366 research outputs found
SUMMARY OF EXPERIMENTAL RESULTS 1979 GENERAL PHOSPHOROUS TRIALS
Contiuing trials Stock rate and level of Superhosphate on cyprus medic pasture 66M30 Rates of phosphorus, sulphur and stocking trial - cropping phase 68BR7 Maintenance P x S trials 65N5, 69WH15, 65A1, 65c6 Residual Value of Phosphorus 78M08, 78C4, 78MA2, 75LG26, 78M38 NEW TRIALS Crops N x P Trials 79NA11, 79NA12, 79NA13 Times of P on Lupins 79M030 Lupin and Oat Mixtures 79BA31, 79MT30 Methods Application and Cultivation of P on Wheat 79M1, 79WH1 Methods and Times of P on Wheat Old Land 79N1 Rates of Super on Wheat 79LG Rates of Super on Lupins 79GE PASTURES Rates of P, K and S on Pasture - Dandaragan 79M012, 79M013, 79M015, 79M017 Rates of P, K and S on Pasture – Lancelin 79M011, 79M018 Rates of P on Pasture – Newdegate 79N5, 79N6 Rates of P x Species on Pasture 79N05, 79JE
Phosphorus and sulphur group
Long Term Trials Stocking and superphosphate trials - 66M30, 68BR7. Maintenance Phosphorus x Sulphur trials - 65A1, 65N5, 65C5, 69WH15, 68B1, 69AL3 and 67N05. Low Rainfall Crops and Pastures. Residual phosphorus trials - 76ES8, 75KA4, 75LG26 and 76NA5. Miscellaneous Cropping Trials. Rate of phosphorus on wheat - 77ES2, 77ME5, 77N03. N. P and seed rates on wheat - 77JE1. Row spacing, phosphorus and seed rate on wheat - 77ME6. Phosphorus on nitrogen build up - 77M033. Rate of super on old land lupins - 77A18 & 19, 77BA13 & 14, 77E20. Pasture Trials. Phosphorus and Sulphur on old land pasture - 77BA 17, 18, 19, 20, 21 , 22, 23 and 24. High Rainfall Pasture Trials. Current and residual phosphorus - 75AL5, 75DE5, 75DE7, 75BR13, 76BU13(a), 76KE10 and 76MA2. Phosphorus and Sulphur 1977 Phosphorus Soil Test Series - 77AL5, 77AL6, 77HA10, 77DE6 & 7, 77BR14, 15, 16, 17, 18 & 19, 77BU6 & 7, 77BY3
General phosphorus and sulphur trials
(A) Long Term Trials/Trial number: Super x Stocking Rate - 66M30. Super Sulphur and Stocking Rate - 68BR7. Maintenance P and S trials - 69E6, 68B1, 65A1, 65N5, 65C5, 69WH15 & 67N05. Continuous Cropping - 75LG26. Cropping Residual Value - 29M/148, 149. (B) Lupin Trials: Rate of P and S - 78A8, 78A9, 78BA9, 78BA10, 78C5, 78C6, 78E8, 78E9, 78WH7, 78WH8 & 78NA25. Current and Residual phosphorus - 75KA4. (C) Cereal Trials: Depth of Placement of P on Wheat - 78M38. Row spacing x P rates on Wheat - 78ME4. Current and Residual Nitrogen on Wheat - 77M033. (D) Pasture Trials: Times of application - 77BA38. Residual value - 77BA21, 78BA7, 77BA22, 77BA24, 78M010. Rates of Phosphorus - 78M011. P and S on irrigated pastures - 77HA10
Super and stocking rates at Kojonup after 10 years
A Department of Agriculture trial on old land at Kojonup has been comparing rates of superphosphate and stocking of sheep for 10 years
Phosphorus and sulphur interactions, 1978.
Yield results, 78AL3, 78KE4, 78M08, 78BY3, 78BA8, 78BU3, 78N04, 78A7, 78C4, 78B4, 78MA2.
Soil sampling data
Post-operative immune suppression is reversible with interferon gamma and independent of IL-6 pathways
Introduction
The post-operative period is characterised by increased IL-6 production and clinical features of immune suppression. In vitro anti-inflammatory actions of IL-6 are mediated through suppression of interferon gamma (IFNγ) [1]. The clinical significance of IL-6 in mediating post-operative immune suppression remains unclear.
Objectives
To evaluate the role of IL-6 pathways in post-operative immune suppression and the reversibility of this phenomenon.
Methods
Patients over 45 years old undergoing elective surgery involving the gastrointestinal tract and requiring at least an overnight hospital stay were recruited. The primary outcome was hospital-acquired infection. IL-6 and IFNγ levels were assayed using ELISA preoperatively and at 24 and 48 hours. Pooled healthy control peripheral blood mononuclear cells (PBMCs) were cultured in perioperative serum and CD14+HLA-DR (mHLA-DR) geometric mean florescent intensity (MFI) measured in the presence and absence of interferon gamma (IFNγ) and IL-6 neutralising antibody. Data were analysed with non-parametric statistics.
Results
119 patients were recruited and 44 (37%) developed a post-operative infection a median of 9 (IQR 5-11) days postoperatively (Figure 1). IL-6 levels increased from baseline to 24 hours postoperatively (P < 0.0001, Figure 1A) but were then unchanged between 24 and 48 hours (P = 0.06, Figure 1B). Postoperative IL-6 levels correlated with the duration of the procedure (P = 0.009). Higher preoperative IL-6 levels were observed in patients with cancer (P = 0.02). IL-6 levels at 24 (P = 0.0002) and 48 hours (P = 0.003) were associated with the later occurrence of infectious complications. This pattern remained similar after adjustment for baseline characteristics. Healthy donor PBMCs incubated with postoperative serum downregulated mHLA-DR MFI when compared with serum from baseline (n = 8, p = 0.008). Culturing in the presence of IFNγ 250IU (n = 4) prevented this decrease whereas culturing in the presence of IL-6 neutralising antibody 15ng/ml (n = 8) did not.
Conclusions
IL-6 levels increase following major surgery and are associated with an increased susceptibility to post-operative infections. Serum obtained from post-operative patients induces an immunosuppressive response through an IL-6 independent pathways which is reversible with IFNγ treatment
Unstable coronal loops : numerical simulations with predicted observational signatures
We present numerical studies of the nonlinear, resistive magnetohydrodynamic
(MHD) evolution of coronal loops. For these simulations we assume that the
loops carry no net current, as might be expected if the loop had evolved due to
vortex flows. Furthermore the initial equilibrium is taken to be a cylindrical
flux tube with line-tied ends. For a given amount of twist in the magnetic
field it is well known that once such a loop exceeds a critical length it
becomes unstableto ideal MHD instabilities. The early evolution of these
instabilities generates large current concentrations. Firstly we show that
these current concentrations are consistent with the formation of a current
sheet. Magnetic reconnection can only occur in the vicinity of these current
concentrations and we therefore couple the resistivity to the local current
density. This has the advantage of avoiding resistive diffusion in regions
where it should be negligible. We demonstrate the importance of this procedure
by comparison with simulations based on a uniform resistivity. From our
numerical experiments we are able to estimate some observational signatures for
unstable coronal loops. These signatures include: the timescale of the loop
brightening; the temperature increase; the energy released and the predicted
observable flow speeds. Finally we discuss to what extent these observational
signatures are consistent with the properties of transient brightening loops.Comment: 13 pages, 9 figure
Features of postoperative immune suppression are reversible with interferon gamma and independent of interleukin-6 pathways
OBJECTIVE
The aim of this study was to evaluate the role of interleukin (IL)-6 pathways in postoperative immune suppression and to assess the reversibility of this phenomenon.
BACKGROUND
The postoperative period is characterized by increased IL-6 production and features of immune suppression. In vitro, IL-6 mediates anti-inflammatory effects through inhibition of interferon gamma (IFN-γ) pathways. The significance of the immunomodulatory effects of IL-6 in the clinical setting of postoperative immune suppression remains unclear.
METHODS
Patients over 45 years old undergoing elective surgery, involving the gastrointestinal tract, were recruited. IL-6 levels were assayed using an enzyme linked immunosorbent assay preoperatively, and at 24 and 48 hours. Peripheral blood mononuclear cells from healthy volunteers were cultured in perioperative serum and CD14Human Leukocyte Antigen-DR (HLA-DR) [monocyte HLA-DR (mHLA-DR)] geometric mean florescent intensity was measured in the presence and absence of IL-6 neutralizing antibody and recombinant IFN-γ.
RESULTS
Of the 108 patients, 41 developed a postoperative infection. The IL-6 levels increased 19-fold from the preoperative sample to 24 hours postoperatively (P < 0.0001). Higher IL-6 levels at 24 (P = 0.0002) and 48 hours (P = 0.003) were associated with subsequent postoperative infectious complications. mHLA-DR mean florescent intensity fell when healthy peripheral blood mononuclear cells were cultured with postoperative serum compared with preoperative serum (P = 0.008). This decrease was prevented by the presence of IFN-γ in the culture media, but not by the presence of IL-6-neutralizing antibody.
CONCLUSIONS
IL-6 levels increase after a major surgery and are associated with an increased susceptibility to postoperative infections. Serum obtained from postoperative patients induces an immunosuppressive response, reflected in reduced mHLA-DR levels, mediated through IL-6 independent pathways and is reversible with IFN-γ. These data may have therapeutic implications for the prevention of infection in patients undergoing major surgery
Trauma and violence informed care through decolonising interagency partnerships: A complexity case study of waminda’s model of systemic decolonisation
Through the lens of complexity, we present a nested case study describing a decolonisation approach developed and implemented by Waminda South Coast Women\u27s Health and Welfare Aboriginal Corporation. Using Indigenous research methods, this case study has unfolded across three phases: 1) Yarning interviews with the workforce from four partner health services (n = 24); 2) Yarning circle bringing together key informants from yarning interviews to verify and refine emerging themes (n = 14); 3) Semi-structured interviews with a facilitator of Waminda\u27s Decolonisation Workshop (n = 1) and participants (n = 10). Synthesis of data has been undertaken in stages through collaborative framework and thematic analysis. Three overarching themes and eight sub-themes emerged that centred on enhancing the capabilities of the workforce and strengthening interagency partnerships through a more meaningful connection and shared decolonisation agenda that centres Aboriginal and Torres Strait Islander families and communities. Health and social services are complex systems that function within the context of colonisation. Waminda’s innovative, model of interagency collaboration enhanced workforce capability through shared language and collective learning around colonisation, racism and Whiteness. This process generated individual, organisational and systemic decolonisation to disable power structures through trauma and violence informed approach to practice
1976 Phosphorus and sulphur group
Stocking x Super. rate trials - 66M30, 62MB9, 68BR7. Crossed plot trials - residual value. P x K on Pasture - 74TS4, 74M06, 75GE6. N x P on· Wheat - 75M09. P x Species - 75LG4, 75JE5. Maintenance P x S trials - Wheat Belt Research Station - 65A1; C5, N5, 69WH15. High Rainfall Areas - 68B1, 69E6, 69AL2. Farmers residual value - 66N07, 66ME3,67N011, 66NA3, 66LG1, 68LG1, 66M06, 67M01, 67GE2, 67N05, 67N04, 66N09. Miscellaneous Cropping Trials - Super x Spacing - 76ME26, 76ES8, 9 and 10. Super Study rate and spacing - 76NA7, 76N05, 76JE8. Continuous cropping - 75LG26, 75ES7. Rates, Methods and times of Super - 76KA3, 76JE3. Super on old land lupins - 76BA3 & 4, 76A4 76E3 & 4, 76WH7 & 8. High Rainfall Pasture Trials - 1976 Soil Testing Series - 76BY3,·4, 5, &·6, Skirrow 76BR10, 11, 12, 16 & 17. 76HA2; 3, 4, 5, 6 & 7 76KE5, 6, 7, 8, 9 & 10. 76MA5 & 6. P x S series - 76KE3 & 4, 76MA2 & 4. Cross Plot x Soil test series - 75AL5, 75DE2, 3, 4, 5 & 7. 75Bu8 & 10, 75BY6 & 8 75BR11, 12 & 13, 75AR4, 75HA7
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