CP violation and CKM phases from angular distributions for BsB_s decays into admixtures of CP eigenstates

We investigate the time-evolutions of angular distributions for $B_s$ decays into final states that are admixtures of CP-even and CP-odd configurations. A sizable lifetime difference between the $B_s$ mass eigenstates allows a probe of CP violation in time-dependent untagged angular distributions. Interference effects between different final state configurations of $B_s\to D^{*+}_s D^{*-}_s$, $J/\psi \phi$ determine the Wolfenstein parameter $\eta$ from untagged data samples, or -- if one uses $|V_{ub}|/|V_{cb}|$ as an additional input -- the notoriously difficult to measure CKM angle $\gamma$. Another determination of $\gamma$ is possible by using isospin symmetry of strong interactions to relate untagged data samples of $B_s\to K^{\ast+} K^{\ast-}$ and $B_s\to K^{\ast0} \overline{K^{\ast0}}$. We note that the untagged angular distribution for $B_s\to\rho^0 \phi$ provides interesting information about electroweak penguins.Comment: 19 pages, LaTeX, no figure

Pd/Cu Site Interchange and Non-Fermi-Liquid Behavior in UCu_4Pd

X-ray-absorption fine-structure measurements of the local structure in UCu_4Pd are described which indicate a probable lattice-disorder origin for non-Fermi-liquid behavior in this material. Short Pd-Cu distances are observed, consistent with 24 +/- 3% of the Pd atoms occupying nominally Cu sites. A "Kondo disorder" model, based on the effect on the local Kondo temperature T_K of this interchange and some additional bond-length disorder, agrees quantitatively with previous experimental susceptibility data, and therefore also with specific heat and magnetic resonance experiments.Comment: 4 pages, 3 PostScript figures, to be published in PR

Incorporating development of a patient-reported outcome instrument in a clinical drug development program: examples from a heart failure program.

BackgroundPatient-reported outcome (PRO) measures can be used to support label claims if they adhere to US Food & Drug Administration guidance. The process of developing a new PRO measure is expensive and time-consuming. We report the results of qualitative studies to develop new PRO measures for use in clinical trials of omecamtiv mecarbil (a selective, small molecule activator of cardiac myosin) for patients with heart failure (HF), as well as the lessons learned from the development process.MethodsConcept elicitation focus groups and individual interviews were conducted with patients with HF to identify concepts for the instrument. Cognitive interviews with HF patients were used to confirm that no essential concepts were missing and to assess patient comprehension of the instrument and items.ResultsDuring concept elicitation, the most frequently reported HF symptoms were shortness of breath, tiredness, fluid retention, fatigue, dizziness/light-headedness, swelling, weight fluctuation, and trouble sleeping. Two measures were developed based on the concepts: the Heart Failure Symptom Diary (HF-SD) and the Heart Failure Impact Scale (HFIS). Findings from cognitive interviews suggested that the items in the HF-SD and HFIS were relevant and well understood by patients. Multiple iterations of concept elicitation and cognitive interviews were needed based on FDA request for a broader patient population in the qualitative study. Lessons learned from the omecamtiv mecarbil PRO/clinical development program are discussed, including challenges of qualitative studies, patient recruitment, expected and actual timelines, cost, and engagement with various stakeholders.ConclusionDevelopment of a new PRO measure to support a label claim requires significant investment and early planning, as demonstrated by the omecamtiv mecarbil program

