Radiocarbon dates from the Oxford AMS system: archaeometry datelist 35

This is the 35th list of AMS radiocarbon determinations measured at the Oxford Radiocarbon Accelerator Unit (ORAU). Amongst some of the sites included here are the latest series of determinations from the key sites of Abydos, El Mirón, Ban Chiang, Grotte de Pigeons (Taforalt), Alepotrypa and Oberkassel, as well as others dating to the Palaeolithic, Mesolithic and later periods. Comments on the significance of the results are provided by the submitters of the material

Tau Aggregation Inhibitor Therapy : An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

ACKNOWLEDGMENTS We thank patients and their caregivers for their participation in the study and are indebted to all the investigators involved in the study, particularly Drs. Douglas Fowlie and Donald Mowat for their helpful contributions to the clinical execution of the study in Scotland. We thank Sharon Eastwood, Parexel, for assistance in preparing initial drafts of the manuscript. We acknowledge constructive comments provided by Professors G. Wilcock and S. Gauthier on drafts of the article. CMW, CRH, and JMDS are officers of, and hold beneficial interests in, TauRx Therapeutics. RTS, PB, KK, and DJW are paid consultants to TauRx Therapeutics. The study was financed entirely by TauRx TherapeuticsPeer reviewedPublisher PD

Angiotensin II type 1 receptor antibodies in childhood kidney transplantation

Angiotensin II type 1 receptor antibodies (AT1 RAb) have emerged as non-HLA Ab present in patients with acute AMR and risk of graft loss. Furthermore, AT1 RAb have been shown to increase angiotensin II sensitivity which may play a role in the development of CVD and hypertension. Data on AT1 RAb in stable transplant recipients are lacking. The aim of this study was to analyze the levels of AT1 RAb in a cohort of stable patients after kidney transplantation (tx) in childhood. A cross-sectional study of 30 children (median age 14, range 3-19 yr, median time since tx five yr) and 28 adults who were transplanted in childhood (median age 26, range 20-40 yr, median time since tx 18 yr) transplanted between 1993-2006 and 1983-2002, respectively, was performed. Healthy controls were 51 healthy children (5-8 yr) and 199 healthy donors (median age 56.5 yr, range 42-83 yr). Plasma AT1 RAb were analyzed by immunoassay. Median total AT1 RAb IgG concentration was significantly higher in the pediatric-tx group as compared to the adult-tx group (40.0 and 10.95 U/mL, p < 0.0001). For both groups, the tx group showed higher levels: the pediatric-tx group vs. control group (40.0 vs. 13.3 U/mL, p = 0.0006) and the adult-tx group vs. adult control group (10.95 vs. 6.5 U/mL, p < 0.0001). Age was the strongest indicator of high levels of AT1 RAb IgG (p = 0.0003). AT1 RAb total IgG levels are significantly higher in a stable pediatric-tx cohort as compared to adult-tx patients and healthy controls of comparable age groups. The relevance of our findings in relation to age, time since tx, previous or future rejection, and CVD risk merits future studies

Successfully dating rock art in Southern Africa using improved sampling methods and new characterization and pretreatment protocols

©2016 University of Arizona. This is the Author Accepted Manuscript. Please refer to any applicable publisher terms of use.Worldwide, dating rock art is difficult to achieve because of the frequent lack of datable material and the difficulty of removing contamination from samples. Our research aimed to select the paints that would be the most likely to be successfully radiocarbon dated and to estimate the quantity of paint needed depending on the nature of the paint and the weathering and alteration products associated with it. To achieve this aim, a two-step sampling strategy, coupled with a multi-instrument characterization (including SEM-EDS, Raman spectroscopy, and FTIR spectroscopy analysis) and a modified acid-base-acid (ABA) pretreatment, was created. In total, 41 samples were dated from 14 sites in three separate regions of southern Africa. These novel protocols ensure that the 14C chronology produced was robust and could also be subsequently applied to different regions with possible variations in paint preparation, geology, weathering conditions, and contaminants

Physical restraint in residential child care : the experiences of young people and residential workers

There have long been concerns about the use of physical restraint in residential care. This paper presents the findings of a qualitative study which explores the experiences of children, young people and residential workers about physical restraint. The research identifies the dilemmas and ambiguities for both staff and young people, and participants discuss the situations where they feel physical restraint is appropriate as well as their concerns about unjustified or painful restraints. They describe the negative emotions involved in restraint but also those situations where, through positive relationships and trust, restraint can help young people through unsafe situations

Fermions scattering in a three dimensional extreme black hole background

The absorption cross section for scattering of fermions off an extreme BTZ black hole is calculated. It is shown that, as in the case of scalar particles, an extreme BTZ black hole exhibits a vanishing absorption cross section, which is consistent with the vanishing entropy of such object. Additionally, we give a general argument to prove that the particle flux near the horizon is zero. Finally we show that the {\it reciprocal space} introduced previously in \cite{gm} gives rise to the same result and, therefore, it could be considered as the space where the scattering process takes place in an AdS spacetime.Comment: 15 pages, RevTex4. Revised version. To be published in Class. Quantum. Gra

Integrating timescales with time-transfer functions: A practical approach for an INTIMATE database

