A field-extrema hysteresis loss model for high-frequency ferrimagnetic materials

We present a new field-extrema hysteresis loss model (FHM) for high-frequency ferrimagnetic materials, along with a parameter identification procedure. The model does not involve solving an ordinary differential equation (ODE) and is asymmetric in that it works well under dc bias conditions. In the proposed model, the loss calculations are based on the extrema values of the fields. The model includes the effects of magnetic saturation as well as frequency effects. The model is comparable in accuracy to the ODE-based Jiles-Atherton model, but retains the convenience and computational efficiency of an empirical model. We demonstrate a procedure to characterize the model parameters using the Jiles-Atherton model. We compare magnetic hysteresis loss calculated by our new model with a full time-domain solution, as well as an empirical model, for a sample high-frequency ferrite. We demonstrate the use of the model, and validate the model, by calculating magnetic loss in an EI core inductor operating as the filter inductor in a buck converter. The model and identification procedure are being endorsed as a useful framework for computing magnetic loss in the context of automated magnetic device design

Aboriginal Resource Access in Response to Criminal Victimization in an Urban Context

Arts, Education and LawNo Full Tex

Having their say: Young people on healthy, active lifestyles

Having their say: Young people on healthy, active lifestyle

New Design for Prefilled Syringe

Prefilled syringes are currently available as treatment options for individuals with diabetes, allergies, and other medical conditions mandating delivery of drugs by injection. However current prefilled syringes are often bulky, conspicuous, require specific storage conditions, and may prematurely deploy. Because of these factors, patients may be less compliant to treatment regimens and feel that their lifestyles and independence are inhibited. The newly designed prefilled syringe should be portable, practical, and easy-to-use. This project will be completed for Bionix Corporation located in Toledo, OH. Our contacts at this company are Mr. Ed Markewitz, Product Development Program Manager, and Mr. Cody Harder, Product Development Engineer. Cody Harder has served as our main contact throughout the duration of the project. The purpose of this project is to develop a prefilled syringe for Bionix that competes with currently available syringes. Currently, Bionix has no such product, as they mainly specialize in radiation therapy equipment. Bionix also has a Medical Technologies division that makes disposable medical instruments, and Bionix is looking for a syringe product that it may sell and distribute to drug companies. Through the design of the new prefilled syringe, Stringent Syringes intends to improve the quality of existing products from a patient perspective my enhancing ease of use and making the syringe less conspicuous than existing products. Stringent Syringes has completed this project by designing a compact and user-friendly prefilled syringe using a folding plunger to reduce the overall size of the device. The newly designed syringe is portable, able to withstand considerable mechanical forces, and meets the criteria established in the literature by users of prefilled syringes

Noncompleted Sexual Offenses: Internal States, Risks and Difficulties Related to Crime Commission through the Lens of Sexual Offenders

The study aims to generate insights from sexual offenders on the influence of internal states and how they perceive risks of apprehension and difficulties in the context of noncompleted sexual offenses, that is when offenders initiated the offense but were stopped or discouraged either before or during sexual contact. Adult males incarcerated for sexually offending completed a self-report questionnaire. Regression models, including interaction effects, were estimated. Two interaction effects were found providing insights into which and how internal states, such as intoxication to alcohol, may influence perceived difficulties related to crime. Future research should promote the investigation of noncompleted sexual offenses, which could provide a real opportunity to generate new or complementary insights for better understanding and guiding prevention initiatives

Effect of the Synthetic Bile Salt Analog CamSA on the Hamster Model of Clostridium difficile Infection

Clostridium difficile infection (CDI) is the leading cause of antibiotic-associated diarrhea and has gained worldwide notoriety due to emerging hypervirulent strains and the high incidence of recurrence. We previously reported protection of mice from CDI using the antigerminant bile salt analog CamSA. Here we describe the effects of CamSA in the hamster model of CDI. CamSA treatment of hamsters showed no toxicity and did not affect the richness or diversity of gut microbiota; however, minor changes in community composition were observed. Treatment of C. difficile-challenged hamsters with CamSA doubled the mean time to death, compared to control hamsters. However, CamSA alone was insufficient to prevent CDI in hamsters. CamSA in conjunction with suboptimal concentrations of vancomycin led to complete protection from CDI in 70% of animals. Protected animals remained disease-free at least 30 days postchallenge and showed no signs of colonic tissue damage. In a delayed-treatment model of hamster CDI, CamSA was unable to prevent infection signs and death. These data support a putative model in which CamSA reduces the number of germinating C. difficile spores but does not keep all of the spores from germinating. Vancomycin halts division of any vegetative cells that are able to grow from spores that escape CamSA

Characterization of Soil Water Content Variability and Soil Texture Using GPR Groundwave Techniques

