Multifacet holographic optical elements

New types of holographic optical elements, combining the flexibility of computer generated holograms with the large space bandwidth product and high diffraction efficiency of interferometrically recorded volume phase holograms, are demonstrated. The optical elements are recorded by subdividing a volume hologram film surface into numerous small areas (facets), each of which is individually exposed under computer control. Each facet is used to produce a portion of the desired final wavefront. Three different optical elements are demonstrated

Remote sensing of land use and water quality relationships - Wisconsin shore, Lake Michigan

This investigation assessed the utility of remote sensing techniques in the study of land use-water quality relationships in an east central Wisconsin test area. The following types of aerial imagery were evaluated: high altitude (60,000 ft) color, color infrared, multispectral black and white, and thermal; low altitude (less than 5000 ft) color infrared, multispectral black and white, thermal, and passive microwave. A non-imaging hand-held four-band radiometer was evaluated for utility in providing data on suspended sediment concentrations. Land use analysis includes the development of mapping and quantification methods to obtain baseline data for comparison to water quality variables. Suspended sediment loads in streams, determined from water samples, were related to land use differences and soil types in three major watersheds. A multiple correlation coefficient R of 0.85 was obtained for the relationship between the 0.6-0.7 micrometer incident and reflected radiation data from the hand-held radiometer and concurrent ground measurements of suspended solids in streams. Applications of the methods and baseline data developed in this investigation include: mapping and quantification of land use; input to watershed runoff models; estimation of effects of land use changes on stream sedimentation; and remote sensing of suspended sediment content of streams. High altitude color infrared imagery was found to be the most acceptable remote sensing technique for the mapping and measurement of land use types

Land use and pollution patterns on the Great Lakes

The author has identified the following significant results. The final mapping of the large watersheds of the Manitowoc and the Oconto was done using the 25% sampling approach. Comparisons were made with earlier strip mapping efforts of the Oconto and Manitowoc watersheds. Regional differences were noted. Strip mapping of the Oconto resulted in overestimation of the amount of agricultural land compared to the random sampling method. For the Manitowoc, the strip mapping approach produced a slight underestimate of agricultural land, and an overestimate of the forest category

Is nonhelical hydromagnetic turbulence peaked at small scales?

Nonhelical hydromagnetic turbulence without an imposed magnetic field is considered in the case where the magnetic Prandtl number is unity. The magnetic field is entirely due to dynamo action. The magnetic energy spectrum peaks at a wavenumber of about 5 times the minimum wavenumber in the domain, and not at the resistive scale, as has previously been argued. Throughout the inertial range the spectral magnetic energy exceeds the kinetic energy by a factor of about 2.5, and both spectra are approximately parallel. At first glance, the total energy spectrum seems to be close to k^{-3/2}, but there is a strong bottleneck effect and it is suggested that the asymptotic spectrum is k^{-5/3}. This is supported by the value of the second order structure function exponent that is found to be \zeta_2=0.70, suggesting a k^{-1.70} spectrum.Comment: 6 pages, 6 figure

Suppression of small scale dynamo action by an imposed magnetic field

Non-helical hydromagnetic turbulence with an externally imposed magnetic field is investigated using direct numerical simulations. It is shown that the imposed magnetic field lowers the spectral magnetic energy in the inertial range. This is explained by a suppression of the small scale dynamo. At large scales, however, the spectral magnetic energy increases with increasing imposed field strength for moderately strong fields, and decreases only slightly for even stronger fields. The presence of Alfven waves is explicitly confirmed by monitoring the evolution of magnetic field and velocity at one point. The frequency omega agrees with vA k1, where vA is the Alfven speed and k1 is the smallest wavenumber in the box.Comment: Final version (7 pages

Skylab imagery: Application to reservoir management in New England

The author has identified the following significant results. S190B imagery is superior to the LANDSAT imagery for land use mapping and is as useful for level 1 and 2 land use mapping as the RB-57/RC8 high altitude imagery. Detailed land use mapping at levels 3 and finer from satellite imagery requires better resolution. For evaluating factors that are required to determine volume runoff potentials in a watershed, the S190B imagery was found to be as useful as the RB-57/RC8 high altitude aircraft imagery

