Calorimeter measures high nuclear heating rates and their gradients across a reactor test hole

Pedestal-type calorimeter measures gamma-ray heating rates from 0.5 to 7.0 watts per gram of aluminum. Nuclear heating rate is a function of cylinder temperature change, measured by four chromel-alumel thermocouples attached to the calorimeter, and known thermoconductivity of the tested material

Nutrient concentrations and accumulations in precipitation over the north central region

The many facets of plant nutrients (e.g., N, P, and S) in the biosphere have become major environmental issues within the past decade. This concern is justified because of the increasing contamination of air and water resources by various substances on local and regional levels, especially in areas close to point sources. Little information is available, however, on variation in the amounts and concentrations of some of the substances present in air and natural water in various parts of the United States. Such information is essential for a better understanding of the transport and perhaps the fates of pollutants in the biosphere. The atmospheric component of the N and S cycles often can be a significant part of the various pools of their respective cycles (Allison, 1965; Erickson, 1963; Feth, 1966; Gambell and Fisher, 1964; Meetham, 1950; Robinson and Robbins, 1970), but the atmospheric component of the P cycle seems to be of minor significance to the cycling of this element in the environment. Among the various chemical elements present in precipitation (e.g., N, S, K, Cl, and Ca), N and S deserve special attention because N added by precipitation may contribute to nitrate pollution of surface and ground water. Sulfur and N may cause acid rain that can lead to increased leaching from soils of Ca and other nutrient elements, deterioration of aquatic ecosystems, damage to vegetation and buildings, and other agricultural and urban problems. On the other hand, the limited amounts of N and S brought down by precipitation might be useful to meet crop requirements for these elements in areas where soils have limited supplies of N and S (Allway et al., 1937; Erdman, 1923; Olson et al., 1973; Schuman and Burwell, 1974; Tabatabai and Bremner, 1972; Walker, 1969; Widdowson and Hanway, 1974)

Prevalence of and variables associated with silent myocardial ischemia on exercise thallium-201 stress testing

AbstractThe prevalence of silent myocardial ischemia was prospectively assessed in a group of 103 consecutive patients (mean age 59 ± 10 years, 79% male) undergoing symptom-limited exercise thallium-201 scintigraphy. Variables that best correlated with the occurance of patients ischemia by quantitative scintigraphic criteria were examined. Fifty-nine patients (57%) had no angina on exercise testing. A significantly greater persent of patients with silent ischemia than of patients with angina had a recent myocardial infarction (31% versus 7%, P < 0.01), had no prior angina (91% versus 64%, p < 0.01), had dyspnea as an exercise test end point (56% versus 35%, p < 0.05) and exhibited redistribution defects in the supply regions of the right and circumflex coronary arteries (50% versus 35%, p < 0.05). The group with exercise angina had more ST depression (64% versus 41%, p < 0.05) and more patients with four or more redistribution defects.However, there was no difference between the two groups with respect to mean total thallium-201 perfusion score, number of redistribution defects per patient, multivessel thallium redistribution pattern or extent of angiographic coronary artery disease. There was also no difference between the silent ischemia and angina groups with respect to antianginal drug, usage, prevalence of diabetes mellitus, exercise duration, peak exercise heart rate, peak work load, peak double (rate-pressure) product and percent of patients achieving ≥85% of maximal predicted heart rate for age.Thus, in this study group, there was a rather high prevalence rate of silent ischemia (57%) by exercise thallium-201 criteria. Patients with silent ischemia and those with exercise angina had comparable 1) exercise tolerance and hemodynamics, 2) extent of angiographic coronary artery disease, and 3) extent of exercise-induced hypoperfusion. Finally, more patients with recent infarction had silent ischemia than had exercise angina

Adolescent idiopathic scoliosis (AIS), environment, exposome and epigenetics: a molecular perspective of postnatal normal spinal growth and the etiopathogenesis of AIS with consideration of a network approach and possible implications for medical therapy

Genetic factors are believed to play an important role in the etiology of adolescent idiopathic scoliosis (AIS). Discordant findings for monozygotic (MZ) twins with AIS show that environmental factors including different intrauterine environments are important in etiology, but what these environmental factors may be is unknown. Recent evidence for common chronic non-communicable diseases suggests epigenetic differences may underlie MZ twin discordance, and be the link between environmental factors and phenotypic differences. DNA methylation is one important epigenetic mechanism operating at the interface between genome and environment to regulate phenotypic plasticity with a complex regulation across the genome during the first decade of life. The word exposome refers to the totality of environmental exposures from conception onwards, comprising factors in external and internal environments. The word exposome is used here also in relation to physiologic and etiopathogenetic factors that affect normal spinal growth and may induce the deformity of AIS. In normal postnatal spinal growth we propose a new term and concept, physiologic growth-plate exposome for the normal processes particularly of the internal environments that may have epigenetic effects on growth plates of vertebrae. In AIS, we propose a new term and concept pathophysiologic scoliogenic exposome for the abnormal processes in molecular pathways particularly of the internal environment currently expressed as etiopathogenetic hypotheses; these are suggested to have deforming effects on the growth plates of vertebrae at cell, tissue, structure and/or organ levels that are considered to be epigenetic. New research is required for chromatin modifications including DNA methylation in AIS subjects and vertebral growth plates excised at surgery. In addition, consideration is needed for a possible network approach to etiopathogenesis by constructing AIS diseasomes. These approaches may lead through screening, genetic, epigenetic, biochemical, metabolic phenotypes and pharmacogenomic research to identify susceptible individuals at risk and modulate abnormal molecular pathways of AIS. The potential of epigenetic-based medical therapy for AIS cannot be assessed at present, and must await new research derived from the evaluation of epigenetic concepts of spinal growth in health and deformity. The tenets outlined here for AIS are applicable to other musculoskeletal growth disorders including infantile and juvenile idiopathic scoliosis

The Communication Patterns Questionnaire-Short Form: A Review and Assessment

The Communication Patterns Questionnaire-Short Form (CPQ-SF) is an 11-item self-assessment of spouses’ perceptions of marital interactions. A cited reference review of the CPQ-SF literature revealed no formal assessment of its psychometric properties and that researchers are imprecise in their use, reporting, and referencing of the assessment. Toward improving the use of the CPQ-SF in research and practice, the factor structure and psychometric properties of this scale were examined with data collected from a diverse sample of married individuals. Three latent constructs were identified: criticize/defend, discuss/avoid, and positive interaction patterns. Support for the original two-factor structure, demand/withdrawal and positive interaction, was also found. Suggestions for a more precise use of the CPQ-SF in research and practice conclude the paper

Relatively lower body mass index is associated with an excess of severe truncal asymmetry in healthy adolescents: Do white adipose tissue, leptin, hypothalamus and sympathetic nervous system influence truncal growth asymmetry?

<p>Abstract</p> <p>Background</p> <p>In healthy adolescents normal back shape asymmetry, here termed truncal asymmetry (TA), is evaluated by higher and lower subsets of BMI. The study was initiated after research on girls with adolescent idiopathic scoliosis (AIS) showed that higher and lower BMI subsets discriminated patterns of skeletal maturation and asymmetry unexplained by existing theories of pathogenesis leading to a new interpretation which has therapeutic implications <it>(double neuro-osseous theory)</it>.</p> <p>Methods</p> <p>5953 adolescents age 11–17 years (boys 2939, girls 3014) were examined in a school screening program in two standard positions, standing forward bending (FB) and sitting FB. The sitting FB position is thought to reveal intrinsic TA free from back humps induced by any leg-length inequality. TA was measured in both positions using a Pruijs scoliometer as angle of trunk inclinations (ATIs) across the back at each of three spinal regions, thoracic, thoracolumbar and lumbar. Abnormality of ATIs was defined as being outside 2 standard deviations for each age group, gender, position and spinal region, and termed <it>severe </it>TA.</p> <p>Results</p> <p>In the sitting FB position after correcting for age,<it>relatively lower BMIs </it>are statistically associated with a greater number of severe TAs than with relatively higher BMIs in both girls (thoracolumbar region) and boys (thoracolumbar and lumbar regions).</p> <p>The relative frequency of severe TAs is significantly higher in girls than boys for each of the right thoracic (56.76%) and thoracolumbar (58.82%) regions (p = 0.006, 0.006, respectively). After correcting for age, smaller BMIs are associated with more <it>severe TAs </it>in boys and girls.</p> <p>Discussion</p> <p>BMI is a surrogate measure for body fat and circulating leptin levels. The finding that girls with relatively lower BMI have significantly later menarche, and a significant excess of TAs, suggests a relation to energy homeostasis through the hypothalamus. The hypothesis we suggest for the pathogenesis of severe TA in girls and boys has the same mechanism as that proposed recently for AIS girls, namely: severe TAs are initiated by a <it>genetically-determined selectively </it>increased hypothalamic sensitivity (up-regulation, i.e. increased sensitivity) to leptin with asymmetry as an adverse response to stress (hormesis), mediated bilaterally mainly to the growing trunk via the sympathetic nervous system <it>(leptin-hypothalamic-sympathetic nervous system (LHS) concept)</it>. The putative autonomic dysfunction is thought to be increased by any lower circulating leptin levels associated with relatively lower BMIs. Sympathetic nervous system activation with asymmetry leads to asymmetries in ribs and/or vertebrae producing severe TA when beyond the capacity of postural mechanisms of the somatic nervous system to control the shape distortion of the trunk. A test of this hypothesis testing skin sympathetic responses, as in the Rett syndrome, is suggested.</p

"Rehabilitation schools for scoliosis" thematic series: describing the methods and results

The Scoliosis Rehabilitation model begins with the correct diagnosis and evaluation of the patient, to make treatment decisions oriented to the patient. The treatment is based on observation, education, scoliosis specific exercises, and bracing. The state of research in the field of conservative treatment is insufficient. There is some evidence supporting scoliosis specific exercises as a part of the rehabilitation treatment, however, the evidence is poor and the different methods are not known by most of the scientific community. The only way to improve the knowledge and understanding of the different physiotherapy methodologies (specific exercises), integrated into the whole rehabilitation program, is to establish a single and comprehensive source of information about it. This is what the SCOLIOSIS Journal is going to do through the "Rehabilitation Schools for Scoliosis" Thematic Series, where technical papers coming from the different schools will be published

Pathogenesis of adolescent idiopathic scoliosis in girls - a double neuro-osseous theory involving disharmony between two nervous systems, somatic and autonomic expressed in the spine and trunk: possible dependency on sympathetic nervous system and hormones with implications for medical therapy

Anthropometric data from three groups of adolescent girls - preoperative adolescent idiopathic scoliosis (AIS), screened for scoliosis and normals were analysed by comparing skeletal data between higher and lower body mass index subsets. Unexpected findings for each of skeletal maturation, asymmetries and overgrowth are not explained by prevailing theories of AIS pathogenesis. A speculative pathogenetic theory for girls is formulated after surveying evidence including: (1) the thoracospinal concept for right thoracic AIS in girls; (2) the new neuroskeletal biology relating the sympathetic nervous system to bone formation/resorption and bone growth; (3) white adipose tissue storing triglycerides and the adiposity hormone leptin which functions as satiety hormone and sentinel of energy balance to the hypothalamus for long-term adiposity; and (4) central leptin resistance in obesity and possibly in healthy females. The new theory states that AIS in girls results from developmental disharmony expressed in spine and trunk between autonomic and somatic nervous systems. The autonomic component of this double neuro-osseous theory for AIS pathogenesis in girls involves selectively increased sensitivity of the hypothalamus to circulating leptin (genetically-determined up-regulation possibly involving inhibitory or sensitizing intracellular molecules, such as SOC3, PTP-1B and SH2B1 respectively), with asymmetry as an adverse response (hormesis); this asymmetry is routed bilaterally via the sympathetic nervous system to the growing axial skeleton where it may initiate the scoliosis deformity (leptin-hypothalamic-sympathetic nervous system concept = LHS concept). In some younger preoperative AIS girls, the hypothalamic up-regulation to circulating leptin also involves the somatotropic (growth hormone/IGF) axis which exaggerates the sympathetically-induced asymmetric skeletal effects and contributes to curve progression, a concept with therapeutic implications. In the somatic nervous system, dysfunction of a postural mechanism involving the CNS body schema fails to control, or may induce, the spinal deformity of AIS in girls (escalator concept). Biomechanical factors affecting ribs and/or vertebrae and spinal cord during growth may localize AIS to the thoracic spine and contribute to sagittal spinal shape alterations. The developmental disharmony in spine and trunk is compounded by any osteopenia, biomechanical spinal growth modulation, disc degeneration and platelet calmodulin dysfunction. Methods for testing the theory are outlined. Implications are discussed for neuroendocrine dysfunctions, osteopontin, sympathoactivation, medical therapy, Rett and Prader-Willi syndromes, infantile idiopathic scoliosis, and human evolution. AIS pathogenesis in girls is predicated on two putative normal mechanisms involved in trunk growth, each acquired in evolution and unique to humans

Low Pressure Negative Ion Drift Chamber for Dark Matter Search

Weakly Interacting Massive Particles (WIMPs) are an attractive candidate for the dark matter thought to make up the bulk of the mass of our universe. We explore here the possibility of using a low pressure negative ion drift chamber to search for WIMPs. The innovation of drifting ions, instead of electrons, allows the design of a detector with exceptional sensitivity to, background rejection from, and signature of WIMPs.Comment: 5 pages submitted to PR

Elevational sensitivity in an Asian 'hotspot': Moth diversity across elevational gradients in tropical, sub-tropical and sub-alpine China

South-western China is widely acknowledged as a biodiversity 'hotspot': there are high levels of diversity and endemism, and many environments are under significant anthropogenic threats not least climate warming. Here, we explore diversity and compare response patterns of moth assemblages among three elevational gradients established within different climatic bioregions - tropical rain forest, sub-tropical evergreen broad-leaved forest and sub-alpine coniferous forest in Yunnan Province, China. We hypothesised that tropical assemblages would be more elevationally stratified than temperate assemblages, and tropical species would be more elevationally restricted than those in the temperate zone. Contrary to our hypothesis, the moth fauna was more sensitive to elevational differences within the temperate transect, followed by sub-tropical and tropical transects. Moths in the cooler and more seasonal temperate sub-alpine gradient showed stronger elevation-decay beta diversity patterns, and more species were restricted to particular elevational ranges. Our study suggests that moth assemblages are under threat from future climate change and sub-alpine rather than tropical faunas may be the most sensitive to climate change. These results improve our understanding of China's biodiversity and can be used to monitor future changes to herbivore assemblages in a 'hotspot' of biodiversity.Link_to_subscribed_fulltex