Effect of Processing Parameters on the Density and Microstructure of Direct Laser Sintered Al-12Si Powders

The effect of processing parameters on the sintering behaviour of gas atomised Al-12Si powders has been investigated. Laser power, scanning rate, scan spacing and layer thickness are found to control the densification and the resultant microstructural characteristics of the laser sintered parts. It was found that sintered density increased as the energy density increased reaching a maximum of 80.2% at an energy input per unit volume of 67 J mm-3. For parts produced with a slightly lower power density (50 J mm-3), the microstructure consisted of fine dendrites with interconnected porosity while parts fabricated with a slightly higher power density (100 J mm-3) were noted to have a preponderance of coarse dendrites with a discontinuous network of irregular shaped pores surrounded by a fully dense aluminium-silicon matrix.Mechanical Engineerin

Selective Laser Sintering of Polymer Nanocomposites

This paper describes the fabrication and characterization of polymer nanocomposite (PNC) materials for use in the selective laser sintering (SLS) process. PNC materials are of great interest generally because of their excellent physical properties, and offer excellent potential in rapid manufacturing of structural polymeric parts. Three different nano additive materials have been used: cerium oxide IV, yttrium stabilized zirconia, and layered Hectorite clay. These materials have been used to reinforce PA6 polymer using solution blending and spray drying to create powder with particle sizes in the range of 5-40 µm. The mechanical properties and microstructure of the PNC materials have been evaluated and the results compared to those of unfilled polymer.Mechanical Engineerin

Disappearing galaxies: the orientation dependence of JWST-bright, HST-dark, star-forming galaxy selection

Galaxies that are invisible in deep optical-NIR imaging but detected at longer wavelengths have been the focus of several recent observational studies, with speculation that they could constitute a substantial missing population and even dominate the cosmic star formation rate density at $z\gtrsim4$. The depths now achievable with JWST at the longest wavelengths probed by HST, coupled with the transformative resolution at longer wavelengths, are already enabling detailed, spatially-resolved characterisation of sources that were invisible to HST, often known as `HST-dark' galaxies. However, until now, there has been little theoretical work to compare against. We present the first simulation-based study of this population, using highly-resolved galaxies from the Feedback in Realistic Environments (FIRE) project, with multi-wavelength images along several lines of sight forward-modelled using radiative transfer. We naturally recover a population of modelled sources that meet commonly-used selection criteria ($H_{\rm{AB}}>27\,\rm{mag}$ and $H_{\rm{AB}}-\rm{F444W}>2.3$). These simulated HST-dark galaxies lie at high redshifts ($z=4-7$), have high levels of dust attenuation ($A_{V}=2-4$), and display compact recent star formation ($R_{1/2,\,\rm{4.4\,\mu\rm{m}}}\lesssim1\,\rm{kpc}$). Orientation is very important: for all but one of the 17 simulated galaxy snapshots with HST-dark sightlines, there exist other sightlines that do not meet the criteria. This result has important implications for comparisons between observations and models that do not resolve the detailed star-dust geometry, such as semi-analytic models or coarsely-resolved hydrodynamical simulations. Critically, we demonstrate that HST-dark sources are not an unexpected or exotic population, but a subset of high-redshift, highly-dust-attenuated sources viewed along certain lines of sight.Comment: 12 pages, 8 figures. Accepted for publication in Ap

Macroscopically distinct quantum superposition states as a bosonic code for amplitude damping

We show how macroscopically distinct quantum superposition states (Schroedinger cat states) may be used as logical qubit encodings for the correction of spontaneous emission errors. Spontaneous emission causes a bit flip error which is easily corrected by a standard error correction circuit. The method works arbitrarily well as the distance between the amplitudes of the superposed coherent states increases.Comment: 4 pages, 2 postscript figures, LaTeX2e, RevTeX, minor changes, 1 reference adde

High speed imaging and Fourier analysis of the melt plume during close coupled gas atomisation

A high speed digital analysis technique has been used to study the atomisation plume of a superheated sample of Ni–Al in a close coupled gas atomiser. The atomisation, incorporating a generic melt nozzle and die design was captured using a Kodak high speed digital analyser at a frame rate of 18 k frames per second. The resulting 65 536 frames were then analysed using a specially designed routine, which calculates values of optical brightness and position of the intensity maximum for all frames and performs Fourier analysis on the sequence. The data produced from this analysis show that the plume, pulses at low frequencies (<25 Hz) and precesses at higher frequencies (∼360 Hz) around the atomiser's centreline. To aid investigation into the origins of this precession and other phenomena it was decided to conduct further experiments using an analogue system. The analogue atomiser reproduces the important features of the full atomiser but instead of atomising molten metal, the analogue system atomises water, providing a quick and easy way of testing the effects of changing parameters. Using this system it was found that the precession of the melt plume is independent of the atomiser's gas inlet pressure but strongly dependent on both the die and melt nozzle's geometry

Disease-specific, neurosphere-derived cells as models for brain disorders

There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses. We describe here a new cell model based on patient-derived cells from the human olfactory mucosa, the organ of smell, which regenerates throughout life from neural stem cells. Olfactory mucosa biopsies were obtained from healthy controls and patients with either schizophrenia, a neurodevelopmental psychiatric disorder, or Parkinson's disease, a neurodegenerative disease. Biopsies were dissociated and grown as neurospheres in defined medium. Neurosphere-derived cell lines were grown in serum-containing medium as adherent monolayers and stored frozen. By comparing 42 patient and control cell lines we demonstrated significant disease-specific alterations in gene expression, protein expression and cell function, including dysregulated neurodevelopmental pathways in schizophrenia and dysregulated mitochondrial function, oxidative stress and xenobiotic metabolism in Parkinson's disease. The study has identified new candidate genes and cell pathways for future investigation. Fibroblasts from schizophrenia patients did not show these differences. Olfactory neurosphere-derived cells have many advantages over embryonic stem cells and induced pluripotent stem cells as models for brain diseases. They do not require genetic reprogramming and they can be obtained from adults with complex genetic diseases. They will be useful for understanding disease aetiology, for diagnostics and for drug discovery