ПРЕДИКТИВНОЕ ЗНАЧЕНИЕ МАРКЕРОВ КЛЕТОЧНОГО ЦИКЛА ПРИ РАКЕ СЛИЗИСТОЙ ОБОЛОЧКИ ПОЛОСТИ РТА

The aim of our study was to identify the most significant biological markers characterizing the behavior of the tumor and to forecast its clinical course and to specify an individual therapy regimen for each patient.Работа посвящена выявлению наиболее значимых биологических маркеров клеточного цикла, характеризующих поведение опухоли, с целью прогноза клинического течения опухолевого процесса и индивидуализации схем лечения

Gender-Concealed Concepts in Conceptual Space Languages of Dagestan

The present paper analyzes definitions of the languages of Dagestan with the scope of notions of “the language of men/the language of women”. Many meaningful units of gender are updated within the framework of this classification. The material with a multitude of gender units was dispersed in the conceptual space of Russian and Dagestan languages; however, it was restored by the representation of stereotypes “noun ± adjective”. This allows justifiably to streamline the conceptual space of languages of Dagestan with many interpretations of the surrounding reality. The preference given to the aforementioned classification is because the connotative aspect of nominative units allows for the limination of overlays, i.e. cases of reference of the same interpretations to different terminological headings simultaneously

PROGNOSTIC ROLE OF LABORATORY AND IMMUNOHISTOCHEMICAL MARKERS IN THE RECURRENCE OF ORAL MUCOSAL SQUAMOUS CELL CARCINOMA

Twenty fifty-nine patients with oral mucosal squamous cell carcinoma (a study group) and 50 healthy volunteers (a control group) were followed up. The poor prognosis and occurrence of early recurrences correlated with the simultaneous high level of C-reactive protein (CRP), carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCCA) (and an increase in their values over time), elevated WNC, ACN, and PLT levels, low Caspase-3 expression, high p53 and bcl-2 expression, and the absence of lower Ki-67 expression over time, and the presence of EBV and CMV in tumor tissue. Decreased Ki-67 index at the stages of treatment, high Caspase-3 expression, low bcl-2 and p53 expression, and low CRP, CEA, and SCCA levels, and tumor HPV-positive status were associated with the favorable prognosis of a tumor process