369 research outputs found
Large Binocular Telescope view of the atmosphere of GJ1214b
The atmospheric composition and vertical structure of the super-Earth GJ1214b
has been a subject of debate since its discovery in 2009. Recent studies have
indicated that high-altitude clouds might mask the lower layers. However, some
data points that were gathered at different times and facilities do not fit
this picture, probably because of a combination of stellar activity and
systematic errors. We observed two transits of GJ1214b with the Large Binocular
Camera, the dual-channel camera at the Large Binocular Telescope. For the first
time, we simultaneously measured the relative planetary radius
at blue and red optical wavelengths (), thus
constraining the Rayleigh scattering on GJ1214b after correcting for stellar
activity effects. To the same purpose, a long-term photometric follow-up of the
host star was carried out with WiFSIP at STELLA, revealing a rotational period
that is significantly longer than previously reported. Our new unbiased
estimates of yield a flat transmission spectrum extending to shorter
wavelengths, thus confirming the cloudy atmosphere scenario for GJ1214b.Comment: 11 pages, 5 figures, 3 tables. Published in A&A. Minor changes to
reflect the published versio
Activation of NF-kappaB/Rel transcription factors in human primary peripheral blood mononuclear cells by interleukin 7.
Pathways that regulate the activation of NF-kappaB/Rel transcription factors are known to include signaling through a number of cytokine receptors. Interleukin 7 (IL-7), produced by bone marrow and other stromal cells, is a key factor for differentiation and survival in the lymphoid and other compartments. We found that human recombinant IL-7 induced NF-kappaB/Rel activation, analyzed by electrophoretic mobility shift assay (EMSA), in human peripheral blood T lymphocytes from healthy donors. Induced complexes included p65 and p50 NF-kappaB/Rel subunits. These results demonstrate for the first time that IL-7 can participate in signaling leading to NF-kappaB/Rel activation
Practice Recommendations for Diagnosis and Treatment of the Most Common Forms of Secondary Hypertension
The vast majority of hypertensive patients are never sought for a cause of their high blood pressure, i.e. for a \u2018secondary\u2019 form of arterial hypertension. This under detection explains why only a tiny percentage of hypertensive patients are ultimately diagnosed with a secondary form of arterial hypertension. The prevalence of these forms is, therefore, markedly underestimated, although, they can involve as many as one-third of the cases among referred patients and up to half of those with difficult to treat hypertension. The early detection of a secondary form is crucial, because if diagnosed in a timely manner, these forms can be cured at long-term, and even when cure cannot be achieved, their diagnosis provides a better control of high blood pressure, and allows prevention of hypertension-mediated organ damage, and related cardiovascular complications. Enormous progress has been made in the understanding, diagnostic\ua0work-up, and management of secondary hypertension in the last decades. The\ua0aim of this minireview is, therefore, to provide updated concise information on the screening, diagnosis, and management of the most common forms, including primary aldosteronism, renovascular hypertension, pheochromocytoma and paraganglioma, Cushing\u2019s syndrome, and obstructive sleep apnea
Analysis of time-profiles with in-beam PET monitoring in charged particle therapy
Background: Treatment verification with PET imaging in charged particle
therapy is conventionally done by comparing measurements of spatial
distributions with Monte Carlo (MC) predictions. However, decay curves can
provide additional independent information about the treatment and the
irradiated tissue. Most studies performed so far focus on long time intervals.
Here we investigate the reliability of MC predictions of space and time (decay
rate) profiles shortly after irradiation, and we show how the decay rates can
give an indication about the elements of which the phantom is made up.
Methods and Materials: Various phantoms were irradiated in clinical and
near-clinical conditions at the Cyclotron Centre of the Bronowice proton
therapy centre. PET data were acquired with a planar 16x16 cm PET system.
MC simulations of particle interactions and photon propagation in the phantoms
were performed using the FLUKA code. The analysis included a comparison between
experimental data and MC simulations of space and time profiles, as well as a
fitting procedure to obtain the various isotope contributions in the phantoms.
