Beneficial Effects of Ceftriaxone Against Pentylenetetrazole-Evoked Convulsions

Although considered to be generally safe, a number of P-lactam antibiotics have been associated with epileptic seizures in humans. Furthermore, some P-lactam antibiotics, including ceftriaxone, are used to evoke convulsions under experimental conditions. Recently it was demonstrated that ceftriaxone increased expression of the glutamate transporter (GLT1) and its biochemical and functional activity in the brain of rodents. GLT1 regulates extracellular concentrations of glutamate, an excitatory amino acid involved in the pathogenesis of seizures and epilepsy. Because of its rapid transfer of glutamate into neurons and adjacent glial cells, GLT1 diminishes glutamate toxicity. We investigated whether ceftriaxone (200 mg/kg body wt) administered intraperitoneally (ip) for 6 days could modify the convulsant effects of pentylenetetrazole (PTZ, 100 mg/kg ip) in inbred male BALBcAnNCR and C57 black (BL)/6 mice aged 4 and 12 weeks. Ceftriaxone pretreatment provided significant protective effects against PTZ-evoked generalized clonic convulsions (GCCs), generalized clonic-tonic convulsions (GCTCs), and convulsion-induced mortality during a period of 30 mins after PTZ administration. The incidence of GCCs, GCTCs, and death was statistically significantly lower for BALBcAnNCR mice of both ages, particularly younger mice. The latency time for each of the three parameters was significantly greater, with the exception of GCCs in adult mice. Protective effects of ceftriaxone were also noticed in adult C57BL/6 mice but not in prepubertal C57BL/6 mice. This is the first demonstration of anticonvulsant effects of ceftriaxone or any other P-lactam antibiotic, which are not uniform across the mouse population. Our results provide new insight into the effects of ceftriaxone, which need further investigation. Exp Biol Med 233:1389-1394, 2008Ministry or Science of the Republic of Serbia [143057

Public Space in Late Antique Ostia: Excavation and Survey by the University of Kent 2008-2011

This article presents the work of the University of Kent section of the Late Antique Ostia Project, which since 2008 has studied the evolution of public space in the central area of the city, in conjunction with the Humboldt University of Berlin. This research has sought to detect and document Late Antique remains within a clearance-excavated classical site using minimally invasive methods. It has demonstrated that Ostia saw a level of investment in secular public buildings that surpassed other cities in Italy outside of Rome. Thus, Russell Meiggs' view that the construction of Portus led to the demise of Ostia, in terms of its political and economic vitality, now seems unlikely. Until the mid fifth century, Ostia was still significant as a center of political representation that followed the urban fashions of the age, which now came from the eastern Mediterranean rather than from Rome. English summaries of the work of the Berlin team are provided by its director, Axel Gering; that work is published in greater detail in a parallel report in Römische Mitteilungen