© 2014 Elsevier Ltd.The purpose of the INTIMATE project is to integrate palaeo-climate information from terrestrial, ice and marine records so that the timing of environmental response to climate forcing can be compared in both space and time. One of the key difficulties in doing this is the range of different methods of dating that can be used across different disciplines. For this reason, one of the main outputs of INTIMATE has been to use an event-stratigraphic approach which enables researchers to co-register synchronous events (such as the deposition of tephra from major volcanic eruptions) in different archives (Blockley etal., 2012). However, this only partly solves the problem, because it gives information only at particular short intervals where such information is present. Between these points the ability to compare different records is necessarily less precise chronologically. What is needed therefore is a way to quantify the uncertainties in the correlations between different records, even if they are dated by different methods, and make maximum use of the information available that links different records. This paper outlines the design of a database that is intended to provide integration of timescales and associated environmental proxy information. The database allows for the fact that all timescales have their own limitations, which should be quantified in terms of the uncertainties quoted. It also makes use of the fact that each timescale has strengths in terms of describing the data directly associated with it. For this reason the approach taken allows users to look at data on any timescale that can in some way be related to the data of interest, rather than specifying a specific timescale or timescales which should always be used. The information going into the database is primarily: proxy information (principally from sediments and ice cores) against depth, age depth models against reference chronologies (typically IntCal or ice core), and time-transfer functions that relate different timescales to each other, through the use of event stratigraphies or global phenomena such as cosmogenic isotope production rate variations

Quark nova imprint in the extreme supernova explosion SN 2006gy

The extremely luminous supernova 2006gy (SN 2006gy) is among the most energetic ever observed. The peak brightness was 100 times that of a typical supernova and it spent an unheard of 250 days at magnitude -19 or brighter. Efforts to describe SN 2006gy have pushed the boundaries of current supernova theory. In this work we aspire to simultaneously reproduce the photometric and spectroscopic observations of SN 2006gy using a quark nova model. This analysis considers the supernova explosion of a massive star followed days later by the quark nova detonation of a neutron star. We lay out a detailed model of the interaction between the supernova envelope and the quark nova ejecta paying special attention to a mixing region which forms at the inner edge of the supernova envelope. This model is then fit to photometric and spectroscopic observations of SN 2006gy. This QN model naturally describes several features of SN 2006gy including the late stage light curve plateau, the broad H{\alpha} line and the peculiar blue H{\alpha} absorption. We find that a progenitor mass between 20Msun and 40Msun provides ample energy to power SN 2006gy in the context of a QN.Comment: 15 pages, 9 figure

Three-Dimensional Simulations of Magnetized Superbubbles: New Insights into the Importance of MHD Effects on Observed Quantities

We present three-dimensional magnetohydrodynamic (MHD) simulations of superbubbles, to study the importance of MHD effects in the interpretation of images from recent surveys of the Galactic plane. These simulations focus mainly on atmospheres defined by an exponential density distribution and the Dickey & Lockman (1990) density distribution. In each case, the magnetic field is parallel to the Galactic plane and we investigate cases with either infinite scale height (constant magnetic field) or a constant ratio of gas pressure to magnetic pressure. The three-dimensional structure of superbubbles in these simulations is discussed with emphasis on the axial ratio of the cavity as a function of magnetic field strength and the age of the bubble. We investigate systematic errors in the age of the bubble and scale height of the surrounding medium that may be introduced by modeling the data with purely hydrodynamic models. Age estimates derived with symmetric hydrodynamic models fitted to an asymmetric magnetized superbubble can differ by up to a factor of four, depending on the direction of the line of sight. The scale height of the surrounding medium based on the Kompaneets model may be up to 50% lower than the actual scale height. We also present the first ever predictions of Faraday rotation by a magnetized superbubble based on three-dimensional MHD simulations. We emphasize the importance of MHD effects in the interpretation of observations of superbubbles.Comment: 21 journal pages. 17 figures. 5 tables (added extensive discussion on the effect of cooling on the bubbles); Accepted for publications in the Astrophysical Journal. Related animations can be accessed via http://www.capca.ucalgary.c

How grazing management can maximize erosion resistance of salt marshes

Combining natural saltmarsh habitats with conventional barriers can provide a sustainable and cost-effective alternative for fully engineered flood protection, provided that a minimal salt marsh width can be guaranteed for a long period. Hence, it is essential to understand both the key factors and management options driving the lateral erodibility/stability of salt marshes.We aimed to determine how salt marsh management (i.e. grazing by large vs. small grazers vs. artificial mowing), marsh elevation and marsh age affect soil stability (i.e. soil collapse) and intrinsic lateral erodibility of salt marshes (i.e. particle-by-particle detachment). Soil cores were collected in high and low marshes (above and below 0.5 m MHWL, respectively) of different ages. At these locations, we compared cores from grazed areas to cores inside grazer exclosures, with and without artificial mowing. All cores were exposed to waves in flumes to test their stability and lateral erodibility.All soil cores were characterized by a stable fine-grained layer deposited on top of readily erodible sand. The thickness of the fine-grained layer was a key parameter in reducing salt marsh instability (cliff collapse). This layer thickness increased with marsh age and at lower elevations, but decreased with cattle grazing due to compaction.The erosion resistance of the fine-grained layer increased with (a) large grazers that compacted the soil by trampling, (b) mowing that excluded soil-bioturbating species, and (c) grazing by small grazers that promoted vegetation types with higher root density.Synthesis and applications. Overall, marshes with thinner cohesive and/or fine-grained top layers are more sensitive to lateral erosion than marshes with deep cohesive soils, independently of the management. Grazing and artificial mowing can reduce the erodibility of fine-grained soils, making salt marshes more resilient to lateral erosion. However, compaction by large grazers simultaneously leads to thinner fine-grained layers and lower elevation, potentially leading to more inundation under sea-level rise. Hence, to effectively manage salt marshes to enhance their contribution to coastal protection, we recommend (a) moderate/rotational livestock grazing, avoiding high intensity grazing in sediment-poor systems sensitive to sea-level rise and (b) investigating measures to preserve small grazers.</p