The second-order electron self-energy in hydrogen-like ions

A calculation of the simplest part of the second-order electron self-energy (loop after loop irreducible contribution) for hydrogen-like ions with nuclear charge numbers $3 \leq Z \leq 92$ is presented. This serves as a test for the more complicated second-order self-energy parts (loop inside loop and crossed loop contributions) for heavy one-electron ions. Our results are in strong disagreement with recent calculations of Mallampalli and Sapirstein for low $Z$ values but are compatible with the two known terms of the analytical $Z\alpha$-expansion.Comment: 13 LaTex pages, 2 figure

Loop-after-loop contribution to the second-order Lamb shift in hydrogenlike low-Z atoms

We present a numerical evaluation of the loop-after-loop contribution to the second-order self-energy for the ground state of hydrogenlike atoms with low nuclear charge numbers Z. The calculation is carried out in the Fried-Yennie gauge and without an expansion in Z \alpha. Our calculation confirms the results of Mallampalli and Sapirstein and disagrees with the calculation by Goidenko and coworkers. A discrepancy between different calculations is investigated. An accurate fitting of the numerical results provides a detailed comparison with analytic calculations based on an expansion in the parameter Z \alpha. We confirm the analytic results of order \alpha^2 (Z\alpha)^5 but disagree with Karshenboim's calculation of the \alpha^2 (Z \alpha)^6 \ln^3(Z \alpha)^{-2} contribution.Comment: RevTex, 19 pages, 4 figure

Toward high-precision values of the self energy of non-S states in hydrogen and hydrogen-like ions

The method and status of a study to provide numerical, high-precision values of the self-energy level shift in hydrogen and hydrogen-like ions is described. Graphs of the self energy in hydrogen-like ions with nuclear charge number between 20 and 110 are given for a large number of states. The self-energy is the largest contribution of Quantum Electrodynamics (QED) to the energy levels of these atomic systems. These results greatly expand the number of levels for which the self energy is known with a controlled and high precision. Applications include the adjustment of the Rydberg constant and atomic calculations that take into account QED effects.Comment: Minor changes since previous versio

A P53-TLR3 Axis Ameliorates Pulmonary Hypertension by Inducing BMPR2 Via IRF3

Pulmonary arterial hypertension (PAH) features pathogenic and abnormal endothelial cells (ECs), and one potential origin is clonal selection. We studied the role of p53 and toll-like receptor 3 (TLR3) in clonal expansion and pulmonary hypertension (PH) via regulation of bone morphogenetic protein (BMPR2) signaling. ECs of PAH patients had reduced p53 expression. EC-specific p53 knockout exaggerated PH, and clonal expansion reduced p53 and TLR3 expression in rat lung CD117+ ECs. Reduced p53 degradation (Nutlin 3a) abolished clonal EC expansion, induced TLR3 and BMPR2, and ameliorated PH. Polyinosinic/polycytidylic acid [Poly(I:C)] increased BMPR2 signaling in ECs via enhanced binding of interferon regulatory factor-3 (IRF3) to the BMPR2 promoter and reduced PH in p53−/− mice but not in mice with impaired TLR3 downstream signaling. Our data show that a p53/TLR3/IRF3 axis regulates BMPR2 expression and signaling in ECs. This link can be exploited for therapy of PH

Strategies and methods to study sex differences in cardiovascular structure and function: a guide for basic scientists