Results and conclusions: There was a good agreement between data and MC
predictions in 1-dimensional space and decay rate distributions. The fractions
of C, O and C that were obtained by fitting the decay
rates with multiple simple exponentials generally agreed well with the MC
expectations. We found a small excess of C in data compared to what was
predicted in MC, which was clear especially in the PE phantom.Comment: 9 pages, 5 figures, 1 table. Proceedings of the 20th International
Workshop on Radiation Imaging Detectors (iWorid2018), 24-28 June 2018,
Sundsvall, Swede
Femtosecond Dynamics of Momentum-Dependent Magnetic Excitations from Resonant Inelastic X-Ray Scattering in CaCu<sub>2</sub>O<sub>3</sub>
Taking spinon excitations in the quantum antiferromagnet CaCu2O3 as an example, we demonstrate that femtosecond dynamics of magnetic electronic excitations can be probed by direct resonant inelastic x-ray scattering (RIXS). To this end, we isolate the contributions of single and double spin-flip excitations in experimental RIXS spectra, identify the physical mechanisms that cause them, and determine their respective time scales. By comparing theory and experiment, we find that double spin flips need a finite amount of time to be generated, rendering them sensitive to the core-hole lifetime, whereas single spin flips are, to a very good approximation, independent of it. This shows that RIXS can grant access to time-domain dynamics of excitations and illustrates how RIXS experiments can distinguish between excitations in correlated electron systems based on their different time dependence
Electronic character of charge order in square planar low valence nickelates
Charge order is a central feature of the physics of cuprate superconductors
and is known to arise from a modulation of holes with primarily oxygen
character. Low-valence nickelate superconductors also host charge order, but
the electronic character of this symmetry breaking is unsettled. Here, using
resonant inelastic x-ray scattering at the Ni -edge, we identify
intertwined involvements of Ni , , and O
orbitals in the formation of diagonal charge order in an
overdoped low-valence nickelate LaNiO. The Ni
orbitals, strongly hybridized with planar O , largely shape the
spatial charge distribution and lead to Ni site-centered charge order. The
orbitals play a small, but non-negligible role in the charge
order as they hybridize with the rare-earth orbitals. Our results reveal
that the low-energy physics and ground-state character of these nickelates are
more complex than those in cuprates.Comment: Accepted in Physical Review X; 7 pages plus references and
supplementary material
Resonant inelastic x-ray scattering data for Ruddlesden-Popper and reduced Ruddlesden-Popper nickelates
Ruddlesden-Popper and reduced Ruddlesden-Popper nickelates are intriguing
candidates for mimicking the properties of high-temperature superconducting
cuprates. The degree of similarity between these nickelates and cuprates has
been the subject of considerable debate. Resonant inelastic x-ray scattering
(RIXS) has played an important role in exploring their electronic and magnetic
excitations, but these efforts have been stymied by inconsistencies between
different samples and the lack of publicly available data for detailed
comparison. To address this issue, we present open RIXS data on La4Ni3O10 and
La4Ni3O8.Comment: Data descriptor article; accepted in Scientific Data; 8 pages; 6
figure
Full-beam performances of a PET detector with synchrotron therapeutic proton beams
Treatment quality assessment is a crucial feature for both present and nextgeneration ion therapy facilities. Several approaches are being explored, based on prompt radiation emission or on PET signals by β+;-decaying isotopes generated by beam interactions with the body. In-beam PET monitoring at synchrotron-based ion therapy facilities has already been performed, either based on inter-spill data only, to avoid the influence of the prompt radiation, or including both in-spill and inter-spill data. However, the PET images either suffer of poor statistics (inter-spill) or are more influenced by the background induced by prompt radiation (in-spill). Both those problems are expected to worsen for accelerators with improved duty cycle where the inter-spill interval is reduced to shorten the treatment time. With the aim of assessing the detector performance and developing techniques for background reduction, a test of an in-beam PET detector prototype was performed at the CNAO synchrotron-based ion therapy facility in full-beam acquisition modality. Data taken with proton beams impinging on PMMA phantoms showed the system acquisition capability and the resulting activity distribution, separately reconstructed for the in-spill and the inter-spill data. The coincidence time resolution for in-spill and inter-spill data shows a good agreement, with a slight deterioration during the spill. The data selection technique allows the identification and rejection of most of the background originated during the beam delivery. The activity range difference between two different proton beam energies (68 and 72 MeV) was measured and found to be in submillimeter agreement with the expected result. However, a slightly longer (2 mm) absolute profile length is obtained for in-spill data when compared to inter-spill data
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