Accurate characterization of near-surface soil water content is vital for guiding agricultural management decisions and for reducing the potential negative environmental impacts of agriculture. Characterizing the near-surface soil water content can be difficult, as this parameter is often both spatially and temporally variable, and obtaining sufficient measurements to describe the heterogeneity can be prohibitively expensive. Understanding the spatial correlation of near-surface soil water content can help optimize data acquisition and improve understanding of the processes controlling soil water content at the field scale. In this study, ground penetrating radar (GPR) methods were used to characterize the spatial correlation of water content in a three acre field as a function of sampling depth, season, vegetation, and soil texture. GPR data were acquired with 450 MHz and 900 MHz antennas, and measurements of the GPR groundwave were used to estimate soil water content at four different times. Additional water content estimates were obtained using time domain reflectometry measurements, and soil texture measurements were also acquired. Variograms were calculated for each set of measurements, and comparison of these variograms showed that the horizontal spatial correlation was greater for deeper water content measurements than for shallower measurements. Precipitation and irrigation were both shown to increase the spatial variability of water content, while shallowly-rooted vegetation decreased the variability. Comparison of the variograms of water content and soil texture showed that soil texture generally had greater small-scale spatial correlation than water content, and that the variability of water content in deeper soil layers was more closely correlated to soil texture than were shallower water content measurements. Lastly, cross-variograms of soil texture and water content were calculated, and co-kriging of water content estimates and soil texture measurements showed that geophysically-derived estimates of soil water content could be used to improve spatial estimation of soil texture

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission

Defects of mitochondrial dynamics are emerging causes of neurological disease. In two children presenting with severe neurological deterioration following viral infection we identified a novel homozygous STAT2 mutation, c.1836C4A (p.Cys612Ter), using whole exome sequencing. In muscle and fibroblasts from these patients, and a third unrelated STAT2-deficient patient, we observed extremely elongated mitochondria. Western blot analysis revealed absence of the STAT2 protein and that the mitochondrial fission protein DRP1 (encoded by DNM1L) is inactive, as shown by its phosphorylation state. All three patients harboured 15 decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1S616), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1S637), associated with the inactive state of the DRP1 GTPase. Knockdown of STAT2 in SHSY5Y cells recapitulated the fission defect, with elongated mitochondria and decreased PDRP1 S616 levels. Furthermore the mitochondrial fission defect in patient fibroblasts was rescued following lentiviral transduction with wild-type STAT2 in all three patients, with normalization of mitochondrial length and increased P-DRP1S616 levels. Taken 20 together, these findings implicate STAT2 as a novel regulator of DRP1 phosphorylation at serine 616, and thus of mitochondrial fission, and suggest that there are interactions between immunity and mitochondria. This is the first study to link the innate immune system to mitochondrial dynamics and morphology. We hypothesize that variability in JAK-STAT signalling may contribute to the phenotypic heterogeneity of mitochondrial disease, and may explain why some patients with underlying mitochondrial disease decompensate after seemingly trivial viral infections. Modulating JAK-STAT activity may represent a novel 25 therapeutic avenue for mitochondrial diseases, which remain largely untreatable. This may also be relevant for more common neurodegenerative diseases, including Alzheimer’s, Huntington’s and Parkinson’s diseases, in which abnormalities of mitochondrial morphology have been implicated in disease pathogenesis

TOI-431/HIP 26013: A super-Earth and a sub-Neptune transiting a bright, early K dwarf, with a third RV planet

We present the bright (Vmag = 9.12), multiplanet system TOI-431, characterized with photometry and radial velocities (RVs). We estimate the stellar rotation period to be 30.5 \ub1 0.7 d using archival photometry and RVs. Transiting Exoplanet Survey Satellite (TESS) objects of Interest (TOI)-431 b is\ua0a\ua0super-Earth with\ua0a\ua0period of 0.49 d,\ua0a\ua0radius of 1.28 \ub1 0.04 R,\ua0a\ua0mass of 3.07 \ub1 0.35 M, and\ua0a\ua0density of 8.0 \ub1 1.0 g cm-3; TOI-431 d is\ua0a\ua0sub-Neptune with\ua0a\ua0period of 12.46 d,\ua0a\ua0radius of 3.29 \ub1 0.09 R,\ua0a\ua0mass of 9.90+1.53-1.49 M, and\ua0a\ua0density of 1.36 \ub1 0.25 g cm-3. We find\ua0a\ua0third planet, TOI-431 c,\ua0in\ua0the High Accuracy Radial velocity Planet Searcher RV data, but it is not seen to transit\ua0in\ua0the TESS light curves. It has an Msin i of 2.83+0.41-0.34 M, and\ua0a\ua0period of 4.85 d. TOI-431 d likely has an extended atmosphere and is one of the most well-suited TESS discoveries for atmospheric characterization, while the super-Earth TOI-431 b may be\ua0a\ua0stripped core. These planets straddle the radius gap, presenting an interesting case-study for atmospheric evolution, and TOI-431 b is\ua0a\ua0prime TESS discovery for the study of rocky planet phase curves