<p>Abstract</p> <p>Background</p> <p>Cardiovascular disease remains the primary cause of death worldwide. In the US, deaths due to cardiovascular disease for women exceed those of men. While cultural and psychosocial factors such as education, economic status, marital status and access to healthcare contribute to sex differences in adverse outcomes, physiological and molecular bases of differences between women and men that contribute to development of cardiovascular disease and response to therapy remain underexplored.</p> <p>Methods</p> <p>This article describes concepts, methods and procedures to assist in the design of animal and tissue/cell based studies of sex differences in cardiovascular structure, function and models of disease.</p> <p>Results</p> <p>To address knowledge gaps, study designs must incorporate appropriate experimental material including species/strain characteristics, sex and hormonal status. Determining whether a sex difference exists in a trait must take into account the reproductive status and history of the animal including those used for tissue (cell) harvest, such as the presence of gonadal steroids at the time of testing, during development or number of pregnancies. When selecting the type of experimental animal, additional consideration should be given to diet requirements (soy or plant based influencing consumption of phytoestrogen), lifespan, frequency of estrous cycle in females, and ability to investigate developmental or environmental components of disease modulation. Stress imposed by disruption of sleep/wake cycles, patterns of social interaction (or degree of social isolation), or handling may influence adrenal hormones that interact with pathways activated by the sex steroid hormones. Care must be given to selection of hormonal treatment and route of administration.</p> <p>Conclusions</p> <p>Accounting for sex in the design and interpretation of studies including pharmacological effects of drugs is essential to increase the foundation of basic knowledge upon which to build translational approaches to prevent, diagnose and treat cardiovascular diseases in humans.</p

One-loop self-energy correction to the 1s and 2s hyperfine splitting in H-like systems

The one-loop self-energy correction to the hyperfine splitting of the 1s and 2s levels in H-like low-Z atoms is evaluated to all orders in Z\alpha. The results are compared to perturbative calculations. The residual higher-order contribution is evaluated. Implications to the specific difference of the hyperfine structure intervals 8\Delta \nu_2 - \Delta \nu_1 in He^+ are investigated.Comment: 17 pages, RevTeX, 3 figure

The Standard Model in Strong Fields: Electroweak Radiative Corrections for Highly Charged Ions

Electroweak radiative corrections to the matrix elements $<ns_{1/2}|{\hat H}_{PNC}|n'p_{1/2}>$ are calculated for highly charged hydrogenlike ions. These matrix elements constitute the basis for the description of the most parity nonconserving (PNC) processes in atomic physics. The operator ${\hat H}_{PNC}$ represents the parity nonconserving relativistic effective atomic Hamiltonian at the tree level. The deviation of these calculations from the calculations valid for the momentum transfer $q^{2}=0$ demonstrates the effect of the strong field, characterized by the momentum transfer $q^{2}=m_{e}^{2}$ ($m_{e}$ is the electron mass). This allows for a test of the Standard Model in the presence of strong fields in experiments with highly charged ions.Comment: 27 LaTex page

Electron Self Energy for the K and L Shell at Low Nuclear Charge

A nonperturbative numerical evaluation of the one-photon electron self energy for the K- and L-shell states of hydrogenlike ions with nuclear charge numbers Z=1 to 5 is described. Our calculation for the 1S state has a numerical uncertainty of 0.8 Hz in atomic hydrogen, and for the L-shell states (2S and 2P) the numerical uncertainty is 1.0 Hz. The method of evaluation for the ground state and for the excited states is described in detail. The numerical results are compared to results based on known terms in the expansion of the self energy in powers of (Z alpha).Comment: 21 pages, RevTeX, 5 Tables, 6 figure

QCD Corrections to QED Vacuum Polarization

We compute QCD corrections to QED calculations for vacuum polarization in background magnetic fields. Formally, the diagram for virtual $e\bar{e}$ loops is identical to the one for virtual $q\bar{q}$ loops. However due to confinement, or to the growth of $\alpha_s$ as $p^2$ decreases, a direct calculation of the diagram is not allowed. At large $p^2$ we consider the virtual $q\bar{q}$ diagram, in the intermediate region we discuss the role of the contribution of quark condensates \left and at the low-energy limit we consider the $\pi^0$, as well as charged pion $\pi^+\pi^-$ loops. Although these effects seem to be out of the measurement accuracy of photon-photon laboratory experiments they may be relevant for $\gamma$-ray burst propagation. In particular, for emissions from the center of the galaxy (8.5 kpc), we show that the mixing between the neutral pseudo-scalar pion $\pi_0$ and photons renders a deviation from the power-law spectrum in the $TeV$ range. As for scalar quark condensates \left and virtual $q\bar{q}$ loops are relevant only for very high radiation density $\sim 300 MeV/fm^3$ and very strong magnetic fields of order $\sim 10^{14} T$.Comment: 15 pages, 4 figures; Final versio

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum