Pancreatic Enzyme Supplementation in Acute Pancreatitis

This study evaluates the effect of oral pancreatic enzyme supplements on pain, analgesic requirement and the incidence of complications in patients with acute pancreatitis. This double blind, prospectively randomised placebo controlled study included 23 patients. Pain was monitored using a visual analogue scale; the analgesic requirement was assessed with a numerical score

Screening effects in flow through rough channels

A surprising similarity is found between the distribution of hydrodynamic stress on the wall of an irregular channel and the distribution of flux from a purely Laplacian field on the same geometry. This finding is a direct outcome from numerical simulations of the Navier-Stokes equations for flow at low Reynolds numbers in two-dimensional channels with rough walls presenting either deterministic or random self-similar geometries. For high Reynolds numbers, when inertial effects become relevant, the distribution of wall stresses on deterministic and random fractal rough channels becomes substantially dependent on the microscopic details of the walls geometry. In addition, we find that, while the permeability of the random channel follows the usual decrease with Reynolds, our results indicate an unexpected permeability increase for the deterministic case, i.e., ``the rougher the better''. We show that this complex behavior is closely related with the presence and relative intensity of recirculation zones in the reentrant regions of the rough channel.Comment: 4 pages, 5 figure

Assessment of menopausal symptoms using modified menopause rating scale among urban women doctors of India

Background: The study was conducted to assess the commonly reported menopausal symptoms among urban women doctors using modified menopause rating scale (MRS).Methods: The study was carried out in the society by google link. Convenient sample of 100 women doctors were included in the study. Menopausal symptoms were assessed using modified MRS.Results: In present study, 3 (3%) female doctors had premature menopause, 5 had menopause at 40-44 years, 15 (15%) had menopause at 45-49 years, 77 (77%) had menopause while no patient had menopause after 55 years. Hot flushes were seen in 70 (79%) women, heart discomfort/ palpitation was seen in 2 (2%) women, muscle and joint problems were seen in 30 (30%) women, sleeping problems were seen in 20 (20%) women. Depressive mood was seen in 2 (2%) women, irritability was seen in 12 (12%) women, an anxiety was seen in 22 (22%) women while physical and mental exhaustion was seen in 34 (34%%) women. Sexual problems were seen in 32 (32%) women, bladder problems were seen in 8 (8%) women dryness of the vagina was seen in 35 (35%) women (Table 6).Conclusions: Hot flushes and joint problems were the most common followed by urogenital symptom, sleep disturbance, and anxiety in the study. Menopausal symptoms were less prevalent. Busy schedule, self-confidence due to independent nature and constructive work might be the reason

Autocatalytic plume pinch-off

A localized source of buoyancy flux in a non-reactive fluid medium creates a plume. The flux can be provided by either heat, a compositional difference between the fluid comprising the plume and its surroundings, or a combination of both. For autocatalytic plumes produced by the iodate-arsenous acid reaction, however, buoyancy is produced along the entire reacting interface between the plume and its surroundings. Buoyancy production at the moving interface drives fluid motion, which in turn generates flow that advects the reaction front. As a consequence of this interplay between fluid flow and chemical reaction, autocatalytic plumes exhibit a rich dynamics during their ascent through the reactant medium. One of the more interesting dynamical features is the production of an accelerating vortical plume head that in certain cases pinches-off and detaches from the upwelling conduit. After pinch-off, a new plume head forms in the conduit below, and this can lead to multiple generations of plume heads for a single plume initiation. We investigated the pinch-off process using both experimentation and simulation. Experiments were performed using various concentrations of glycerol, in which it was found that repeated pinch-off occurs exclusively in a specific concentration range. Autocatalytic plume simulations revealed that pinch-off is triggered by the appearance of accelerating flow in the plume conduit.Comment: 10 figures. Accepted for publication in Phys Rev E. See also http://www.physics.utoronto.ca/nonlinear/papers_chemwave.htm

Evaluation of the anti-depressant potential of metformin in conditioned defeat model in golden Syrian hamsters

