and executives of transferee firms for making success in tech-transfers of societal and environmental technologies

Nutrition and addiction - are they linked in de-addictive process? A review

Background: Substance abuse has become a serious issue that is faced by the world. The effects of drug abuse can be detrimental to corporeal, psychological and societal well-being of a person. Drug misuse is actually unrestrained habit of drugs leading to inspiration of reward-system in brain Substance abuse also influences the food preferences and dietary habits of the users, therefore affecting the person’s nutrition. Instead of how frequently a person engages in the behavior, substance abuse and substance addiction are distinguished by how challenging it is for the person to manage without the behavior or quit it for a specific period of time.&nbsp; Methodology: Electronic databases were used to conduct a thorough, systematic analysis of research, which was restricted to those with English/English abstracts and used words like "addiction," "nutrition," "lifestyle," "alcohol," "reward system," "recreational substances," etc., Conclusion: An effort has been made in this research article to highlight the effects of various addictive substances on different systems in human body with the role of adequate nutrition to fight back this addiction for the overall betterment of the society