Exclusive Hadronic D Decays to eta' and eta

Hadronic decay modes $D^0\to(\bar K^0, \bar K^{*0})\eta,\eta'$ and $(D^+,D_s^+)\to(\pi^+,\rho^+)\eta,\eta'$ are studied in the generalized factorization approach. Form factors for $(D,D_s^+)\to(\eta,\eta')$ transitions are carefully evaluated by taking into account the wave function normalization of the eta and eta'. The predicted branching ratios are generally in agreement with experiment except for $D^0\to\bar K^0\eta', D^+\to\pi^+\eta$ and $D_s^+\to\rho^+\eta'$; the calculated decay rates for the first two decay modes are too small by an order of magnitude. We show that the weak decays $D^0\to K^-\pi^+$ and $D^+\to K^+\bar K^0$ followed by resonance-induced final-state interactions (FSI), which are amenable technically, are able to enhance the branching ratios of $D^0\to\bar K^0\eta'$ and $D^+\to\pi^+\eta$ dramatically without affecting the agreement between theory and experiment for $D^0\to\bar K^0\eta$ and $D^+\to\pi^+\eta'$. We argue that it is difficult to understand the observed large decay rates of $D_s^+\to \rho^+\eta'$ and $\rho^+\eta$ simultaneously; FSI, W-annihilation and the production of excess eta' from gluons are not helpful in this regard. The large discrepancy between the factorization hypothesis and experiment for the ratio of $D_s^+\to\rho^+ \eta'$ and $D_s^+\to\eta' e^+\nu$ remains as an enigma.Comment: 15 pages, 1 figure, to appear in Phys. Rev. D. Form factors for D to eta and eta' transitions are slightly change

Analog quantum error correction

Quantum error-correction routines are developed for continuous quantum variables such as position and momentum. The result of such analog quantum error correction is the construction of composite continuous quantum variables that are largely immune to the effects of noise and decoherence.Comment: Ten pages, Te

Information Content in B→VVB \to VV Decays and the Angular Moments Method

The time-dependent angular distributions of decays of neutral $B$ mesons into two vector mesons contain information about the lifetimes, mass differences, strong and weak phases, form factors, and CP violating quantities. A statistical analysis of the information content is performed by giving the ``information'' a quantitative meaning. It is shown that for some parameters of interest, the information content in time and angular measurements combined may be orders of magnitude more than the information from time measurements alone and hence the angular measurements are highly recommended. The method of angular moments is compared with the (maximum) likelihood method to find that it works almost as well in the region of interest for the one-angle distribution. For the complete three-angle distribution, an estimate of possible statistical errors expected on the observables of interest is obtained. It indicates that the three-angle distribution, unraveled by the method of angular moments, would be able to nail down many quantities of interest and will help in pointing unambiguously to new physics.Comment: LaTeX, 34 pages with 9 figure

Final-State Phases in Charmed Meson Two-Body Nonleptonic Decays

Observed decay rates indicate large phase differences among the amplitudes for the charge states in $D \to \bar K \pi$ and $D \to \bar K^* \pi$ but relatively real amplitudes in the charge states for $D \to \bar K \rho$. This feature is traced using an SU(3) flavor analysis to a sign flip in the contribution of one of the amplitudes contributing to the latter processes in comparison with its contribution to the other two sets. This amplitude may be regarded as an effect of rescattering and is found to be of magnitude comparable to others contributing to charmed particle two-body nonleptonic decays.Comment: 19 pages, latex, 4 figures, to be submitted to Phys. Rev.

Exploring CP Violation with BcB_c Decays

We point out that the pure ``tree'' decays $B_c^\pm\to D^\pm_s D$ are particularly well suited to extract the CKM angle $\gamma$ through amplitude relations. In contrast to conceptually similar strategies using $B^\pm\to K^\pm D$ or $B_d\to K^{\ast0} D$ decays, the advantage of the $B_c$ approach is that the corresponding triangles have three sides of comparable length and do not involve small amplitudes. Decays of the type $B_c^\pm\to D^\pm D$ -- the $U$-spin counterparts of $B_c^\pm\to D^\pm_s D$ -- can be added to the analysis, as well as channels, where the $D^\pm_s$- and $D^\pm$-mesons are replaced by higher resonances.Comment: 9 pages, LaTeX, 3 figures, reference adde

Complex Curve of the Two Matrix Model and its Tau-function

We study the hermitean and normal two matrix models in planar approximation for an arbitrary number of eigenvalue supports. Its planar graph interpretation is given. The study reveals a general structure of the underlying analytic complex curve, different from the hyperelliptic curve of the one matrix model. The matrix model quantities are expressed through the periods of meromorphic generating differential on this curve and the partition function of the multiple support solution, as a function of filling numbers and coefficients of the matrix potential, is shown to be the quasiclassical tau-function. The relation to softly broken N=1 supersymmetric Yang-Mills theories is discussed. A general class of solvable multimatrix models with tree-like interactions is considered.Comment: 36 pages, 10 figures, TeX; final version appeared in special issue of J.Phys. A on Random Matrix Theor