Background: Depression is a prevalent mood condition that has an impact on daily functioning. Globally, depression affects 264 million people. The current pharmacotherapy of depression has a lot of shortcomings. Therefore, there is a need to explore newer therapy that alleviate the symptoms of depression. Metformin was found to possess antioxidant potential and hypothesized to decrease the levels of branched-chain amino-acids essential for tryptophan uptake (precursor for serotonin synthesis). The study was designed to validate the efficacy of metformin as an anti-depressant in conditioned defeat model in male golden Syrian hamsters using open field test (OFT), forced swim test (FST) and Serum serotonin levels. Methods: After obtaining IAEC approval, the study was carried out using 8 golden Syrian hamsters each that were randomly assigned to four groups. The disease control group received 1mL normal saline, positive control was given fluoxetine 12 mg/kg, two groups of metformin 240 mg/kg given pre-insult and post-insult. The variables assessed on every third day included OFT and FST. Following the behavioral tests, serotonin-ELISA was done. To analyse the outcomes, appropriate statistical tests were applied. Results: On standardization, the model was established to a 16-day model. Further, results highlighted a significant difference in OFT, FST and serotonin levels with the metformin group and fluoxetine compared to disease control (p<0.001). However, no significant difference was observed between the fluoxetine and metformin groups (p>0.05), signifying the comparable results. Conclusions: Metformin (240 mg/kg) alleviated the depressive symptoms by modulating both behavioral and serotonin levels

Adrenal sparing giant adrenal cyst excision by 3D laparoscopic approach: a case report

Adrenal cyst is rare clinical entity. Usually they are asymptomatic, non-functional, <10 cm in size and often discovered incidentally. We report a left adrenal cyst in 58-year-old woman measuring 23 cm in diameter, displacing left kidney infero-medially and pancreas anteriorly, because of its huge size. She presented with left flank pain over a 6-month period. Serial abdominal ultrasound and CT imaging revealed left suprarenal cystic mass of size 10 cm to begin with and gradually increased to size of 23 cm over period of 10 years when she became symptomatic. All laboratory and endocrine function tests were normal. 3D laparoscopic surgery done and cyst was completely removed with preservation of adrenal gland. Histopathological examination revealed a benign endothelial adrenal cyst. The postoperative course was uneventful and patient had no evidence of recurrence during follow-up. The giant adrenal cysts are relatively rare and represent great surgical challenge during resection.

Flagellar Motility Is a Key Determinant of the Magnitude of the Inflammasome Response to Pseudomonas aeruginosa

We previously demonstrated that bacterial flagellar motility is a fundamental mechanism by which host phagocytes bind and ingest bacteria. Correspondingly, loss of bacterial motility, consistently observed in clinical isolates from chronic Pseudomonas aeruginosa infections, enables bacteria to evade association and ingestion of P. aeruginosa by phagocytes both in vitro and in vivo. Since bacterial interactions with the phagocyte cell surface are required for type three secretion system-dependent NLRC4 inflammasome activation by P. aeruginosa, we hypothesized that reduced bacterial association with phagocytes due to loss of bacterial motility, independent of flagellar expression, will lead to reduced inflammasome activation. Here we report that inflammasome activation is reduced in response to nonmotile P. aeruginosa. Nonmotile P. aeruginosa elicits reduced IL-1β production as well as caspase-1 activation by peritoneal macrophages and bone marrow-derived dendritic cells in vitro. Importantly, nonmotile P. aeruginosa also elicits reduced IL-1β levels in vivo in comparison to those elicited by wild-type P. aeruginosa. This is the first demonstration that loss of bacterial motility results in reduced inflammasome activation and antibacterial IL-1β host response. These results provide a critical insight into how the innate immune system responds to bacterial motility and, correspondingly, how pathogens have evolved mechanisms to evade the innate immune system

Aeolian transport layer

We investigate the airborne transport of particles on a granular surface by the saltation mechanism through numerical simulation of particle motion coupled with turbulent flow. We determine the saturated flux $q_{s}$ and show that its behavior is consistent with a classical empirical relation obtained from wind tunnel measurements. Our results also allow to propose a new relation valid for small fluxes, namely, $q_{s}=a(u_{*}-u_{t})^{\alpha}$, where $u_{*}$ and $u_{t}$ are the shear and threshold velocities of the wind, respectively, and the scaling exponent is $\alpha \approx 2$. We obtain an expression for the velocity profile of the wind distorted by the particle motion and present a dynamical scaling relation. We also find a novel expression for the dependence of the height of the saltation layer as function of the wind velocity.Comment: 4 pages, 4 figure