98 research outputs found
Existential Communication and Leadership
The aim of this article is to introduce and explain a number of important existentialist philosophers and concepts that we believe can contribute to a critical approach to leadership theory. Emphasis is placed on understanding the nature of communication from an existentialist perspective and so Jaspers' conceptualization of existential communication is introduced along with important related concepts that may be regarded as important facets of leader communication including Being-in-the-world, the Other, intersubjectivity, dialogue and indirect communication. Particular attention is paid to Buber's ideas on communication as relationship and dialogue. Throughout, reference is made to contemporary, and what is often regarded as orthodox, thinking regarding the centrality of communication to leadership practice as a means by which to highlight the salience of an existentialist analysis
Morphine metabolism, transport and brain disposition
The chemical structures of morphine and its metabolites are closely related to the clinical effects of drugs (analgesia and side-effects) and to their capability to cross the Blood Brain Barrier (BBB). Morphine-6-glucuronide (M6G) and Morphine-3-glucuronide (M3G) are both highly hydrophilic, but only M6G can penetrate the BBB; accordingly, M6G is considered a more attractive analgesic than the parent drug and the M3G. Several hypotheses have been made to explain these differences. In this review we will discuss recent advances in the field, considering brain disposition of M6G, UDP-glucoronosyltransferases (UGT) involved in morphine metabolism, UGT interindividual variability and transport proteins
University-industry relationships and open innovation: Towards a research agenda
Accepted versio
From Description to Interpretive Leap: Using Philosophical Notions to Unpack and Surface Meaning in Hermeneutic Phenomenology Research
Hermeneutic phenomenology (HP) as research method is increasingly used in health and social science studies to collect and analyze lived experiential descriptions (LEDs) of a phenomenon. However, currently there is little guidance in how to apply philosophical notions to interpret LEDs in HP studies and this approach has faced critique in how meaning is attributed. In this paper, we offer clarity about what “we do” in HP studies. It does not present a comparative analysis of qualitative approaches or claim to present an inflexible “how to” menu. The purpose is to provide guidance to those new to this methodology or/and for less experienced supervisors of postgraduate research students using this approach for the first time. The focus is specifically on conducting HP research and how philosophical notions are used to inform methodological decisions. Drawing upon data from our empirical projects we illuminate how meaning is surfaced, demonstrating a key feature of HP studies in the use of philosophical notions to uncover ontological significance. Consideration is also offered on how trustworthiness in HP studies can be achieved. The key contention is how the philosophical underpinnings of HP thinking, and the constant call to be reflexive, draws forth hitherto unspoken meaning that can inform new thinking and practice
The first case of Brucella canis in Sweden: background, case report and recommendations from a northern European perspective
Infection with Brucella canis has been diagnosed in Sweden for the first time. It was diagnosed in a three-year-old breeding bitch with reproductive disturbances. Fifteen in-contact dogs were tested repeatedly and all of them were negative for B. canis. The source of infection could not be defined. The present article describes the case and the measures undertaken and gives a short review over B. canis. Recommendations on how to avoid the infection in non-endemic countries are given
Diversely functionalised carbohydrate-centered oligomers and polymers. Thermoresponsivity, lectin binding and degradability
Nature is capable of synthesizing perfectly defined, sequence-controlled oligomers and polymers, whereas synthetic polymerization methods inherently give rise to dispersity and limited reproducibility. This inherent dispersity provides a barrier to translation into biomedical applications and for probing material-biology interactions. Templating of polymers based upon biosynthesized cores offers a route to reproducible oligo/polymers if the template itself is readily available and highly tunable. Here oligosaccharides are employed as monodisperse scaffolds for the synthesis of highly functional biomaterials. The pendant hydroxyl units are converted to reactive methacrylates, which are themselves amenable for thiol-ene (‘click’) functionalization. Using this strategy, extremely well defined (MW/MN < 1.05) polymers are prepared bearing thermoresponsive or lectin-binding moieties. The templatation strategy ensures identical polymers are obtained from each synthesis. Their thermoresponsive behavior and multivalent interactions with a bacterial lectin are studied as a function of the discrete number of functional groups. Due to the ester linkage, these polymers are also shown to be inherently degradable
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