24 research outputs found
The role of hemorrhage following spinal-cord injury.
Spinal-cord injury is characterized by primary damage as a direct consequence of mechanical insult, and secondary damage that is partly due to the acute inflammatory response. The extent of any hemorrhage within the injured cord is also known to be associated with the formation of intraparenchymal cavities and has been anecdotally linked to secondary damage. This study was designed to examine the contribution of blood components to the outcome of spinal-cord injury. We stereotaxically microinjected collagenase, which causes localized bleeding, into the spinal cord to model the hemorrhage associated with spinal cord injury in the absence of significant mechanical trauma. Tissue damage was observed at the collagenase injection site over time, and was associated with localized disruption of the blood-spinal-cord barrier, neuronal cell death, and the recruitment of leukocytes. The magnitude of the bleed was related to neutrophil mobilization. Interestingly, the collagenase-induced injury also provoked extended axonal damage. With this model, the down-stream effects of hemorrhage are easily discernible, and the impact of treatment strategies for spinal-cord injury on hemorrhage-related injury can be evaluated
The role of hemorrhage following spinal-cord injury
Spinal-cord injury is characterized by primary damage as a direct consequence of mechanical insult, and secondary damage that is partly due to the acute inflammatory response. The extent of any hemorrhage within the injured cord is also known to be associated with the formation of intraparenchymal cavities and has been anecdotally linked to secondary damage. This study was designed to examine the contribution of blood components to the outcome of spinal-cord injury. We stereotaxically microinjected collagenase, which causes localized bleeding, into the spinal cord to model the hemorrhage associated with spinal cord injury in the absence of significant mechanical trauma. Tissue damage was observed at the collagenase injection site over time, and was associated with localized disruption of the blood-spinal-cord barrier, neuronal cell death, and the recruitment of leukocytes. The magnitude of the bleed was related to neutrophil mobilization. Interestingly, the collagenase-induced injury also provoked extended axonal damage. With this model, the down-stream effects of hemorrhage are easily discernible, and the impact of treatment strategies for spinal-cord injury on hemorrhage-related injury can be evaluated. © 2014 Elsevier Inc. All rights reserved
Targeting albumin excretion rate in the treatment of the hypertensive diabetic patient with renal disease
Bragg-Diffraction Imaging: A Potential Technique for Medical Diagnosis and Material Inspection
Targeting albumin excretion rate in the treatment of the hypertensive diabetic patient with renal disease
Correct Prediction of the Vibration Behavior of a High Power Ultrasonic Transducer by FEM Simulation
Correct Prediction of the Vibration Behavior of the High Power Ultrasonic Transducers by Fem Simulation
Subsurface Broadband Acoustic Microscopy of Solids using Aperture Lenses
The imaging of interior planes in a solid object involves difficulties with spherical aberration, with the elimination of the front surface echo, and with the need in some cases to use signal processing techniques in order to enhance the signal-to-noise ratio. This paper shows that suitably designed spherical lenses can be used to minimize the spherical aberration. The elimination of the front surface echo requires careful time-gating and very short, broadband pulses. It is shown by using extended chirp pulses, the signal-to-noise ratio for subsurface objects can be very greatly improved. A number of examples of the use of these techniques for NDE are presented.</p