The "zeroth law" of turbulence: Isotropic turbulence simulations revisited

The dimensionless kinetic energy dissipation rate C_epsilon is estimated from numerical simulations of statistically stationary isotropic box turbulence that is slightly compressible. The Taylor microscale Reynolds number Re_lambda range is 20 < Re_lambda < 220 and the statistical stationarity is achieved with a random phase forcing method. The strong Re_lambda dependence of C_epsilon abates when Re_lambda approx. 100 after which C_epsilon slowly approaches approx 0.5 a value slightly different to previously reported simulations but in good agreement with experimental results. If C_epsilon is estimated at a specific time step from the time series of the quantities involved it is necessary to account for the time lag between energy injection and energy dissipation. Also, the resulting value can differ from the ensemble averaged value by up to +-30%. This may explain the spread in results from previously published estimates of C_epsilon.Comment: 7 pages, 7 figures. Submitted to Phys. Rev.

Inhibition of nuclear factor-kappa B differentially affects thyroid cancer cell growth, apoptosis, and invasion

<p>Abstract</p> <p>Background</p> <p>Nuclear factor-κB (NF-κB) is constitutively activated in many cancers and plays a key role in promoting cell proliferation, survival, and invasion. Our understanding of NF-κB signaling in thyroid cancer, however, is limited. In this study, we have investigated the role of NF-κB signaling in thyroid cancer cell proliferation, invasion, and apoptosis using selective genetic inhibition of NF-κB in advanced thyroid cancer cell lines.</p> <p>Results</p> <p>Three pharmacologic inhibitors of NF-κB differentially inhibited growth in a panel of advanced thyroid cancer cell lines, suggesting that these NF-κB inhibitors may have off-target effects. We therefore used a selective genetic approach to inhibit NF-κB signaling by overexpression of a dominant-negative IκBα (mIκBα). These studies revealed decreased cell growth in only one of five thyroid cancer cell lines (8505C), which occurred through a block in the S-G2/M transition. Resistance to TNFα-induced apoptosis was observed in all cell lines, likely through an NF-κB-dependent mechanism. Inhibition of NF-κB by mIκBα sensitized a subset of cell lines to TNFα-induced apoptosis. Sensitive cell lines displayed sustained activation of the stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) pathway, defining a potential mechanism of response. Finally, NF-κB inhibition by mIκBα expression differentially reduced thyroid cancer cell invasion in these thyroid cancer cell lines. Sensitive cell lines demonstrated approximately a two-fold decrease in invasion, which was associated with differential expression of MMP-13. MMP-9 was reduced by mIκBα expression in all cell lines tested.</p> <p>Conclusions</p> <p>These data indicate that selective inhibition of NF-κB represents an attractive therapeutic target for the treatment of advanced thyroid. However, it is apparent that global regulation of thyroid cancer cell growth and invasion is not achieved by NF-κB signaling alone. Instead, our findings suggest that other important molecular processes play a critical role in defining the extent of NF-κB function within cancer cells.</p

Inertial range scaling in numerical turbulence with hyperviscosity

Numerical turbulence with hyperviscosity is studied and compared with direct simulations using ordinary viscosity and data from wind tunnel experiments. It is shown that the inertial range scaling is similar in all three cases. Furthermore, the bottleneck effect is approximately equally broad (about one order of magnitude) in these cases and only its height is increased in the hyperviscous case--presumably as a consequence of the steeper decent of the spectrum in the hyperviscous subrange. The mean normalized dissipation rate is found to be in agreement with both wind tunnel experiments and direct simulations. The structure function exponents agree with the She-Leveque model. Decaying turbulence with hyperviscosity still gives the usual t^{-1.25} decay law for the kinetic energy, and also the bottleneck effect is still present and about equally strong.Comment: Final version (7 pages