473 research outputs found
Editorial: Sudden Unexpected Death in Epilepsy: Bio-markers, Mechanisms, Risk Identification and Prevention.
Apparatus for timeâresolved measurements of acoustic birefringence in particle dispersions
An apparatus for timeâresolved measurements of the birefringence induced in a particle suspension by an acoustic wave pulse is described. Efficient acoustic coupling is obtained by operating near the transducer resonant frequency and by matching the acoustic impedances of the cell constituents. An almostâoverdamped acoustic configuration can alternatively be employed whenever a faster response is needed. Careful design of the optical setup and of the detection unit minimize diffraction and stressâbirefringence parasitic effects and yields a good responsivity at fairly low acoustic intensities. A test of the apparatus on a colloidal suspension of PTFE rodlike particles is presented and discussed
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Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebo-controlled crossover study.
Backgroundn-3 fatty acids inhibit neuronal excitability and reduce seizures in animal models. High-dose fish oil has been explored in two randomised trials in drug resistant epilepsy with negative results. We performed a phase II randomised controlled crossover trial of low-dose and high-dose fish oil in participants with drug resistant epilepsy to explore whether low-dose or high-dose fish oil reduces seizures or improves cardiovascular health.MethodsRandomised placebo-controlled trial of low-dose and high-dose fish oil versus placebo (corn oil, linoleic acid) in 24 participants with drug resistant epilepsy. A three-period crossover design was utilised lasting 42â
weeks, with three 10-week treatment periods and two 6-week washout periods. All participants were randomised in double-blind fashion to receive placebo, high dose or low dose in different sequences. The primary outcome was per cent change in total seizure frequency.FindingsLow-dose fish oil (3 capsules/day, 1080â
mg eicosapentaenoic acid+docosahexaenoic acid) was associated with a 33.6% reduction in seizure frequency compared with placebo. Low-dose fish oil was also associated with a mild but significant reduction in blood pressure. High-dose fish oil was no different than placebo in reducing seizures or improving cardiac risk factors.InterpretationIn this phase II randomised crossover trial, low-dose fish oil was effective in reducing seizures compared with placebo. The magnitude of improvement is similar to that of recent antiepileptic drug trials in drug resistant epilepsy (DRE). The results indicate that low-dose fish oil may reduce seizures and improve the health of people with epilepsy. These findings justify a large multicentre randomised trial of low-dose fish oil (n-3 fatty acids <1080â
mg/day) in drug resistant epilepsy.Trial registration numberNCT00871377
Polyelectrolyte Persistence Length: Attractive Effect of Counterion Correlations and Fluctuations
The persistence length of a single, strongly charged, stiff polyelectrolyte
chain is investigated theoretically. Path integral formulation is used to
obtain the effective electrostatic interaction between the monomers. We find
significant deviations from the classical Odijk, Skolnick and Fixman (OSF)
result. An induced attraction between monomers is due to thermal fluctuations
and correlations between bound counterions. The electrostatic persistence
length is found to be smaller than the OSF value and indicates a possible
mechanical instability (collapse) for highly charged polyelectrolytes with
multivalent counterions. In addition, we calculate the amount of condensed
counterions on a slightly bent polyelectrolyte. More counterions are found to
be adsorbed as compared to the Manning condensation on a cylinder.Comment: 5 pages, 1 ps figur
Epilepsy Mortality: Leading Causes of Death, Co-morbidities, Cardiovascular Risk and Prevention
a reuptake inhibitor selectively prevents seizure-induced sudden death in the DBA/1 mouse model of sudden unexpected ... Bilateral lesions of the fastigial nucleus prevent the recovery of blood pressure following hypotension induced by ..
Critical Behavior of Hadronic Fluctuations and the Effect of Final-State Randomization
The critical behaviors of quark-hadron phase transition are explored by use
of the Ising model adapted for hadron production. Various measures involving
the fluctuations of the produced hadrons in bins of various sizes are examined
with the aim of quantifying the clustering properties that are universal
features of all critical phenomena. Some of the measures involve wavelet
analysis. Two of the measures are found to exhibit the canonical power-law
behavior near the critical temperature. The effect of final-state randomization
is studied by requiring the produced particles to take random walks in the
transverse plane. It is demonstrated that for the measures considered the
dependence on the randomization process is weak. Since temperature is not a
directly measurable variable, the average hadronic density of a portion of each
event is used as the control variable that is measurable. The event-to-event
fluctuations are taken into account in the study of the dependence of the
chosen measures on that control variable. Phenomenologically verifiable
critical behaviors are found and are proposed for use as a signature of
quark-hadron phase transition in relativistic heavy-ion collisions.Comment: 17 pages (Latex) + 24 figures (ps file), submitted to Phys. Rev.
Baylisascaris procyonis: An Emerging Helminthic Zoonosis
Baylisascaris procyonis, a roundworm infection of raccoons, is emerging as an important helminthic zoonosis, principally affecting young children. Raccoons have increasingly become peridomestic animals living in close proximity to human residences. When B. procyonis eggs are ingested by a host other than a raccoon, migration of larvae through tissue, termed larval migrans, ensues. This larval infection can invade the brain and eye, causing severe disease and death. The prevalence of B. procyonis infection in raccoons is often high, and infected animals can shed enormous numbers of eggs in their feces. These eggs can survive in the environment for extended periods of time, and the infectious dose of B. procyonis is relatively low. Therefore, the risk for human exposure and infection may be greater than is currently recognized
Turning light into a liquid via atomic coherence
We study a four level atomic system with electromagnetically induced
transparency with giant and susceptibilities of
opposite signs. This system would allow to obtain multidimensional solitons and
light condensates with surface tension properties analogous to those of usual
liquids
Self-diffusion coefficients of charged particles: Prediction of Nonlinear volume fraction dependence
We report on calculations of the translational and rotational short-time
self-diffusion coefficients and for suspensions of
charge-stabilized colloidal spheres. These diffusion coefficients are affected
by electrostatic forces and many-body hydrodynamic interactions (HI). Our
computations account for both two-body and three-body HI. For strongly charged
particles, we predict interesting nonlinear scaling relations and depending on volume fraction
, with essentially charge-independent parameters and . These
scaling relations are strikingly different from the corresponding results for
hard spheres. Our numerical results can be explained using a model of effective
hard spheres. Moreover, we perceptibly improve the known result for of
hard sphere suspensions.Comment: 8 pages, LaTeX, 3 Postscript figures included using eps
Relationship between dielectric properties and critical behavior of the electric birefringence in binary liquid mixtures
We present experimental results on the critical exponent ÏEKE describing the divergence of the Kerr constant of binary liquid mixtures near the critical consolute point. We show that the measured value of ÏEKE agrees with the theoretical prediction only if the measurement is performed with a mixture of two liquids presenting a small mismatch in the dielectric constant, and that the measured ÏEKE grows as the dielectric constant mismatch increases. Such findings are consistent with a recent model which assumes that the elongation of critical fluctations along the direction of the electric field can become so strong that fluctuations in the direction perpendicular to the electric field may cross over from Ising to mean-field behavior
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